Elevated neutrophil function in chronic neutrophilic leukemia

A 65‐year‐old man with marked leukocytosis was admitted for diagnosis and treatment. His peripheral blood leukocyte count was 37,500/μI and the leukocytes consisted of mature neutrophil‐like cells. A high neutrophil alkaline phosphatase score and a normal bone marrow cell karyotype suggested that the patient had chronic neutrophilic leukemia rather than chronic myeloid leukemia. Several neutrophil functions, such as superoxide production, nitroblue tetrazolium reduction activity, and phagocytosis, were elevated. These data and the morphological features (toxic granules and Döhle bodies) indicated that the patient's neutrophils were in an activated stage. © 1992 Wiley‐Liss, Inc.

[1]  R. Luksch,et al.  Polycythemia vera terminating in chronic neutrophilic leukemia: Report of a case , 1990, American journal of hematology.

[2]  M. Wagstaff,et al.  Chronic neutrophilic leukemia and multiple myeloma: An association with λ light chain expression , 1990, Cancer.

[3]  A. Arnold,et al.  Clinically nonfunctioning pituitary tumors are monoclonal in origin. , 1990, The Journal of clinical investigation.

[4]  C. Rozman,et al.  Chronic neutrophilic leukaemia preceding for seven years the development of multiple myeloma. , 1990, Acta haematologica.

[5]  M. Rozman,et al.  Chronic neutrophilic leukemia with dysplastic features. , 1990, Acta Haematologica.

[6]  H. Koga,et al.  The discrepancy between chemotaxis and leukotriene B4 production in a patient with chronic neutrophilic leukemia. , 1989, Japanese journal of medicine.

[7]  G. Lugassy,et al.  Chronic neutrophilic leukemia associated with polycythemia vera , 1989, American journal of hematology.

[8]  S. Kamachi,et al.  Quantitative enzyme immunoassay for human granulocyte colony stimulating factor (G-CSF). , 1989, Journal of immunological methods.

[9]  A. Symeonidis,et al.  Chronic Neutrophilic Leukemia with Dysplastic Features , 1989 .

[10]  G. Cattoretti,et al.  A case of chronic neutrophilic leukemia with trisomy 8. , 1989, Acta haematologica.

[11]  H. Koeffler,et al.  Identification of neutrophil alkaline phosphatase‐inducing factor in cystic fluid of a human squamous cell carcinoma as granulocyte colony‐stimulating factor , 1988, Journal of cellular physiology.

[12]  J. García-Alegría,et al.  A case of chronic neutrophilic leukemia with original chromosomal abnormalities , 1988, European journal of haematology.

[13]  J. Starakis,et al.  κ LIGHT CHAIN MYELOMA DEVELOPING IN A PATIENT WITH CHRONIC NEUTROPHILIC LEUKAEMIA , 1987, British journal of haematology.

[14]  K. Saigo,et al.  Neutrophils with ring-shaped nuclei in chronic neutrophilic leukemia. , 1986, American journal of clinical pathology.

[15]  D. Boggs,et al.  Cytobiologic and clinical aspects in a patient with chronic neutrophilic leukemia after thorotrast exposure. , 1986, The American journal of medicine.

[16]  M. Coleman,et al.  An association between chronic neutrophilic leukaemia and multiple myeloma with a study of cobalamin‐binding proteins , 1986, British journal of haematology.

[17]  G. Croci,et al.  Chronic neutrophilic leukemia: description of a new case with karyotypic abnormalities. , 1986, American journal of clinical pathology.

[18]  D. Winfield,et al.  Cellular abnormalities and reduced colony-forming cells in chronic neutrophilic leukaemia. , 1985, Acta haematologica.

[19]  A. Watanabe,et al.  A Case of Chronic Neutrophilic Leukemia with Paraproteinemia (IgG Type λ and IgA Type K) , 1984 .

[20]  J. Stephenson,et al.  Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22 , 1984, Cell.

[21]  M. Seeds,et al.  Flow cytometric studies of oxidative product formation by neutrophils: a graded response to membrane stimulation. , 1983, Journal of immunology.

[22]  L. Marcelis,et al.  Chronic neutrophilic leukaemia with enlarged lymph nodes and lysozyme deficiency , 1983, Journal of clinical pathology.

[23]  W. Pruzanski,et al.  Functional characterization of the cells in chronic neutrophilic leukemia , 1982, American journal of hematology.

[24]  J. Steinkamp,et al.  Phagocytosis: flow cytometric quantitation with fluorescent microspheres. , 1982, Science.

[25]  M. Sanz.  Long-term survival in chronic neutrophilic leukemia. , 1980, American Journal of Clinical Pathology.

[26]  I. M. Weisbrot,et al.  Chronic neutrophilic leukemia. Report of two cases and review of the literature. , 1979, American journal of clinical pathology.

[27]  C. McCall,et al.  Independent stimulation of motility and the oxidative metabolic burst of human polymorphonuclear leukocytes. , 1978, Journal of immunology.

[28]  D. Vorobiof,et al.  Chronic granulocytic leukemia, neutrophilic type, with paraproteinemia (IgA type K). , 1978, Acta haematologica.

[29]  A. Shibata,et al.  Neutrophilic leukemia and blastic crisis. , 1977, Annals of internal medicine.

[30]  T. Papayannopoulou,et al.  Chronic myelocytic leukemia: clonal origin in a stem cell common to the granulocyte, erythrocyte, platelet and monocyte/macrophage. , 1977, The American journal of medicine.

[31]  Silberstein Eb,et al.  Letter: Neutrophilic leukemia. , 1974 .

[32]  C. Stewart.  LEUCOCYTE ALKALINE PHOSPHATASE IN MYELOID MATURATION , 1974, Pathology.

[33]  D. Nathan,et al.  Quantitative nitroblue tetrazolium test in chronic granulomatous disease. , 1968, The New England journal of medicine.

[34]  H. Rubin.  Chronic neutrophilic leukemia. , 1966, Annals of internal medicine.