Gender differences in the association of red cell distribution width and coronary artery disease

Objective: Red cell distribution width (RDW) is independently associated with morbidity and mortality in cardiovascular diseases. The aim of the present study was to explore the gender difference of RDW in patients with coronary artery disease (CAD). Methods: A total of 674 consecutively hospitalized individuals who received coronary angiography (CAG) were enrolled and divided into two groups: a CAD group (n = 499) and a control group (n = 175). Their baseline clinical characteristics were collected, and the gender differences of RDW in predicting the presence of CAD were assessed. Results: RDW in female patients with CAD was significantly higher than in those without CAD. In contrast, no significant difference in RDW between male individuals with and without CAD was found. Multivariate logistic regression analysis showed that age and RDW were independent predictors for CAD in females. Receiver operating characteristic (ROC) curve analysis indicated that a RDW value of 12.75% was an effective cut-off point in the segregation of the presence or absence of CAD with a sensitivity of 57.1% and a specificity of 66.3%. Conclusion: The present study shows a significant association between RDW levels and female CAD across gender strata, suggesting that elevated RDW may be an independent predictor of CAD in women.

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