Are Patients With Autoimmune Disease at Greater Risk of Developing Severe COVID-19?

The novel coronavirus disease 2019 (COVID-19) outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was declared a pandemic in early 2020, affecting mostly middle-aged and older population irrespectively of their medical background. Individuals with autoimmune inflammatory diseases are at greatly morbidity and mortality risk due to infectious diseases, so it was hypothesized that they would be at increased risk of severe complications from SARS-CoV-2 infection as well. These individuals are considered to be at high risk for developing serious infections due to their underlying conditions and the use of targeted immune-modulating drugs such as biologic agents. In particular, data on COVID-19 patients with immune-mediated inflammatory disease are scarce [1-3]. We report a retrospective case series referring to patients who were diagnosed with COVID-19 infection and had known autoimmune inflammatory disease. All infected patients who visited the Emergency Department of University Hospital of Patras, Western Greece, during the first month period since the recording of the first case, were enrolled in the study. The study period was from March 3, 2020 until April 3, 2020.We recorded the demographic characteristics, clinical findings, laboratory parameters and outcome of patients who had immunemediated inflammatory disease with symptomatic COVID-19 infection and compared them with the age and gender matched group of patients who visited our hospital due to symptomatic COVID-19 infection and did not suffer from any autoimmune disease. All the above parameters are shown in Table 1. This study was conducted in compliance with the ethical standards of the responsible institution on human subjects as well as with the Helsinki Declaration. Ten patients with autoimmune inflammatory disease presented to the Emergency Department with clinical symptoms of SARS-CoV-2 infection. Seven of them, due to disease severity were hospitalized (group 1); three patients had a diagnosis of multiple sclerosis (MS), two had rheumatoid arthritis (RA), four with Hashimoto thyroiditis and one with psoriatic arthritis. Of these patients, four were receiving immunemodulatory therapies (interferon α, anti-tumor necrosis factor (TNF)-α, anti-interleukin 6 (IL-6)), and one was receiving hydroxychloroquine. All patients with Hashimoto thyroiditis were treated with levothyroxine. At the same period, an age and gender matched group of 14 patients without any known history of immune disease were hospitalized with SARSCoV-2 infection (group 2). No significant differences were identified on clinical examination of the two group patients. All patients were alert and orientated, were cardiovascular stable and expressed a similar clinical pattern from the respiratory system with mild dyspnea (oxygen saturation (SaO2) 92-95% in room air), fever (37.8 38.6 °C), non-productive cough and chest pain. Most of the hospitalized patients with autoimmune inflammatory disease (6/7) were treated with supplemental oxygen, either with simple nasal cannula or Venturi face mask, and only one received non-invasive ventilation for acute respiratory distress syndrome. Parameters from peripheral blood samples including lymphocyte absolute count (ALC), fibrinogen, Ddimers, lactate dehydrogenase (LDH) and ferritin levels were measured. We also calculated the duration of hospitalization and the mortality rate in both groups. Our study did not reveal any statistically significant longer hospitalization for the group of patients with immune-mediated inflammatory disease (P = 0.771). In regards to the laboratory parameters that have been suggested as prognostic factors for COVID-19 infection (ferritin, D-dimers, lymphocytes, fibrinogen and LDH), we did not find statistically significant differences between the two groups (P = 0.800, P = 0.667, P = 0.445, P = 0.114 and P = 0.945, respectively). Furthermore, the presence of lung infiltrates as well as the need for oxygen treatment was not significantly different in the comparison of the two groups (P = 0.552 and P = 0.626, respectively). All of the patients with immune-mediated inflammatory disease who were hospitalized had a good outcome and were discharged. The mean duration of hospitalization was not longer for patients receiving immunomodulatory therapies compared to those who were not (7.14 ± 2.6 vs 8 ± 3.1 days). Patients with respiratory distress caused by SARS-CoV-2 display hyper-inflammatory responses with features of either Manuscript submitted June 2, 2020, accepted June 16, 2020 Published online July 22, 2020