Exposure to priority organochlorine contaminants in the Italian general population. Part 2

Concentrations of 36 polychlorinated biphenyl (PCB) congeners were measured in serum of 372 Italian residents of general population living in Novafeltria, Pavia, and Milan. Total PCB level differed significantly between these sites (p < 0.0001) with median concentrations of 836.50, 1354.57, and 2062.08 pmol/g lipid, respectively. However, there is no evidence for the difference in distribution of total PCB levels by genders. Total dioxin-like PCBs differed significantly (p < 0.0001) between the sites (median 109.78, 50.88, and 166.99 pmol/g lipid, respectively) and genders of Novafeltria and Pavia (p = 0.011 and 0.009, respectively). PCB 138, 153, 170, and 180 differed significantly between the places of residence (p < 0.0001) with higher values in Milan population. In the overall population, total PCB and PCB 138, 153, 156, 170, and 180 correlated positively with age (correlations range between 0.320 and 0.569, p < 0.0001). In Novafeltria, the correlations ranged between 0.545 and 0.670, and in Pavia, the correlations ranged between 0.516 and 0.666. In Milan, correlations with age range between 0.327 and 0.417 for total PCB and congeners 138, 153, and 180. With an exception of PCB 170, there was no evidence of significant difference in the distribution of most abundant PCB congeners and total PCB across the body mass index categories.

[1]  S. Mandić-Rajčević,et al.  Exposure to priority organochlorine contaminants in the Italian general population. Part 1. Eight priority organochlorinated pesticides in blood serum , 2013, Human & experimental toxicology.

[2]  R. Tresserras,et al.  Distribution of blood concentrations of persistent organic pollutants in a representative sample of the population of Catalonia. , 2010, Environment international.

[3]  A. Mantovani,et al.  A simple and fast method for the determination of selected organohalogenated compounds in serum samples from the general population. , 2010, Toxicology letters.

[4]  P. Apostoli,et al.  Distribution of persistent organochlorine pollutants in maternal and foetal tissues: data from an Italian polluted urban area. , 2009, Chemosphere.

[5]  E. Abad,et al.  Serum levels of polychlorinated dibenzodioxins and dibenzofurans and PCBs in the general population living near an urban waste treatment plant in Biscay, Basque Country. , 2009, Chemosphere.

[6]  Paige L. Williams,et al.  Predictors of Serum Dioxins and PCBs among Peripubertal Russian Boys , 2009, Environmental health perspectives.

[7]  A. di Domenico,et al.  Endometriosis and Organochlorinated Environmental Pollutants: A Case–Control Study on Italian Women of Reproductive Age , 2009, Environmental health perspectives.

[8]  M. Magoni,et al.  Polychlorinated biphenyls and thyroid hormone serum concentrations among people living in a highly polluted area: a cross-sectional population-based study. , 2008, Environmental research.

[9]  C. La Rocca,et al.  PCDD/F and PCB in human serum of differently exposed population groups of an Italian city. , 2008, Chemosphere.

[10]  M. Černá,et al.  Serum concentrations of indicator PCB congeners in the Czech adult population. , 2008, Chemosphere.

[11]  A. di Domenico,et al.  Serum levels of PCDDs, PCDFs and PCBs in non-occupationally exposed population groups living near two incineration plants in Tuscany, Italy. , 2008, Chemosphere.

[12]  T. Vartiainen,et al.  Polychlorinated biphenyls (PCBs) and hydroxy-PCBs in adipose tissue of women in Southeast Spain. , 2008, Chemosphere.

[13]  Yoon-Seok Chang,et al.  Congener-specific approach to human PCB concentrations by serum analysis. , 2007, Chemosphere.

[14]  C. L. Wienburg,et al.  Factors influencing the national distribution of polycyclic aromatic hydrocarbons and polychlorinated biphenyls in British soils. , 2006, Environmental science & technology.

[15]  E. Negri,et al.  Overweight and obesity in Italian adults 2004, and an overview of trends since 1983 , 2006, European Journal of Clinical Nutrition.

[16]  C. Minoia,et al.  Assessment of dietary intake of polychlorinated biphenyls from a total diet study conducted in Pavia, Northern Italy , 2006, Food additives and contaminants.

[17]  H. Neels,et al.  Organohalogenated pollutants in human serum from Iassy, Romania and their relation with age and gender. , 2006, Environment international.

[18]  M. Magoni,et al.  Exposure to polychlorinated biphenyls in residents near a chemical factory in Italy: the food chain as main source of contamination. , 2006, Chemosphere.

[19]  N. Kajiwara,et al.  Human Blood Monitoring Program in Japan: Contamination and Bioaccumulation of Persistent Organochlorines in Japanese Residents , 2006, Archives of environmental contamination and toxicology.

[20]  A. di Domenico,et al.  Increased levels of polychlorobiphenyls in Italian women with endometriosis. , 2006, Chemosphere.

[21]  Kevin C Jones,et al.  Organohalogen chemicals in human blood from the United Kingdom. , 2006, Environmental pollution.

[22]  A. Marinaccio,et al.  Reference values of coplanar and non-coplanar PCBs in serum samples from two Italian population groups. , 2006, Toxicology letters.

[23]  M. Magoni,et al.  Assessment of reference values for polychlorinated biphenyl concentration in human blood. , 2005, Chemosphere.

[24]  Y. Yun,et al.  Distribution of organochlorines and PCB congeners in Korean human tissues , 2005, Archives of pharmacal research.

[25]  T. Nakano,et al.  Congener-specific analysis of polychlorinated biphenyl in human blood from Japanese , 2005, Environmental geochemistry and health.

[26]  A. di Domenico,et al.  Dioxin-like compounds and endometriosis: a study on Italian and Belgian women of reproductive age. , 2004, Toxicology letters.

[27]  M. Bates,et al.  Persistent organochlorines in the serum of the non-occupationally exposed New Zealand population. , 2004, Chemosphere.

[28]  R. Fanelli,et al.  Critical evaluation of a high-throughput analytical method for polychlorinated biphenyls in human serum: which detector for the establishment of the reference values? , 2004, Rapid Communications in Mass Spectrometry.

[29]  K. Schramm,et al.  Half-lives of tetra-, penta-, hexa-, hepta-, and octachlorodibenzo-p-dioxin in rats, monkeys, and humans--a critical review. , 2002, Chemosphere.

[30]  J. Pacyna,et al.  Towards a global historical emission inventory for selected PCB congeners--a mass balance approach. 1. Global production and consumption. , 2002, The Science of the total environment.

[31]  J. Freudenheim,et al.  Exposures associated with serum organochlorine levels among postmenopausal women from western New York State. , 2002, American journal of industrial medicine.

[32]  R. Fanelli,et al.  Level, sources and toxicity of polychlorinated biphenyls in the Italian diet. , 1999, Chemosphere.

[33]  L. Liberti,et al.  Accidental Road Spilling of Polychlorobiphenyls – A Case History , 1992 .

[34]  A. Domenico,et al.  A case study: A polychlorobiphenyl (PCB) spill on a state road in Southern Italy∗ , 1990 .

[35]  D. Phillips,et al.  Chlorinated hydrocarbon levels in human serum: Effects of fasting and feeding , 1989, Archives of environmental contamination and toxicology.

[36]  V. Aleandri,et al.  PCB and other organochlorine compounds in blood of women with or without miscarriage: a hypothesis of correlation. , 1989, Ecotoxicology and environmental safety.

[37]  L. Fabiani,et al.  [Assay of polychlorobiphenyls in human blood in relation to epidemiological studies]. , 1986, Il Farmaco; edizione pratica.

[38]  S. Focardi,et al.  PCB congeners, hexachlorobenzene, and organochlorine insecticides in human fat in Italy , 1986, Bulletin of environmental contamination and toxicology.

[39]  B. Gladen,et al.  Potential reproductive and postnatal morbidity from exposure to polychlorinated biphenyls: epidemiologic considerations. , 1985, Environmental health perspectives.

[40]  M. Ron,et al.  Serum levels of polychlorinated biphenyls and some organochlorine insecticides in women with recent and former missed abortions. , 1983, Environmental research.

[41]  S. Galassi,et al.  Chlorinated hydrocarbons in fish from the river Po (Italy). , 1981, The Science of the total environment.

[42]  R. Fanelli,et al.  Analytical response of single polychlorinated biphenyls analysed by selected ion monitoring , 1981 .

[43]  V. Leoni.  The separation of fifty pesticides and related compounds and polychlorobiphenyls into four groups by silica gel microcolumn chromatography. , 1971, Journal of chromatography.

[44]  B. Ahling,et al.  Reversed liquid-liquid partition in determination of polychlorinated biphenyl (PCB) and chlorinated pesticides in water. , 1970, Analytical chemistry.

[45]  S. Jensen,et al.  DDT and PCB in Marine Animals from Swedish Waters , 1969, Nature.

[46]  L. Henríquez-Hernández,et al.  Background levels of polychlorinated biphenyls in the population of the Canary Islands (Spain). , 2011, Environmental research.

[47]  M. Diamond,et al.  Concentrations and chiral signatures of POPs in soils and sediments: a comparative urban versus rural study in Canada and UK. , 2009, Chemosphere.

[48]  P. Apostoli,et al.  Metanalytical assessment of reference values for polychlorinated biphenyl in human blood. , 2004, Giornale italiano di medicina del lavoro ed ergonomia.

[49]  R. Duarte-Davidson,et al.  PCBs and other organochlorines in human tissue samples from the Welsh population: I--Adipose. , 1994, Environmental pollution.

[50]  V. Leoni,et al.  [Polychlorinated diphenyls (PCB) : industrial hygiene and environmental toxicology]. , 1978, Annali dell'Istituto Superiore di Sanità.