The first batteryless, solar-powered cardiac pacemaker.

BACKGROUND Contemporary pacemakers (PMs) are powered by primary batteries with a limited energy-storing capacity. PM replacements because of battery depletion are common and unpleasant and bear the risk of complications. Batteryless PMs that harvest energy inside the body may overcome these limitations. OBJECTIVE The goal of this study was to develop a batteryless PM powered by a solar module that converts transcutaneous light into electrical energy. METHODS Ex vivo measurements were performed with solar modules placed under pig skin flaps exposed to different irradiation scenarios (direct sunlight, shade outdoors, and indoors). Subsequently, 2 sunlight-powered PMs featuring a 4.6-cm(2) solar module were implanted in vivo in a pig. One prototype, equipped with an energy buffer, was run in darkness for several weeks to simulate a worst-case scenario. RESULTS Ex vivo, median output power of the solar module was 1963 μW/cm(2) (interquartile range [IQR] 1940-2107 μW/cm(2)) under direct sunlight exposure outdoors, 206 μW/cm(2) (IQR 194-233 μW/cm(2)) in shade outdoors, and 4 μW/cm(2) (IQR 3.6-4.3 μW/cm(2)) indoors (current PMs use approximately 10-20 μW). Median skin flap thickness was 4.8 mm. In vivo, prolonged SOO pacing was performed even with short irradiation periods. Our PM was able to pace continuously at a rate of 125 bpm (3.7 V at 0.6 ms) for 1½ months in darkness. CONCLUSION Tomorrow's PMs might be batteryless and powered by sunlight. Because of the good skin penetrance of infrared light, a significant amount of energy can be harvested by a subcutaneous solar module even indoors. The use of an energy buffer allows periods of darkness to be overcome.

[1]  J. Harbinson,et al.  An artificial solar spectrum substantially alters plant development compared with usual climate room irradiance spectra. , 2010, Journal of experimental botany.

[2]  T. O'Donnell,et al.  Energy scavenging for long-term deployable wireless sensor networks. , 2008, Talanta.

[3]  John M. Morgan,et al.  Abstract 2165: Harvesting the Energy of Cardiac Motion to Power a Pacemaker , 2008 .

[4]  Shiro Nishiwaki,et al.  Highly efficient Cu(In,Ga)Se2 solar cells grown on flexible polymer films. , 2011, Nature materials.

[5]  A. N. Bashkatov,et al.  Optical properties of human skin, subcutaneous and mucous tissues in the wavelength range from 400 to 2000 nm , 2005 .

[6]  Christoph Huber,et al.  Successful pacing using a batteryless sunlight-powered pacemaker. , 2014, Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology.

[7]  Matthias Maluck.  Replikationstechniken zur Herstellung einmodiger integriert-optischer Komponenten aus neuartigen und kommerziellen Polymeren , 2007 .

[8]  Eichi Iwazawa,et al.  Optimum Selection of an Implantable Secondary Battery for an Artificial Heart by Examination of the Cycle Life Test , 2002, ASAIO journal.

[9]  Lloyd H. Michael,et al.  The Guide for the Care and Use of Laboratory Animals. , 2016, ILAR journal.

[10]  M. Yudasaka,et al.  A photo-thermal-electrical converter based on carbon nanotubes for bioelectronic applications. , 2011, Angewandte Chemie.

[11]  Thierry Aellen,et al.  Protective multilayer packaging for long-term implantable medical devices , 2014 .

[12]  Chris Van Hoof,et al.  Realization of a wearable miniaturized thermoelectric generator for human body applications , 2009 .

[13]  Rolf Vogel,et al.  Performance analysis of a miniature turbine generator for intracorporeal energy harvesting. , 2014, Artificial organs.

[14]  S. Vandenberghe,et al.  Energy Harvesting from the Beating Heart by a Mass Imbalance Oscillation Generator , 2012, Annals of Biomedical Engineering.

[15]  L.S.Y. Wong,et al.  A very low-power CMOS mixed-signal IC for implantable pacemaker applications , 2004, IEEE Journal of Solid-State Circuits.

[16]  H. Mond,et al.  The 11th World Survey of Cardiac Pacing and Implantable Cardioverter‐Defibrillators: Calendar Year 2009–A World Society of Arrhythmia's Project , 2011, Pacing and clinical electrophysiology : PACE.

[17]  Heinrich Häberlin.  Photovoltaics: System Design and Practice , 2012 .

[18]  J. F. Randall,et al.  Is AM1.5 applicable in practice? Modelling eight photovoltaic materials with respect to light intensity and two spectra , 2003 .