Stimulation of the atypical chemokine receptor 3 (ACKR3) by a small-molecule agonist attenuates fibrosis in a preclinical liver but not lung injury model

[1]  W. V. van IJcken,et al.  Endothelial Zeb2 preserves the hepatic angioarchitecture and protects against liver fibrosis , 2021, Cardiovascular research.

[2]  D. Dyer Understanding the mechanisms that facilitate specificity, not redundancy, of chemokine‐mediated leukocyte recruitment , 2020, Immunology.

[3]  C. Ponting,et al.  Resolving the fibrotic niche of human liver cirrhosis at single cell level , 2019, Nature.

[4]  I. Amit,et al.  Paired-cell sequencing enables spatial gene expression mapping of liver endothelial cells , 2018, Nature Biotechnology.

[5]  Loyal A Goff,et al.  Transcriptional and epigenomic landscapes of CNS and non-CNS vascular endothelial cells , 2018, eLife.

[6]  R. Nibbs,et al.  A guide to chemokines and their receptors , 2018, The FEBS journal.

[7]  David A. Price,et al.  Discovery of a Novel Small-Molecule Modulator of C-X-C Chemokine Receptor Type 7 as a Treatment for Cardiac Fibrosis. , 2018, Journal of medicinal chemistry.

[8]  G. Schoofs,et al.  A Flow Cytometry-based Assay to Identify Compounds That Disrupt Binding of Fluorescently-labeled CXC Chemokine Ligand 12 to CXC Chemokine Receptor 4. , 2018, Journal of visualized experiments : JoVE.

[9]  T. Van Loy,et al.  A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators. , 2018, Journal of visualized experiments : JoVE.

[10]  J. Wess,et al.  Lack of beta-arrestin signaling in the absence of active G proteins , 2018, Nature Communications.

[11]  M. Pauta,et al.  A small population of liver endothelial cells undergoes endothelial-to-mesenchymal transition in response to chronic liver injury. , 2017, American journal of physiology. Gastrointestinal and liver physiology.

[12]  Jun Zhou,et al.  CXCR7 attenuates the TGF-β-induced endothelial-to-mesenchymal transition and pulmonary fibrosis. , 2017, Molecular bioSystems.

[13]  W. Luyten,et al.  Signaling properties of the human chemokine receptors CXCR4 and CXCR7 by cellular electric impedance measurements , 2017, PloS one.

[14]  Jialin C. Zheng,et al.  CXCL12 enhances angiogenesis through CXCR7 activation in human umbilical vein endothelial cells , 2017, Scientific Reports.

[15]  T. Van Loy,et al.  Comparison of cell-based assays for the identification and evaluation of competitive CXCR4 inhibitors , 2017, PloS one.

[16]  B. Ding,et al.  Loss of Endothelial CXCR7 Impairs Vascular Homeostasis and Cardiac Remodeling After Myocardial Infarction: Implications for Cardiovascular Drug Discovery , 2017, Circulation.

[17]  E. Borroni,et al.  Overview and potential unifying themes of the atypical chemokine receptor family , 2016, Journal of leukocyte biology.

[18]  F. Mendoza,et al.  Endothelial to Mesenchymal Transition (EndoMT) in the Pathogenesis of Human Fibrotic Diseases , 2016, Journal of clinical medicine.

[19]  S. Rafii,et al.  Targeting of the pulmonary capillary vascular niche promotes lung alveolar repair and ameliorates fibrosis , 2016, Nature Medicine.

[20]  H. Okamoto,et al.  The Angiocrine Factor Rspondin3 Is a Key Determinant of Liver Zonation. , 2015, Cell reports.

[21]  Bumseok Kim,et al.  Differential Roles of Angiogenesis in the Induction of Fibrogenesis and the Resolution of Fibrosis in Liver. , 2015, Biological & pharmaceutical bulletin.

[22]  R. Nusse,et al.  Self-renewing diploid Axin2+ cells fuel homeostatic renewal of the liver , 2015, Nature.

[23]  Feng Zhang,et al.  Update on implications and mechanisms of angiogenesis in liver fibrosis , 2015, Hepatology research : the official journal of the Japan Society of Hepatology.

[24]  A. Luster,et al.  Chemokines and chemokine receptors: positioning cells for host defense and immunity. , 2014, Annual review of immunology.

[25]  A. Mantovani,et al.  New nomenclature for atypical chemokine receptors , 2014, Nature Immunology.

[26]  Michael Simons,et al.  Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis , 2013, Nature.

[27]  R. Nibbs,et al.  Immune regulation by atypical chemokine receptors , 2013, Nature Reviews Immunology.

[28]  R. Kraft,et al.  The presumed atypical chemokine receptor CXCR7 signals through Gi/o proteins in primary rodent astrocytes and human glioma cells , 2012, Glia.

[29]  R. A. Mir,et al.  CXCR7 mediated Giα independent activation of ERK and Akt promotes cell survival and chemotaxis in T cells. , 2012, Cellular immunology.

[30]  J. Pfeilschifter,et al.  CXCL10 promotes liver fibrosis by prevention of NK cell mediated hepatic stellate cell inactivation. , 2010, Journal of autoimmunity.

[31]  B. Barres,et al.  The Mouse Blood-Brain Barrier Transcriptome: A New Resource for Understanding the Development and Function of Brain Endothelial Cells , 2010, PloS one.

[32]  J. Engele,et al.  CXCR7 is an active component of SDF-1 signalling in astrocytes and Schwann cells , 2010, Journal of Cell Science.

[33]  B. Adams Faculty Opinions recommendation of Beta-arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7. , 2010 .

[34]  R. Lefkowitz,et al.  β-arrestin- but not G protein-mediated signaling by the “decoy” receptor CXCR7 , 2009, Proceedings of the National Academy of Sciences.

[35]  F. Baleux,et al.  CXCR7 heterodimerizes with CXCR4 and regulates CXCL12-mediated G protein signaling. , 2009, Blood.

[36]  C. Chuaqui,et al.  SM16, an Orally Active TGF-&bgr; Type I Receptor Inhibitor Prevents Myofibroblast Induction and Vascular Fibrosis in the Rat Carotid Injury Model , 2008, Arteriosclerosis, thrombosis, and vascular biology.

[37]  H. Bolte,et al.  Standardized quantification of pulmonary fibrosis in histological samples. , 2008, BioTechniques.

[38]  Kevin Wei,et al.  A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development , 2006, The Journal of experimental medicine.

[39]  M. Thelen,et al.  The Chemokine SDF-1/CXCL12 Binds to and Signals through the Orphan Receptor RDC1 in T Lymphocytes* , 2005, Journal of Biological Chemistry.

[40]  M. Matsuoka,et al.  Development of specific CXCR4 inhibitors possessing high selectivity indexes as well as complete stability in serum based on an anti-HIV peptide T140. , 2001, Bioorganic & medicinal chemistry letters.