An Analysis Scheme for Investigation of Effects of Various Parameters on Signals in Acoustic-Resolution Photoacoustic Microscopy of Mice Brain: a Simulation Study

Photoacoustic spectral analysis is a novel tool for studying various parameters affecting signals in Photoacoustic microscopy. But only observing frequency components of photoacoustic signals doesn't make enough data for a desirable analysis. Thus a hybrid time-domain and frequency-domain analysis scheme has been proposed to investigate effects of various parameters like depth of microscopy, laser focal spot size and contrast agent concentration on Photoacoustic signals.

[1]  B. Cornelissen,et al.  Micro-CT for Anatomic Referencing in PET and SPECT: Radiation Dose, Biologic Damage, and Image Quality , 2011, The Journal of Nuclear Medicine.

[2]  Liang Song,et al.  Delay-multiply-and-sum-based synthetic aperture focusing in photoacoustic microscopy , 2016, Journal of biomedical optics.

[3]  C. L. Kuo,et al.  High-Resolution Observations of the Cosmic Microwave Background Power Spectrum with ACBAR , 2002, astro-ph/0212289.

[4]  Frank K. Tittel,et al.  Laser optoacoustic tomography for medical diagnostics: principles , 1996, Photonics West.

[5]  Christos Haritoglou,et al.  Retinal damage from indocyanine green in experimental macular surgery. , 2003, Investigative ophthalmology & visual science.

[6]  Geng Ku,et al.  Noninvasive photoacoustic angiography of animal brains in vivo with near-infrared light and an optical contrast agent. , 2004, Optics letters.

[7]  Manojit Pramanik,et al.  Switchable Acoustic and Optical Resolution Photoacoustic Microscopy for In Vivo Small-animal Blood Vasculature Imaging. , 2017, Journal of visualized experiments : JoVE.

[8]  A. Oraevsky,et al.  Laser optoacoustic imaging system for detection of breast cancer. , 2009, Journal of biomedical optics.

[9]  Ramanik,et al.  In vivo studies of transdermal nanoparticle delivery with microneedles using photoacoustic microscopy , 2019 .

[10]  S. Emelianov,et al.  Detection of lipid in atherosclerotic vessels using ultrasound-guided spectroscopic intravascular photoacoustic imaging , 2010, Optics express.

[11]  Chao Tao,et al.  Evaluation of microvasculature diameter in deep tissue using a photoacoustic spectral analysis , 2015, 2015 Opto-Electronics and Communications Conference (OECC).

[12]  Rui Cao,et al.  Photoacoustic microscopy of cerebral hemodynamic and oxygen-metabolic responses to anesthetics , 2017, BiOS.

[13]  Xianjin Dai,et al.  Wearable 3-D Photoacoustic Tomography for Functional Brain Imaging in Behaving Rats , 2016, Scientific Reports.

[14]  P. Welch The use of fast Fourier transform for the estimation of power spectra: A method based on time averaging over short, modified periodograms , 1967 .

[15]  Mark A. Anastasio,et al.  Photoacoustic tomography through a whole adult human skull with a photon recycler , 2012, Journal of biomedical optics.

[16]  Sun,et al.  Photoacoustic monopole radiation in one, two, and three dimensions. , 1991, Physical review letters.

[17]  H. Nussbaumer Fast Fourier transform and convolution algorithms , 1981 .

[18]  Stanislav Y. Emelianov,et al.  Photoacoustic imaging of prostate brachytherapy seeds , 2011, Biomedical optics express.

[19]  Lihong V. Wang,et al.  Tutorial on Photoacoustic Microscopy and Computed Tomography , 2008, IEEE Journal of Selected Topics in Quantum Electronics.

[20]  Cheri X Deng,et al.  Frequency-domain analysis of photoacoustic imaging data from prostate adenocarcinoma tumors in a murine model. , 2011, Ultrasound in medicine & biology.

[21]  Yan Wang,et al.  Photoacoustic tomography based on a novel linear array ultrasound transducer configuration , 2017, 2017 IEEE International Instrumentation and Measurement Technology Conference (I2MTC).

[22]  B T Cox,et al.  A first-order k-space model for elastic wave propagation in heterogeneous media. , 2011, The Journal of the Acoustical Society of America.

[23]  Eric Clarkson,et al.  Three-dimensional Neumann-series approach to model light transport in nonuniform media. , 2012, Journal of the Optical Society of America. A, Optics, image science, and vision.

[24]  Puxiang Lai,et al.  Photoacoustic imaging in oxygen detection , 2017 .

[25]  Alexei V. Demchenko,et al.  Noninvasive photoacoustic computed tomography of mouse brain metabolism in vivo , 2013, Photonics West - Biomedical Optics.

[26]  S. Arridge,et al.  Coupled radiative transfer equation and diffusion approximation model for photon migration in turbid medium with low-scattering and non-scattering regions , 2005, Physics in medicine and biology.

[27]  Qian Huang,et al.  Copper sulfide nanoparticles as a new class of photoacoustic contrast agent for deep tissue imaging at 1064 nm. , 2012, ACS nano.

[28]  Lihong V. Wang,et al.  High-speed label-free functional photoacoustic microscopy of mouse brain in action , 2015, Nature Methods.

[29]  S. Emelianov,et al.  Photoacoustic imaging in cancer detection, diagnosis, and treatment guidance. , 2011, Trends in biotechnology.

[30]  Manojit Pramanik,et al.  In vivo studies of transdermal nanoparticle delivery with microneedles using photoacoustic microscopy. , 2017, Biomedical optics express.

[31]  Da-Kang Yao,et al.  Photoacoustic measurement of the Grüneisen parameter of tissue , 2014, Journal of biomedical optics.

[32]  Jie Yuan,et al.  Characterizing cellular morphology by photoacoustic spectrum analysis with an ultra-broadband optical ultrasonic detector. , 2016, Optics express.

[33]  B T Cox,et al.  k-Wave: MATLAB toolbox for the simulation and reconstruction of photoacoustic wave fields. , 2010, Journal of biomedical optics.