Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance.

[1]  Xin Hu,et al.  TRPA1–FGFR2 binding event is a regulatory oncogenic driver modulated by miRNA-142-3p , 2017, Nature Communications.

[2]  P. Delvenne,et al.  Methylglyoxal-Mediated Stress Correlates with High Metabolic Activity and Promotes Tumor Growth in Colorectal Cancer , 2017, International journal of molecular sciences.

[3]  A. Richardson,et al.  CDK12 Inhibition Reverses De Novo and Acquired PARP Inhibitor Resistance in BRCA Wild-Type and Mutated Models of Triple-Negative Breast Cancer. , 2016, Cell reports.

[4]  A. Ramanathan,et al.  A Caenorhabditis elegans Model Elucidates a Conserved Role for TRPA1-Nrf Signaling in Reactive α-Dicarbonyl Detoxification , 2016, Current Biology.

[5]  M. Ferrer,et al.  Small Molecule Inhibitor of NRF2 Selectively Intervenes Therapeutic Resistance in KEAP1-Deficient NSCLC Tumors. , 2016, ACS chemical biology.

[6]  N. Zhong,et al.  Cigarette smoke extract (CSE) induces transient receptor potential ankyrin 1(TRPA1) expression via activation of HIF1αin A549 cells. , 2016, Free radical biology & medicine.

[7]  Brandon Da Silva,et al.  NRF2 Promotes Tumor Maintenance by Modulating mRNA Translation in Pancreatic Cancer , 2016, Cell.

[8]  Christian M. Metallo,et al.  Reductive carboxylation supports redox homeostasis during anchorage-independent growth , 2016, Nature.

[9]  Qifu Li,et al.  Cancer drug resistance: redox resetting renders a way , 2016, Oncotarget.

[10]  Maelíosa T. C. McCrudden,et al.  Biodentine Reduces Tumor Necrosis Factor Alpha-induced TRPA1 Expression in Odontoblastlike Cells. , 2016, Journal of endodontics.

[11]  Stephanie D. Geuns-Meyer,et al.  Optimization of a Novel Quinazolinone-Based Series of Transient Receptor Potential A1 (TRPA1) Antagonists Demonstrating Potent in Vivo Activity. , 2016, Journal of medicinal chemistry.

[12]  S. Shin,et al.  Data-driven Analysis of TRP Channels in Cancer: Linking Variation in Gene Expression to Clinical Significance. , 2016, Cancer genomics & proteomics.

[13]  R. Deberardinis,et al.  NRF2 regulates serine biosynthesis in non-small cell lung cancer , 2015, Nature Genetics.

[14]  M. Bergo,et al.  Antioxidants can increase melanoma metastasis in mice , 2015, Science Translational Medicine.

[15]  N. Déliot,et al.  Plasma membrane calcium channels in cancer: Alterations and consequences for cell proliferation and migration. , 2015, Biochimica et biophysica acta.

[16]  R. Deberardinis,et al.  Oxidative stress inhibits distant metastasis by human melanoma cells , 2015, Nature.

[17]  N. Zhong,et al.  Effects of Schisandra chinensis extracts on cough and pulmonary inflammation in a cough hypersensitivity guinea pig model induced by cigarette smoke exposure. , 2015, Journal of ethnopharmacology.

[18]  S. Inoue,et al.  Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression. , 2015, Cancer cell.

[19]  T. Tuccinardi,et al.  Steroidal and non-steroidal third-generation aromatase inhibitors induce pain-like symptoms via TRPA1 , 2014, Nature Communications.

[20]  Neville E. Sanjana,et al.  Improved vectors and genome-wide libraries for CRISPR screening , 2014, Nature Methods.

[21]  N. Chandel,et al.  ROS Function in Redox Signaling and Oxidative Stress , 2014, Current Biology.

[22]  Xiaoman Li,et al.  H3K4me2 reliably defines transcription factor binding regions in different cells. , 2014, Genomics.

[23]  Y. Mori,et al.  TRPs as chemosensors (ROS, RNS, RCS, gasotransmitters). , 2014, Handbook of experimental pharmacology.

[24]  T. Mak,et al.  Modulation of oxidative stress as an anticancer strategy , 2013, Nature Reviews Drug Discovery.

[25]  G. Piazza,et al.  An Undesired Effect of Chemotherapy , 2013, The Journal of Biological Chemistry.

[26]  Takafumi Suzuki,et al.  Toward clinical application of the Keap1-Nrf2 pathway. , 2013, Trends in pharmacological sciences.

[27]  Yuka Itoh,et al.  Hypoxia-inducible Factor-1α (HIF1α) Switches on Transient Receptor Potential Ankyrin Repeat 1 (TRPA1) Gene Expression via a Hypoxia Response Element-like Motif to Modulate Cytokine Release* , 2012, The Journal of Biological Chemistry.

[28]  H. Aburatani,et al.  Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming. , 2012, Cancer cell.

[29]  P. Nawroth,et al.  Methylglyoxal Activates Nociceptors through Transient Receptor Potential Channel A1 (TRPA1) , 2012, The Journal of Biological Chemistry.

[30]  Tsung-Han Hsieh,et al.  Expression of Transient Receptor Potential Ankyrin 1 (TRPA1) and Its Role in Insulin Release from Rat Pancreatic Beta Cells , 2012, PloS one.

[31]  L. Galluzzi,et al.  Molecular mechanisms of cisplatin resistance , 2012, Oncogene.

[32]  M. Hung,et al.  Regulation of Ubiquitination-Mediated Protein Degradation by Survival Kinases in Cancer , 2011, Front. Oncol..

[33]  A. Pertovaara,et al.  Inhibiting TRPA1 ion channel reduces loss of cutaneous nerve fiber function in diabetic animals: sustained activation of the TRPA1 channel contributes to the pathogenesis of peripheral diabetic neuropathy. , 2012, Pharmacological research.

[34]  Mark T. W. Ebbert,et al.  Tumor grafts derived from women with breast cancer authentically reflect tumor pathology, growth, metastasis and disease outcomes , 2011, Nature Medicine.

[35]  P. Carmeliet,et al.  TRPA1 underlies a sensing mechanism for O2. , 2011, Nature chemical biology.

[36]  Scott E. Kern,et al.  Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis , 2011, Nature.

[37]  B. Nilius,et al.  Oxaliplatin elicits mechanical and cold allodynia in rodents via TRPA1 receptor stimulation , 2011, PAIN®.

[38]  Y. Soini,et al.  8-hydroxydeguanosine and nitrotyrosine are prognostic factors in urinary bladder carcinoma. , 2011, International journal of clinical and experimental pathology.

[39]  K. Coombes,et al.  A Technical Assessment of the Utility of Reverse Phase Protein Arrays for the Study of the Functional Proteome in Non-microdissected Human Breast Cancers , 2010, Clinical Proteomics.

[40]  E. Gottlieb,et al.  Targeting metabolic transformation for cancer therapy , 2010, Nature Reviews Cancer.

[41]  Hanna Y. Irie,et al.  Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment , 2009, Nature.

[42]  G. Page,et al.  Integrative genomic analyses of neurofibromatosis tumours identify SOX9 as a biomarker and survival gene , 2009, EMBO molecular medicine.

[43]  Nathaniel D. Heintzman,et al.  Histone modifications at human enhancers reflect global cell-type-specific gene expression , 2009, Nature.

[44]  C. Akgul.  Mcl-1 is a potential therapeutic target in multiple types of cancer , 2009, Cellular and Molecular Life Sciences.

[45]  D. Clapham,et al.  Calcium Signaling , 2007, Cell.

[46]  R. Rawal,et al.  Lipid Peroxidation, Total Antioxidant Status, and Total Thiol Levels Predict Overall Survival in Patients With Oral Squamous Cell Carcinoma , 2007, Integrative cancer therapies.

[47]  Evan W. Miller,et al.  Molecular imaging of hydrogen peroxide produced for cell signaling , 2007 .

[48]  A. Strasser,et al.  BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanisms. , 2007, Developmental cell.

[49]  Peter G. Schultz,et al.  Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines , 2007, Nature.

[50]  D. Julius,et al.  TRP channel activation by reversible covalent modification , 2006, Proceedings of the National Academy of Sciences.

[51]  Jayanta Debnath,et al.  Modelling glandular epithelial cancers in three-dimensional cultures , 2005, Nature Reviews Cancer.

[52]  D. McKemy,et al.  Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1 , 2004, Nature.

[53]  David E. Clapham,et al.  TRP channels as cellular sensors , 2003, Nature.

[54]  Dennis C. Sgroi,et al.  Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis , 2003, Nature Cell Biology.

[55]  Peter J. Cullen,et al.  Integration of calcium and RAS signalling , 2002, Nature Reviews Molecular Cell Biology.