论文信息 - New views into the prostate cancer genome.

New views into the prostate cancer genome.

Genomic analysis of prostate cancer has not answered key clinical questions such as "Which tumors are likely to recur?" or "Which pathways should we target for treatment?" The study by Taylor et al., initiated by the late William Gerald, published in this issue of Cancer Cell is a game changer.

S. Powers | L. Trotman | Scott Powers | Lloyd Trotman

[1] Yudong D. He,et al. A Gene-Expression Signature as a Predictor of Survival in Breast Cancer , 2002 .

[2] M. Cronin,et al. A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer. , 2004, The New England journal of medicine.

[3] Pier Paolo Pandolfi,et al. Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate , 2009, Nature Genetics.

[4] C. Sander,et al. Integrative genomic profiling of human prostate cancer. , 2010, Cancer cell.

[5] C. Sander,et al. Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis , 2009, Nature Genetics.

[6] J. Mesirov,et al. Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. , 1999, Science.

[7] Christian A. Rees,et al. Distinctive gene expression patterns in human mammary epithelial cells and breast cancers. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[8] P. Scardino,et al. Critical review of prostate cancer predictive tools. , 2009, Future oncology.

[9] Kenny Q. Ye,et al. Novel patterns of genome rearrangement and their association with survival in breast cancer. , 2006, Genome research.