Neurologic and neuroimagingfindings in patients with COVID-19 A retrospective multicenter study

Objective To describe neuroimaging findings and to report the epidemiologic and clinical characteristics of patients with coronavirus disease 2019 (COVID-19) with neurologic manifestations. Methods In this retrospective multicenter study (11 hospitals), we included 64 patients with confirmed COVID-19 with neurologic manifestations who underwent a brain MRI. Results The cohort included 43 men (67%) and 21 women (33%); their median age was 66 (range 20–92) years. Thirty-six (56%) brain MRIs were considered abnormal, possibly related to severe acute respiratory syndrome coronavirus. Ischemic strokes (27%), leptomeningeal MORE ONLINE COVID-19 Resources For the latest articles, invited commentaries, and blogs from physicians around the world

[1]  D. Hess,et al.  COVID-19-Related Stroke , 2020, Translational Stroke Research.

[2]  Mickaël Ohana,et al.  High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study , 2020, Intensive Care Medicine.

[3]  S. Farmer,et al.  Characteristics of ischaemic stroke associated with COVID-19 , 2020, Journal of Neurology, Neurosurgery, and Psychiatry.

[4]  S. Kremer,et al.  Neurologic Features in Severe SARS-CoV-2 Infection , 2020, The New England journal of medicine.

[5]  L. Mao,et al.  Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China. , 2020, JAMA neurology.

[6]  N. Enomoto,et al.  A first case of meningitis/encephalitis associated with SARS-Coronavirus-2 , 2020, International Journal of Infectious Diseases.

[7]  Suresh Patel,et al.  COVID-19–associated Acute Hemorrhagic Necrotizing Encephalopathy: CT and MRI Features , 2020, Radiology.

[8]  Tao Guo,et al.  Cardiovascular Implications of Fatal Outcomes of Patients With Coronavirus Disease 2019 (COVID-19) , 2020, JAMA cardiology.

[9]  Ting Yu,et al.  Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study , 2020, The Lancet.

[10]  Y. Hu,et al.  Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China , 2020, The Lancet.

[11]  Alain Le Coupanec,et al.  Human Coronaviruses and Other Respiratory Viruses: Underestimated Opportunistic Pathogens of the Central Nervous System? , 2019, Viruses.

[12]  M. Toledano,et al.  Infectious encephalitis: mimics and chameleons , 2019, Practical Neurology.

[13]  G. Christodoulopoulos,et al.  Case Report of Transmissible Gastroenteritis Coronavirus Infection Associated with Small Intestine and Brain Lesions in Piglets. , 2019, Viral immunology.

[14]  Alexis M. Kalergis,et al.  Neurologic Alterations Due to Respiratory Virus Infections , 2018, Front. Cell. Neurosci..

[15]  J. Heo,et al.  Neurological Complications during Treatment of Middle East Respiratory Syndrome , 2017, Journal of clinical neurology.

[16]  Bryan R. Smith,et al.  Leptomeningeal gadolinium enhancement across the spectrum of chronic neuroinflammatory diseases , 2017, Neurology.

[17]  Yuji Numaguchi,et al.  Cytotoxic Lesions of the Corpus Callosum That Show Restricted Diffusion: Mechanisms, Causes, and Manifestations. , 2017, Radiographics : a review publication of the Radiological Society of North America, Inc.

[18]  X. Li,et al.  Coronavirus Infections in the Central Nervous System and Respiratory Tract Show Distinct Features in Hospitalized Children , 2017, Intervirology.

[19]  David K Meyerholz,et al.  Middle East Respiratory Syndrome Coronavirus Causes Multiple Organ Damage and Lethal Disease in Mice Transgenic for Human Dipeptidyl Peptidase 4 , 2015, The Journal of infectious diseases.

[20]  A. Hajeer,et al.  Severe neurologic syndrome associated with Middle East respiratory syndrome corona virus (MERS-CoV) , 2015, Infection.

[21]  Alain Le Coupanec,et al.  Human coronaviruses: Viral and cellular factors involved in neuroinvasiveness and neuropathogenesis , 2014, Virus Research.

[22]  Richard Beale,et al.  The Berlin definition of ARDS: an expanded rationale, justification, and supplementary material , 2012, Intensive Care Medicine.

[23]  R. Cohrs,et al.  Virus vasculopathy and stroke: an under-recognized cause and treatment target. , 2010, Infectious disorders drug targets.

[24]  R. Ransohoff,et al.  Localizing central nervous system immune surveillance: Meningeal antigen‐presenting cells activate T cells during experimental autoimmune encephalomyelitis , 2009, Annals of neurology.

[25]  S. Stuckey,et al.  Hyperintensity in the subarachnoid space on FLAIR MRI. , 2007, AJR. American journal of roentgenology.

[26]  P. Tan,et al.  Large artery ischaemic stroke in severe acute respiratory syndrome (SARS) , 2004, Journal of Neurology.

[27]  B. Murphy,et al.  Mechanisms of Host Defense following Severe Acute Respiratory Syndrome-Coronavirus (SARS-CoV) Pulmonary Infection of Mice , 2004, The Journal of Immunology.

[28]  K. Yuen,et al.  Possible Central Nervous System Infection by SARS Coronavirus , 2004, Emerging infectious diseases.

[29]  J. Sung,et al.  Detection of SARS Coronavirus RNA in the Cerebrospinal Fluid of a Patient with Severe Acute Respiratory Syndrome , 2003, Clinical chemistry.

[30]  J. Newcombe,et al.  Neuroinvasion by Human Respiratory Coronaviruses , 2000, Journal of Virology.

[31]  S. Subramaniam,et al.  Procoagulant activity during viral infections. , 2018, Frontiers in bioscience.

[32]  H. Faden,et al.  Detection of coronavirus in the central nervous system of a child with acute disseminated encephalomyelitis. , 2004, Pediatrics.