The tumor suppressor PTEN inhibits EGF-induced TSP-1 and TIMP-1 expression in FTC-133 thyroid carcinoma cells.

[1]  Minhyung Lee,et al.  Sp1‐dependent regulation of the tissue inhibitor of metalloproteinases‐1 promoter , 2004, Journal of cellular biochemistry.

[2]  D. Trisciuoglio,et al.  bcl-2 Induction of Urokinase Plasminogen Activator Receptor Expression in Human Cancer Cells through Sp1 Activation , 2004, Journal of Biological Chemistry.

[3]  W. Hornebeck,et al.  Tissue inhibitor of metalloproteinases-1 signalling pathway leading to erythroid cell survival. , 2003, The Biochemical journal.

[4]  R. Weinberg,et al.  Ras modulates Myc activity to repress thrombospondin-1 expression and increase tumor angiogenesis. , 2003, Cancer cell.

[5]  M. Suckow,et al.  Thrombospondin 1--a regulator of adenoma growth and carcinoma progression in the APC(Min/+) mouse model. , 2003, Carcinogenesis.

[6]  O. Volpert,et al.  Id1 regulates angiogenesis through transcriptional repression of thrombospondin-1. , 2002, Cancer cell.

[7]  S. Park,et al.  PTEN suppresses hyaluronic acid-induced matrix metalloproteinase-9 expression in U87MG glioblastoma cells through focal adhesion kinase dephosphorylation. , 2002, Cancer research.

[8]  Y. Yamashita,et al.  Opposite effects of thrombospondin-1 via CD36 and CD47 on homotypic aggregation of monocytic cells. , 2002, Matrix biology : journal of the International Society for Matrix Biology.

[9]  J. Kurebayashi,et al.  Inhibition of infiltration and angiogenesis by thrombospondin-1 in papillary thyroid carcinoma. , 2002, Clinical cancer research : an official journal of the American Association for Cancer Research.

[10]  K. Sugimachi,et al.  Up-regulation of thrombospondin-1 gene by epidermal growth factor and transforming growth factor beta in human cancer cells--transcriptional activation and messenger RNA stabilization. , 2002, Biochimica et biophysica acta.

[11]  J. Kusiak,et al.  Nerve Growth Factor Uses Ras/ERK and Phosphatidylinositol 3-Kinase Cascades to Up-regulate theN-Methyl-d-aspartate Receptor 1 Promoter* , 2001, The Journal of Biological Chemistry.

[12]  H. Naganuma,et al.  Antisense‐mediated reduction in thrombospondin‐1 expression reduces cell motility in malignant glioma cells , 2001, International journal of cancer.

[13]  T. Liu,et al.  Suppression of matrix metalloproteinase-2 gene expression and invasion in human glioma cells by MMAC/PTEN , 2001, Oncogene.

[14]  Michael P. Myers,et al.  PTEN controls tumor-induced angiogenesis , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[15]  D. Roberts,et al.  Thrombospondin-1 Inhibits TCR-Mediated T Lymphocyte Early Activation , 2001, The Journal of Immunology.

[16]  C. Eng,et al.  Transient ectopic expression of PTEN in thyroid cancer cell lines induces cell cycle arrest and cell type-dependent cell death. , 2001, Human molecular genetics.

[17]  T. Terada,et al.  Protein expression of matrix metalloproteinases 2 and 9 and tissue inhibitors of metalloproteinase 1 and 2 in papillary thyroid carcinomas , 2001, Virchows Archiv.

[18]  H. Naganuma,et al.  Correlation of thrombospondin‐1 and transforming growth factor‐β expression with malignancy of glioma , 2000, Neuropathology : official journal of the Japanese Society of Neuropathology.

[19]  M. Iruela-Arispe,et al.  Cell Contact–dependent Activation of α3β1 Integrin Modulates Endothelial Cell Responses to Thrombospondin-1 , 2000 .

[20]  Z. Zhao,et al.  The Protein-tyrosine Phosphatase SHP-2 Is Required during Angiotensin II-mediated Activation of Cyclin D1 Promoter in CHO-AT1A Cells* , 2000, The Journal of Biological Chemistry.

[21]  O. Volpert,et al.  Smad4/DPC4-mediated tumor suppression through suppression of angiogenesis. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[22]  G. Tuszynski,et al.  Tumour cell thrombospondin-1 regulates tumour cell adhesion and invasion through the urokinase plasminogen activator receptor , 2000, British Journal of Cancer.

[23]  H. Namba,et al.  Inhibition of angiogenesis and tumorigenesis, and induction of dormancy by p53 in a p53-null thyroid carcinoma cell line in vivo. , 2000, Anticancer research.

[24]  V. Gahtan,et al.  Inhibition of phosphatidylinositol 3-kinase and protein kinase C attenuates extracellular matrix protein-induced vascular smooth muscle cell chemotaxis. , 2000, Journal of vascular surgery.

[25]  K. Brew,et al.  Tissue inhibitors of metalloproteinases: evolution, structure and function. , 2000, Biochimica et biophysica acta.

[26]  H. Krutzsch,et al.  Thrombospondin-1 promotes alpha3beta1 integrin-mediated adhesion and neurite-like outgrowth and inhibits proliferation of small cell lung carcinoma cells. , 2000, Cancer research.

[27]  L. Mariani,et al.  Expression of angiogenesis stimulators and inhibitors in human thyroid tumors and correlation with clinical pathological features. , 1999, The American journal of pathology.

[28]  L. Martiny,et al.  Immunohistochemical study of thrombospondin and its receptors alpha root of beta 3 and CD36 in normal thyroid and in thyroid tumours. , 1999, Journal of clinical pathology.

[29]  G. Mills,et al.  The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells , 1999, Oncogene.

[30]  S. Korem,et al.  Similar and divergent patterns in the regulation of matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of MMP-1 gene expression in benign and malignant human thyroid cells. , 1999, The Journal of clinical endocrinology and metabolism.

[31]  V. Gahtan,et al.  Thrombospondin-1 regulation of smooth muscle cell chemotaxis is extracellular signal-regulated protein kinases 1/2 dependent. , 1999, Surgery.

[32]  C. Schneider,et al.  Influence of transforming growth factor beta1 (TGF-beta1) on the behaviour of porcine thyroid epithelial cells in primary culture through thrombospondin-1 synthesis. , 1999, Journal of cell science.

[33]  L. Di Marcotullio,et al.  Thrombospondin-1 is a mediator of the neurotypic differentiation induced by EGF in thymic epithelial cells. , 1999, Experimental cell research.

[34]  M. Ittmann,et al.  Inactivation of the PTEN tumor suppressor gene is associated with increased angiogenesis in clinically localized prostate carcinoma. , 1999, Human pathology.

[35]  S. Al-Sedairy,et al.  Tissue inhibitor of metalloproteinases-1 (TIMP-1) mRNA is elevated in advanced stages of thyroid carcinoma , 1999, British Journal of Cancer.

[36]  Gordon Mills,et al.  Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC , 1998, Current Biology.

[37]  T. Yamamoto,et al.  Therapeutic usefulness of wild-type p53 gene introduction in a p53-null anaplastic thyroid carcinoma cell line. , 1998, The Journal of clinical endocrinology and metabolism.

[38]  Kenneth M. Yamada,et al.  Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN. , 1998, Science.

[39]  R. Hynes,et al.  Thrombospondin-1 is required for normal murine pulmonary homeostasis and its absence causes pneumonia. , 1998, The Journal of clinical investigation.

[40]  A. Theibert,et al.  Thrombospondin Signaling of Focal Adhesion Disassembly Requires Activation of Phosphoinositide 3-Kinase* , 1998, The Journal of Biological Chemistry.

[41]  C. ffrench-Constant,et al.  Expression and function of thrombospondin‐1 in myelinating glial cells of the central nervous system , 1997, Journal of neuroscience research.

[42]  W. Scherbaum,et al.  Human thyroid carcinoma cell lines and normal thyrocytes: expression and regulation of matrix metalloproteinase-1 and tissue matrix metalloproteinase inhibitor-1 messenger-RNA and protein. , 1997, Thyroid : official journal of the American Thyroid Association.

[43]  G. Tuszynski,et al.  Thrombospondin-1 modulates angiogenesis in vitro by up-regulation of matrix metalloproteinase-9 in endothelial cells. , 1997, Experimental cell research.

[44]  V. Dixit,et al.  Thrombospondin-1 suppresses tumorigenesis and angiogenesis in serum- and anchorage-independent NIH 3T3 cells. , 1997, Laboratory investigation; a journal of technical methods and pathology.

[45]  Jing Li,et al.  Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome , 1997, Nature Genetics.

[46]  T. Mikkelsen,et al.  Inhibition of angiogenesis in human glioblastomas by chromosome 10 induction of thrombospondin-1. , 1996, Cancer research.

[47]  M. Linial,et al.  Viral Myc Oncoproteins in Infected Fibroblasts Down-modulate Thrombospondin-1, a Possible Tumor Suppressor Gene* , 1996, The Journal of Biological Chemistry.

[48]  D. Roberts,et al.  Regulation of tumor growth and metastasis by thrombospondin‐1 , 1996, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[49]  M. Granick,et al.  Thrombospondin-1 (TSP-1) promotes the invasive properties of human breast cancer. , 1996, The Journal of surgical research.

[50]  P. Bornstein Diversity of function is inherent in matricellular proteins: an appraisal of thrombospondin 1 , 1995, The Journal of cell biology.

[51]  P. Bornstein,et al.  Transformation by v-src causes transient induction followed by repression of mouse thrombospondin-1. , 1994, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[52]  P. Steeg,et al.  Expression of the extracellular matrix molecule thrombospondin inversely correlates with malignant progression in melanoma, lung and breast carcinoma cell lines , 1994, International journal of cancer.

[53]  Y. DeClerck,et al.  Effect of tissue inhibitor of the matrix metalloproteinases-2 expression on the growth and spontaneous metastasis of a human melanoma cell line. , 1994, Cancer research.

[54]  K. Dameron,et al.  Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1. , 1994, Science.

[55]  P. Bornstein,et al.  Overlapping Egr-1 and Sp1 sites function in the regulation of transcription of the mouse thrombospondin 1 gene. , 1994, The Journal of biological chemistry.

[56]  Q. Duh,et al.  Epidermal growth factor enhances proliferation, migration, and invasion of follicular and papillary thyroid cancer in vitro and in vivo. , 1994, The Journal of clinical endocrinology and metabolism.

[57]  J. Barnwell,et al.  Analysis of CD36 binding domains: ligand specificity controlled by dephosphorylation of an ectodomain. , 1993, Science.

[58]  J. Lawler,et al.  Diverse mechanisms for cell attachment to platelet thrombospondin. , 1993, Journal of cell science.

[59]  P. Bornstein,et al.  A serum response element and a binding site for NF-Y mediate the serum response of the human thrombospondin 1 gene. , 1993, The Journal of biological chemistry.

[60]  W. Frazier,et al.  Identification of active peptide sequences in the carboxyl-terminal cell binding domain of human thrombospondin-1. , 1992, The Journal of biological chemistry.

[61]  C. Damsky,et al.  Invasion by cultured human follicular thyroid cancer correlates with increasedβ1 integrins and production of proteases , 1992, World Journal of Surgery.

[62]  P. Waterhouse,et al.  Suppression of invasion by inducible expression of tissue inhibitor of metalloproteinase-1 (TIMP-1) in B16-F10 melanoma cells. , 1992, Journal of the National Cancer Institute.

[63]  E. Prochownik,et al.  Antisense-mediated reduction in thrombospondin reverses the malignant phenotype of a human squamous carcinoma. , 1991, The Journal of clinical investigation.

[64]  L. Liotta,et al.  Platelet thrombospondin modulates endothelial cell adhesion, motility, and growth: a potential angiogenesis regulatory factor , 1990, The Journal of cell biology.

[65]  K. Harigaya,et al.  Tissue inhibitor of metalloproteinases from human bone marrow stromal cell line KM 102 has erythroid‐potentiating activity, suggesting its possibly bifunctional role in the hematopoietic microenvironment , 1990, FEBS letters.

[66]  B. Coulombe,et al.  Presence of transcription regulatory elements within an intron of the virus-inducible murine TIMP gene , 1988, Molecular and cellular biology.

[67]  V. Dixit,et al.  Cell surface thrombospondin is functionally essential for vascular smooth muscle cell proliferation , 1988, The Journal of cell biology.

[68]  G. Tuszynski,et al.  Thrombospondin, a potentiator of tumor cell metastasis. , 1987, Cancer research.

[69]  B. Coulombe,et al.  Characterization and expression of a murine gene homologous to human EPA/TIMP: a virus‐induced gene in the mouse. , 1987, The EMBO journal.

[70]  P. Bornstein,et al.  Control of smooth muscle cell growth by components of the extracellular matrix: autocrine role for thrombospondin. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[71]  K. Franssila,et al.  Hepatocyte growth factor receptor, matrix metalloproteinase-11, tissue inhibitor of metalloproteinase-1, and fibronectin are up-regulated in papillary thyroid carcinoma: a cDNA and tissue microarray study. , 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

[72]  J. Adams,et al.  Thrombospondins: multifunctional regulators of cell interactions. , 2001, Annual review of cell and developmental biology.

[73]  O. Volpert,et al.  Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1 , 2000, Nature Medicine.

[74]  C. Bucana,et al.  Level and function of epidermal growth factor receptor predict the metastatic potential of human colon carcinoma cells. , 1995, Clinical cancer research : an official journal of the American Association for Cancer Research.

[75]  Z. Darżynkiewicz,et al.  Features of apoptotic cells measured by flow cytometry. , 1992, Cytometry.