Nodal positivity decreases with age in women with early‐stage, hormone receptor–positive breast cancer

Despite data demonstrating the safety of omitting axillary surgery in older women with early‐stage breast cancer, the incidence of axillary surgery remains high. It was hypothesized that the prevalence of nodal positivity would decrease with advancing age.

[1]  M. Blettner,et al.  Does chemotherapy improve survival in patients with nodal positive luminal A breast cancer? A retrospective Multicenter Study , 2019, PloS one.

[2]  Tyler C Wind,et al.  Radiation Therapy After Breast-Conserving Surgery in Women 70 Years of Age and Older: How Wisely Do We Choose? , 2019, Annals of Surgical Oncology.

[3]  O. Olopade,et al.  Community clinical practice patterns and mortality in patients with intermediate oncotype DX recurrence scores: Who benefits from chemotherapy? , 2018, Cancer.

[4]  G. Nieuwenhuijzen,et al.  The rationale for and long-term outcome of incomplete axillary staging in elderly women with primary breast cancer. , 2018, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.

[5]  T. Hyslop,et al.  Axillary Nodal Evaluation in Elderly Breast Cancer Patients: Potential Effects on Treatment Decisions and Survival , 2018, Annals of Surgical Oncology.

[6]  M. Morrow,et al.  Lymph Node Status in Breast Cancer Does Not Predict Tumor Biology , 2018, Annals of Surgical Oncology.

[7]  Virginia G Kaklamani,et al.  Adjuvant Chemotherapy Guided by a 21‐Gene Expression Assay in Breast Cancer , 2018, The New England journal of medicine.

[8]  M. Goetz,et al.  Predicting Nodal Positivity in Women 70 Years of Age and Older with Hormone Receptor-Positive Breast Cancer to Aid Incorporation of a Society of Surgical Oncology Choosing Wisely Guideline into Clinical Practice , 2017, Annals of Surgical Oncology.

[9]  L. Wilson,et al.  Association of LN Evaluation with Survival in Women Aged 70 Years or Older With Clinically Node-Negative Hormone Receptor Positive Breast Cancer , 2017, Annals of Surgical Oncology.

[10]  G. Danaei,et al.  Development and Validation of a 10-Year Mortality Prediction Model: Meta-Analysis of Individual Participant Data From Five Cohorts of Older Adults in Developed and Developing Countries , 2017, The journals of gerontology. Series A, Biological sciences and medical sciences.

[11]  M. Goetz,et al.  Has the Time Come to Stop Surgical Staging of the Axilla for All Women Age 70 Years or Older with Hormone Receptor-Positive Breast Cancer? , 2017, Annals of Surgical Oncology.

[12]  L. V. van't Veer,et al.  70-Gene Signature as an Aid to Treatment Decisions in Early-Stage Breast Cancer. , 2016, The New England journal of medicine.

[13]  N. Howlader,et al.  Breast-cancer-specific mortality in patients treated based on the 21-gene assay: a SEER population-based study , 2016, npj Breast Cancer.

[14]  E. Mardis,et al.  Development and verification of the PAM50-based Prosigna breast cancer gene signature assay , 2015, BMC Medical Genomics.

[15]  A. Giuliano,et al.  Not Performing a Sentinel Node Biopsy for Older Patients With Early-Stage Invasive Breast Cancer. , 2015, JAMA surgery.

[16]  W. Wood,et al.  Geriatric assessment-identified deficits in older cancer patients with normal performance status. , 2015, The oncologist.

[17]  R. Jagsi,et al.  Radiation field design in the ACOSOG Z0011 (Alliance) Trial. , 2014, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[18]  Barbara L. Smith,et al.  Lumpectomy plus tamoxifen with or without irradiation in women age 70 years or older with early breast cancer: long-term follow-up of CALGB 9343. , 2013, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[19]  A. Giuliano,et al.  Axillary dissection vs no axillary dissection in women with invasive breast cancer and sentinel node metastasis: a randomized clinical trial. , 2011, JAMA.

[20]  M. Daidone,et al.  Axillary Dissection Versus No Axillary Dissection in Elderly Patients with Breast Cancer and No Palpable Axillary Nodes: Results After 15 Years of Follow-Up , 2010, Annals of Surgical Oncology.

[21]  B. van Calster,et al.  Relationship between age and axillary lymph node involvement in women with breast cancer. , 2009, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[22]  J. Hentz,et al.  Older Age Independently Predicts a Lower Risk of Sentinel Lymph Node Metastasis in Breast Cancer , 2005, Annals of Surgical Oncology.

[23]  Donna Spiegelman,et al.  Easy SAS calculations for risk or prevalence ratios and differences. , 2005, American journal of epidemiology.

[24]  H. Cohen,et al.  Adjuvant chemotherapy in older and younger women with lymph node-positive breast cancer. , 2005, JAMA.

[25]  Barbara L. Smith,et al.  Lumpectomy plus tamoxifen with or without irradiation in women 70 years of age or older with early breast cancer. , 2004, The New England journal of medicine.

[26]  J. Forbes,et al.  A randomized trial comparing axillary clearance versus no axillary clearance in older patients (≥ 60 years) with breast cancer: First results of International Breast Cancer Study Group Trial 10-93. , 2004, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[27]  Jong-Hyeon Jeong,et al.  Twenty-five-year follow-up of a randomized trial comparing radical mastectomy, total mastectomy, and total mastectomy followed by irradiation. , 2002, The New England journal of medicine.

[28]  M. Morrow.  Randomized Trial Comparing Axillary Clearance Versus No Axillary Clearance in Older Patients With Breast Cancer: First Results of International Breast Cancer Study Group Trial 10–93 , 2007 .