Numerical Modelling of Epidermal Wound Healing

A coupling between wound closure by cell migration and angiogenesis is presented here to model healing of epidermal wounds. The closure of the wound is modelled as a moving interface around which a local grid refinement is applied. The numerical solution combines finite element and finite difference methods to solve the coupled diffusion-reaction equations governing the physiological problem and the hyperbolic equations governing the motion of the interface.

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