The phenytoin metabolite p-HPPH upregulates prostaglandin biosynthesis in human gingival fibroblasts challenged to interleukin-1.

[1]  U. Lerner,et al.  Enhanced prostaglandin biosynthesis in human gingival fibroblasts isolated from patients treated with phenytoin. , 1992, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[2]  U. Lerner,et al.  Phenytoin potentiates interleukin‐1‐induced prostaglandin biosynthesis in human gingival fibroblasts , 1992, British journal of pharmacology.

[3]  A. Fine,et al.  Discordant regulation of human type I collagen genes by prostaglandin E2. , 1992, Biochimica et biophysica acta.

[4]  P. Berggren,et al.  Influence of phenytoin on cytoplasmic free Ca2+ level in human gingival fibroblasts. , 1991, Scandinavian journal of dental research.

[5]  F. Dewhirst,et al.  Comparison of human interleukin-1 beta and its 163-171 peptide in bone resorption and the immune response. , 1991, Cytokine.

[6]  T. Salo,et al.  Effect of phenytoin and nifedipine on collagen gene expression in human gingival fibroblasts. , 1990, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[7]  T. Modéer,et al.  Effect of phenytoin on intracellular 45Ca2+ accumulation in gingival fibroblasts in vitro. , 1989, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[8]  J. Karlinsky,et al.  Regulation of sulfated glycosaminoglycan production by prostaglandin E2 in cultured lung fibroblasts. , 1989, The Journal of laboratory and clinical medicine.

[9]  K. Matsushima,et al.  Interleukin 1 stimulates its own receptor expression on human fibroblasts through the endogenous production of prostaglandin(s). , 1988, The Journal of clinical investigation.

[10]  P. Bartold.  The effect of interleukin-1 beta on hyaluronic acid synthesized by adult human gingival fibroblasts in vitro. , 1988, Journal of periodontal research.

[11]  C. Dinarello,et al.  Biology of interleukin 1 , 1988, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[12]  R. Rutherford,et al.  The effects of interleukin 1 on collagenolytic activity and prostaglandin-E secretion by human periodontal-ligament and gingival fibroblast. , 1988, Archives of oral biology.

[13]  P. Bartold.  The effect of interleukin 1 beta on proteoglycans synthesized by human gingival fibroblasts in vitro. , 1988, Connective tissue research.

[14]  N. Schwartz,et al.  The effects of phenytoin (5,5-diphenylhydantoin) on human gingival fibroblasts in culture. , 1987, Journal of periodontal research.

[15]  A. Hjerpe,et al.  Synthesis of sulfated glycosaminoglycans by human gingival fibroblasts from phenytoin-induced gingival overgrowth in vitro. , 1987, Scandinavian journal of dental research.

[16]  I. Roots,et al.  Stereochemistry of aromatic phenytoin hydroxylation in various drug hydroxylation phenotypes in humans. , 1987, The Journal of pharmacology and experimental therapeutics.

[17]  P. Boonekamp,et al.  Stimulation of bone resorption in cultured mouse calvaria by Lys-bradykinin (kallidin), a potential mediator of bone resorption linking anaphylaxis processes to rarefying osteitis. , 1986, Bone and mineral.

[18]  K. Theorell,et al.  Oral health in non-institutionalized epileptic children with special reference to phenytoin medication. , 1986, Community dentistry and oral epidemiology.

[19]  G. Mundy,et al.  Actions of recombinant interleukin 1, interleukin 2, and interferon-gamma on bone resorption in vitro. , 1986, Journal of immunology.

[20]  F. Reinholt,et al.  Proteoglycans and glycosaminoglycans in phenytoin-induced gingival overgrowth. , 1986, Journal of periodontal research.

[21]  F. Reinholt,et al.  A quantitative analysis of connective tissue components in phenytoin-induced gingival overgrowth in children. A stereological study. , 1984, Journal of periodontal research.

[22]  T. Hassell,et al.  Phenytoin sensitivity of fibroblasts as the basis for susceptibility to gingival enlargement. , 1983, The American journal of pathology.

[23]  M. Kantor,et al.  Increased Accumulation of Sulfated Glycosaminoglycans in Cultures of Human Fibroblasts from Phenytoin-induced Gingival Overgrowth , 1983 .

[24]  T. Hassell,et al.  Evidence for production of an inactive collagenase by fibroblasts from phenytoin-enlarged human gingivae. , 1982, Journal of oral pathology.

[25]  T. Modéer,et al.  The effect of the phenytoin metabolite p-HPPH on proliferation of gingival fibroblasts in vitro. , 1982, Acta odontologica Scandinavica.

[26]  T. Hassell.  Epilepsy and the oral manifestations of phenytoin therapy. , 1981, Monographs in oral science.

[27]  M. C. Johnston,et al.  Phenytoin-induced teratology and gingival pathology , 1980 .

[28]  R. Page,et al.  The major metabolite of phenytoin (Dilantin) induces gingival overgrowth in cats. , 1978, Journal of periodontal research.

[29]  A. Fine,et al.  BASIC BIOLOGICAL SCIENCES Confirmation that Neither Phenotype Nor Hydroxylation of Collagen Is Altered In Overgrown Gingiva From Diphenylhydantoin-Treated Patients , 1978, Journal of dental research.

[30]  P. Axelsson,et al.  Effect of fluoride on gingivitis and dental caries in a preventive program based on plaque control. , 1975, Community dentistry and oral epidemiology.

[31]  E. Reynolds.  Chronic Antiepileptic Toxicity: A Review , 1975, Epilepsia.

[32]  G. J. Conard,et al.  Levels of 5,5-Diphenylhydantoin and its Major Metabolite in Human Serum, Saliva, and Hyperplastic Gingiva , 1974, Journal of dental research.

[33]  K. Nuki,et al.  The role of inflammation in the pathogenesis of gingival enlargement during the administration of diphenylhydantoin sodium in cats. , 1972, Journal of periodontal research.

[34]  T. Butler.  The metabolic conversion of 5, 5-diphenyl hydantoin to 5-(p-hydroxyphenyl)-5-phenyl hydantoin. , 1957, The Journal of pharmacology and experimental therapeutics.