The pressor effect of the antidiuretic principle of the posterior pituitary in orthostatic hypotension.

Although the antidiuretic property of posterior pituitary extracts is well established, investigators have repeatedly failed to demonstrate a pressor effect of these substances in man (1, 2). Consequently, the hemodynamic effects of posterior pituitary hormones have received relatively little attention. However, it is known that posterior pituitary extracts do produce an increase in arterial pressure after injection into anesthetized or spinal animals (3, 4). The purpose of this report is to present observations on a disease state in man in which it was found that posterior pituitary hormones have a marked effect on arterial pressure.

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