Polymethylhydrosiloxane (PMHS) as a functional material for microfluidic chips

Polymethylhydrosiloxane (PMHS) has been investigated as a candidate material for microfluidic chips. The ability to modify the surface of PMHS by hydrosilation is particularly advantageous for separation processes. The chemical modification of PMHS is verified by diffuse reflectance infrared Fourier transform (DRIFT) analysis, and the modified PMHS is shown to be stable when exposed to extreme pH conditions between 2 and 9. Spectrophotometer measurements show that PMHS exhibits over 40% transmittance for ultraviolet (UV) wavelength as low as 220 nm, indicating viability for sensor applications based on UV absorption. The UV transmittance is furthermore observed to be insensitive to thickness for specimens tested between 1.6 mm and 6.4 mm thick. Full curing of PMHS liquid resin occurs between 48 and 72 h at 110 °C with no secondary additives. Casting of microscale features is achieved by using soft lithography methods similar to established techniques for fabrication based on polydimethylsiloxane (PDMS). Microchannels approximately 100 µm wide and 50 µm deep are also demonstrated by carbon dioxide laser ablation, with uniform channels produced using an energy dose of 0.2 mJ mm−1 with respect to line length. Other basic functional requirements for microfluidic chips are discussed, including the ability to bond PMHS substrates by plasma treatment.

[1]  P. Abgrall,et al.  Lab-on-chip technologies: making a microfluidic network and coupling it into a complete microsystem—a review , 2007 .

[2]  Satoshi Konishi,et al.  Fabrication and drive test of pneumatic PDMS micro pump , 2007 .

[3]  N. Sundararajan,et al.  Characterization of laterally deformable elastomer membranes for microfluidics , 2007 .

[4]  Zhifang Fan,et al.  Device fabrication and integration with photodefinable microvalves for protein separation , 2007 .

[5]  P. H. Yap,et al.  Design, simulation and experiment of electroosmotic microfluidic chip for cell sorting , 2007 .

[6]  R. Zengerle,et al.  Rapid prototyping of microfluidic chips in COC , 2007 .

[7]  Jikun Liu,et al.  Permanent surface modification of polymeric capillary electrophoresis microchips for protein and peptide analysis , 2006, Electrophoresis.

[8]  S. Piccarolo,et al.  Nanoscale Mechanical Characterization of Polymers by AFM Nanoindentations: Critical Approach to the Elastic Characterization , 2006 .

[9]  C. Culbertson,et al.  Surface engineering of poly(dimethylsiloxane) microfluidic devices using transition metal sol-gel chemistry. , 2006, Langmuir : the ACS journal of surfaces and colloids.

[10]  Zuo Tie-chuan,et al.  Surface roughness analysis and improvement of micro-fluidic channel with excimer laser , 2006 .

[11]  Tong-Yi Zhang,et al.  Mechanical properties of silicone elastomer on temperature in biomaterial application , 2005 .

[12]  J. Berg,et al.  Studies on surface wettability of poly(dimethyl) siloxane (PDMS) and glass under oxygen-plasma treatment and correlation with bond strength , 2005, Journal of Microelectromechanical Systems.

[13]  H. Yin,et al.  Microfluidic chip for peptide analysis with an integrated HPLC column, sample enrichment column, and nanoelectrospray tip. , 2005, Analytical chemistry.

[14]  R. Oleschuk,et al.  Chemical force titrations of amine- and sulfonic acid-modified poly(dimethylsiloxane). , 2005, Langmuir.

[15]  Z Hugh Fan,et al.  Macro-to-micro interfaces for microfluidic devices. , 2004, Lab on a chip.

[16]  N. Sundararajan,et al.  Three-dimensional hydrodynamic focusing in polydimethylsiloxane (PDMS) microchannels , 2004, Journal of Microelectromechanical Systems.

[17]  Kin Fong Lei,et al.  Microfluidic channel fabrication by PDMS-interface bonding , 2004, SPIE Micro + Nano Materials, Devices, and Applications.

[18]  Di Chen,et al.  Ultraviolet sealing and poly(dimethylacrylamide) modification for poly(dimethylsiloxane)/glass microchips , 2004, Electrophoresis.

[19]  M. Wirth,et al.  Surface modification of the channels of poly(dimethylsiloxane) microfluidic chips with polyacrylamide for fast electrophoretic separations of proteins. , 2004, Analytical chemistry.

[20]  K D Altria,et al.  Overview of the status and applications of capillary electrophoresis to the analysis of small molecules. , 2004, Journal of chromatography. A.

[21]  Gwo-Bin Lee,et al.  Poly(dimethylsiloxane)‐based microfluidic device with electrospray ionization‐mass spectrometry interface for protein identification , 2003, Electrophoresis.

[22]  Jin Ho Kim,et al.  Surface modification of poly(dimethylsiloxane) microchannels , 2003, Electrophoresis.

[23]  Nancy Allbritton,et al.  Cross‐linked coatings for electrophoretic separations in poly(dimethylsiloxane) microchannels , 2003, Electrophoresis.

[24]  Bin Wang,et al.  Aging Effects on Oxidized and Amine-Modified Poly(dimethylsiloxane) Surfaces Studied with Chemical Force Titrations: Effects on Electroosmotic Flow Rate in Microfluidic Channels , 2003 .

[25]  John A Rogers,et al.  A photocurable poly(dimethylsiloxane) chemistry designed for soft lithographic molding and printing in the nanometer regime. , 2003, Journal of the American Chemical Society.

[26]  Mary J. Wirth,et al.  Chemical modification of the surface of poly(dimethylsiloxane) by atom-transfer radical polymerization of acrylamide , 2002 .

[27]  F. Regnier,et al.  Capillary electrochromatography of peptides on microfabricated poly(dimethylsiloxane) chips modified by cerium(IV)-catalyzed polymerization. , 2002, Journal of chromatography. A.

[28]  H. Becker,et al.  Polymer microfluidic devices. , 2002, Talanta.

[29]  Maria T. Matyska-Pesek,et al.  Open tubular capillary electrokinetic chromatography in etched fused-silica tubes. , 2000, Journal of chromatography. A.

[30]  Pullen,et al.  Characterization by atomic force microscopy of fused-silica capillaries chemically modified for capillary electrokinetic chromatography , 2000, Analytical chemistry.

[31]  N. Lawrence,et al.  Polymethylhydrosiloxane: a versatile reducing agent for organic synthesis , 2000 .

[32]  D. Beebe,et al.  Three-dimensional micro-channel fabrication in polydimethylsiloxane (PDMS) elastomer , 2000, Journal of Microelectromechanical Systems.

[33]  G. Whitesides,et al.  Rapid prototyping of microfluidic switches in poly(dimethyl siloxane) and their actuation by electro-osmotic flow , 1999 .

[34]  G. Whitesides,et al.  Rapid Prototyping of Microfluidic Systems in Poly(dimethylsiloxane). , 1998, Analytical chemistry.

[35]  M. Matyska,et al.  Synthesis and characterization of alkyl bonded phases from a silica hydride via hydrosilation with free radical initiation , 1997 .

[36]  P. Veltink,et al.  The mechanical properties of the rubber elastic polymer polydimethylsiloxane for sensor applications , 1997 .

[37]  J. Pesek.  Hydride-based Surface Materials for HPLC, HPCE and Electrochromatography , 1996 .

[38]  J. Pesek,et al.  A New Approach for the Preparation of a Hydride-Modified Substrate Used as an Intermediate in the Synthesis of Surface-Bonded Materials , 1993 .

[39]  H. Claessens,et al.  The influence of surface treatments on the electroosmotic flow in micellar electrokinetic capillary chromatography , 1992 .

[40]  R. O. Sauer,et al.  Derivatives of the Methylchlorosilanes. V. Polysiloxanes from Methyldichlorosilane , 1946 .

[41]  Sang Joon John Lee,et al.  Fabrication Process Development and Characterization of Polymethylhydrosiloxane (PMHS) for Surface-Modified Microfluidic Chips , 2007 .

[42]  Jr-Lung Lin,et al.  Active micro-mixers utilizing moving wall structures activated pneumatically by buried side chambers , 2006 .

[43]  R. Horng,et al.  PMMA-based capillary electrophoresis electrochemical detection microchip fabrication , 2005 .

[44]  G. Whitesides,et al.  Fabrication of microfluidic systems in poly(dimethylsiloxane) , 2000, Electrophoresis.