RESPONSE OF RAT LUNG TO HUMORAL MEDIATORS OF ANAPHYLAXIS AND ITS MODIFICATION BY DRUGS AND SENSITIZATION

1 The effects of humoral mediators of anaphylaxis on the bronchial function of the pithed rat have been assessed and compared with their effects in the guinea‐pig and man. 2 5‐Hydroxtryptamine, acetylcholine and bradykinin were bronchoconstrictor. Slow reacting substance in anaphylaxis and prostaglandin F2α caused only slight constriction at high doses and histamine was not active. 3 Bradykinin was less active in the rat than in the guinea‐pig and its effects were not antagonized by anti‐inflammatory analgesic drugs. 4 β‐Adrenoceptor blockade potentiated the activity of bradykinin but not that of 5‐hydroxytryptamine or acetylcholine. 5 Dexamethasone reduced the activity of bradykinin but not that of 5‐hydroxytryptamine or acetylcholine. 6 Sensitization with Nippostrongylus brasiliensis did not increase the sensitivity of the rat lung to the effects of mediators.

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