To the editor: Age-sex–specific ranges of platelet count and all-cause mortality: prospective findings from the MOLI-SANI study

Platelet count has been reportedly associated in a nonlinear way with a number of health outcomes among older subjects 1,2 or in high-risk groups. 3 One early study has investigated the involvement of platelet count for cardiovascular mortality in a general middle-aged population of healthy men. 4 Platelet count decreases during aging, is higher in women than in men, 5,6 and varies in populations of different origin. 6,7 More recently, it has been reported that platelet count is also in fl uenced by dietary habits. 8 cells of patients with (HS) a de-creased surface-to-volume ratio, leading to their trapping and destruction

[1]  D. Tarng,et al.  U-shaped mortality curve associated with platelet count among older people: a community-based cohort study. , 2015, Blood.

[2]  P. Noris,et al.  Personalized reference intervals for platelet count reduce the number of subjects with unexplained thrombocytopenia , 2015, Haematologica.

[3]  S. Costanzo,et al.  Adherence to the Mediterranean diet is associated with lower platelet and leukocyte counts: results from the Moli-sani study. , 2014, Blood.

[4]  P. Gasparini,et al.  Age- And Sex-Related Variations in Platelet Count in Italy: A Proposal of Reference Ranges Based on 40987 Subjects' Data , 2013, PloS one.

[5]  S. Costanzo,et al.  Distribution of short and lifetime risks for cardiovascular disease in Italians , 2012, European journal of preventive cardiology.

[6]  P. Gasparini,et al.  Influence of age, sex and ethnicity on platelet count in five Italian geographic isolates: mild thrombocytopenia may be physiological , 2012, British journal of haematology.

[7]  F. Gianfagna,et al.  White blood cell count, sex and age are major determinants of heterogeneity of platelet indices in an adult general population: results from the MOLI-SANI project , 2011, Haematologica.

[8]  F. Murgia,et al.  Analysis of 12,517 inhabitants of a Sardinian geographic isolate reveals that predispositions to thrombocytopenia and thrombocytosis are inherited traits , 2011, Haematologica.

[9]  J. Maurer.  Thrombocytopenia and Thrombocytosis at Time of Hospitalization Predict Mortality in Patients With Community-Acquired Pneumonia , 2011 .

[10]  T. Lumley,et al.  Platelet count and the risk for thrombosis and death in the elderly , 2009, Journal of thrombosis and haemostasis : JTH.

[11]  J. Erikssen,et al.  Blood Platelet Count and Function Are Related to Total and Cardiovascular Death in Apparently Healthy Men , 1991, Circulation.