USE OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS ON PERIODONTAL THERAPY IN PATIENTS WITH COMORBID PATHOLOGY

Subject. This paper covers the main aspects of non-steroidal anti-inflammatory drugs (NSAIDs) used on periodontal therapy in patients with cormobid pathology. Objectives. A domestic and foreign literature review on effects of NSAIDs on periodontal therapy in patients with cormobid pathology. Methodology. The literature review is based on the source literature available over the past five years starting 2015 by PubMed keywords in order to summarize the subject information. Conclusion. NSAIDs, therefore, remain the most essential medications on etiotropic, pathogenetic and symptomatic therapy of dental disorders. NSAIDs can help manage pain syndrome, control inflammation responses and regeneration with indulating inflammation-induced tissue destruction, prevent unnecessary complications during basic and supportive periodontal therapy including invasive techniques. Systemic and localized use of NSAIDs in the complex periodontal therapy based on the rational choice of the drug and the appropriate dose selection considering patient’s comorbidities must be necessarily supported by the dentist’s knowledge of pharmacodynamics and NSAIDs classifications with Clinical Guidance on rational use of NSAIDs (2015, revised 2018) and Clinical Guidance on comorbid pathology (2019) taken as the basis. These, therefore, will ensure the personified approach, efficacy and safety of NSAID use in patients.