Asymmetric Synthesis of ChiralOxazolines by Organocatalytic Cyclization of α-Aryl Isocyanoesterswith Aldehydes
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A cinchona alkaloid derivative catalyzed the asymmetric formal [3+2] cycloaddition of α-aryl isocyanoesters with aldehydes, affording highly substituted 2-oxazolines with good stereoselectivities of up to 18:1 dr and 90% ee.