Breast cancer diagnosis using abnormalities on ipsilateral views of digital mammograms

Abstract Ipsilateral views of digital mammograms help radiologists to localize and confirm abnormal lesions during diagnosis of breast cancers. This study aims at developing algorithms which improve accuracy of computer-aided diagnosis (CADx) for analyzing breast abnormalities on ipsilateral views. The proposed system is a fusion of single and two view systems. Single view approach detects and characterizes suspicious lesions on craniocaudal (CC) and medio-lateral oblique (MLO) view separately using geometric and textural features. Lesions detected on each view are paired with potential lesions on another view. The proposed algorithm computes the correspondence score of each lesion pair. Single view information is fused with two views correspondence score to discriminate malignant tumours from benign masses using the SVM classifier. Performance of SVM classifier is assessed using five-fold cross validation (CV), Kappa metric and ROC analysis. Algorithms are applied to 110 pairs of mammograms from local dataset and 74 pairs from open dataset. Single view scheme yielded image-based sensitivity of 91.63% and 88.17% at 1.35 and 1.51 false positives per image (FPs/I) on local and open dataset respectively. Single view classification yielded FPs/I of 1.03 and 1.20 with sensitivity of 70%. Fusion based two views scheme using SVM classifier produced average case-based sensitivity of 75.91% at 0.69 FPs/I and 73.65% at 0.72 FPs/I on local and open dataset respectively. Fusion of single view features with two view correspondence score leads to improved case-based detection sensitivity. Proposed fusion based approach results into accurate and reliable diagnosis of breast abnormalities than single view approach.

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