Macrophage MerTK promotes profibrogenic cross-talk with hepatic stellate cells via soluble mediators

[1]  D. Siemann,et al.  Gas6/Axl Signaling Pathway in the Tumor Immune Microenvironment , 2020, Cancers.

[2]  Jing Liu,et al.  Crosstalk Between Liver Macrophages and Surrounding Cells in Nonalcoholic Steatohepatitis , 2020, Frontiers in Immunology.

[3]  R. Schwabe,et al.  Macrophage MerTK Promotes Liver Fibrosis in Nonalcoholic Steatohepatitis. , 2019, Cell metabolism.

[4]  J. Lorens,et al.  A Functional Role of GAS6/TAM in Nonalcoholic Steatohepatitis Progression Implicates AXL as Therapeutic Target , 2019, Cellular and molecular gastroenterology and hepatology.

[5]  C. Rigamonti,et al.  Gas6/TAM Signaling Components as Novel Biomarkers of Liver Fibrosis , 2019, Disease markers.

[6]  C. Ponting,et al.  Resolving the fibrotic niche of human liver cirrhosis at single cell level , 2019, Nature.

[7]  F. Marra,et al.  Role of Myeloid-Epithelial-Reproductive Tyrosine Kinase and Macrophage Polarization in the Progression of Atherosclerotic Lesions Associated With Nonalcoholic Fatty Liver Disease , 2019, Front. Pharmacol..

[8]  F. Tacke,et al.  Liver Macrophages: Old Dogmas and New Insights , 2019, Hepatology communications.

[9]  S. Resino,et al.  The Myeloid-Epithelial-Reproductive Tyrosine Kinase (MERTK) rs4374383 Polymorphism Predicts Progression of Liver Fibrosis in Hepatitis C Virus-Infected Patients: A Longitudinal Study , 2018, Journal of clinical medicine.

[10]  R. Birge,et al.  MerTK signaling in macrophages promotes the synthesis of inflammation resolution mediators by suppressing CaMKII activity , 2018, Science Signaling.

[11]  Xunrong Luo,et al.  Receptor tyrosine kinase MerTK suppresses an allogenic type I IFN response to promote transplant tolerance , 2018, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[12]  N. Inui,et al.  Macrophage mannose receptor, CD206, predict prognosis in patients with pulmonary tuberculosis , 2018, Scientific Reports.

[13]  P. Cohen,et al.  Antibody Cross-Linking of CD14 Activates MerTK and Promotes Human Macrophage Clearance of Apoptotic Neutrophils: the Dual Role of CD14 at the Crossroads Between M1 and M2c Polarization , 2018, Inflammation.

[14]  B. Hinz,et al.  The big five in fibrosis: Macrophages, myofibroblasts, matrix, mechanics, and miscommunication. , 2018, Matrix biology : journal of the International Society for Matrix Biology.

[15]  A. Feldstein,et al.  Triggering and resolution of inflammation in NASH , 2018, Nature Reviews Gastroenterology & Hepatology.

[16]  Meritxell Huch,et al.  The balancing act of the liver: tissue regeneration versus fibrosis , 2018, The Journal of clinical investigation.

[17]  S. Friedman,et al.  Mechanisms of hepatic stellate cell activation , 2017, Nature Reviews Gastroenterology &Hepatology.

[18]  M. Safran,et al.  Both MAPK and STAT3 signal transduction pathways are necessary for IL-6-dependent hepatic stellate cells activation , 2017, PloS one.

[19]  C. Weston,et al.  MerTK expressing hepatic macrophages promote the resolution of inflammation in acute liver failure , 2017, Gut.

[20]  K. Kodys,et al.  Hepatocellular carcinoma is accelerated by NASH involving M2 macrophage polarization mediated by hif-1αinduced IL-10 , 2016, Oncoimmunology.

[21]  Gordana Vunjak-Novakovic,et al.  Differential gene expression in human, murine, and cell line-derived macrophages upon polarization. , 2016, Experimental cell research.

[22]  O. Wallerman,et al.  Genetic prevention of hepatitis C virus‐induced liver fibrosis by allele‐specific downregulation of MERTK , 2016, Hepatology research : the official journal of the Japan Society of Hepatology.

[23]  Hee-Sun Kim,et al.  Liver X receptor and STAT1 cooperate downstream of Gas6/Mer to induce anti-inflammatory arginase 2 expression in macrophages , 2016, Scientific Reports.

[24]  T. Wynn,et al.  Macrophages in Tissue Repair, Regeneration, and Fibrosis. , 2016, Immunity.

[25]  C. Tripodo,et al.  MERTK rs4374383 polymorphism affects the severity of fibrosis in non-alcoholic fatty liver disease. , 2016, Journal of hepatology.

[26]  B. Fleischmann,et al.  Myeloid-Epithelial-Reproductive Receptor Tyrosine Kinase and Milk Fat Globule Epidermal Growth Factor 8 Coordinately Improve Remodeling After Myocardial Infarction via Local Delivery of Vascular Endothelial Growth Factor , 2016, Circulation.

[27]  N. Câmara,et al.  Macrophages During the Fibrotic Process: M2 as Friend and Foe , 2015, Front. Immunol..

[28]  Min Zhang,et al.  Activated hepatic stellate cells promote angiogenesis via interleukin-8 in hepatocellular carcinoma , 2015, Journal of Translational Medicine.

[29]  M. Marí,et al.  Gas6/Axl pathway is activated in chronic liver disease and its targeting reduces fibrosis via hepatic stellate cell inactivation. , 2015, Journal of hepatology.

[30]  G. Auzinger,et al.  University of Birmingham Patients With Acute-on-Chronic Liver Failure Have Increased Numbers of Regulatory Immune Cells Expressing the Receptor Tyrosine Kinase MERTK , 2014 .

[31]  Z. Halpern,et al.  Infiltrating Monocyte-Derived Macrophages and Resident Kupffer Cells Display Different Ontogeny and Functions in Acute Liver Injury , 2014, The Journal of Immunology.

[32]  Alberto Mantovani,et al.  Macrophage plasticity and polarization in liver homeostasis and pathology , 2014, Hepatology.

[33]  Frank Tacke,et al.  Macrophage heterogeneity in liver injury and fibrosis. , 2014, Journal of hepatology.

[34]  R. Schwabe,et al.  Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice , 2013, Hepatology.

[35]  S. Frye,et al.  UNC569, a Novel Small-Molecule Mer Inhibitor with Efficacy against Acute Lymphoblastic Leukemia In Vitro and In Vivo , 2013, Molecular Cancer Therapeutics.

[36]  H. Earp,et al.  Molecular Pathways Molecular Pathways : MERTK Signaling in Cancer , 2013 .

[37]  M. Furue,et al.  Interferon-γ enhances phorbol myristate acetate-induced cell attachment and tumor necrosis factor production via the NF-κB pathway in THP-1 human monocytic cells. , 2013, Molecular medicine reports.

[38]  Z. Kutalik,et al.  Genome-wide association study identifies variants associated with progression of liver fibrosis from HCV infection. , 2012, Gastroenterology.

[39]  M. Monestier,et al.  Efficient Clearance of Early Apoptotic Cells by Human Macrophages Requires M2c Polarization and MerTK Induction , 2012, The Journal of Immunology.

[40]  P. Tak,et al.  Systematic validation of specific phenotypic markers for in vitro polarized human macrophages. , 2012, Journal of immunological methods.

[41]  L. Castello,et al.  TNF‐α, IL‐6, and IL‐1 expression is inhibited by GAS6 in monocytes/macrophages , 2010, Journal of leukocyte biology.

[42]  Brandoch D. Cook,et al.  Transforming growth factor‐beta 1 (TGF‐β1) induces angiogenesis through vascular endothelial growth factor (VEGF)‐mediated apoptosis , 2009, Journal of cellular physiology.

[43]  P. Lin,et al.  Human protein S inhibits the uptake of AcLDL and expression of SR-A through Mer receptor tyrosine kinase in human macrophages. , 2009, Blood.

[44]  A. Barral,et al.  A simple method for human peripheral blood monocyte isolation. , 2000, Memorias do Instituto Oswaldo Cruz.

[45]  S. Milani,et al.  Regulation of extracellular matrix synthesis by transforming growth factor beta 1 in human fat-storing cells. , 1993, Gastroenterology.

[46]  S. Friedman,et al.  Activation of cultured rat hepatic lipocytes by Kupffer cell conditioned medium. Direct enhancement of matrix synthesis and stimulation of cell proliferation via induction of platelet-derived growth factor receptors. , 1989, The Journal of clinical investigation.

[47]  H. Earp,et al.  TAM receptor tyrosine kinases: biologic functions, signaling, and potential therapeutic targeting in human cancer. , 2008, Advances in cancer research.