A Paradigm Shift in Functional Brain Imaging

### Introduction The history of brain imaging has paralleled the growth of the Society for Neuroscience, from its inception in 1973 with the introduction of x-ray computed tomography (CT) to the present (for a historical review, see [Webb, 1990][1]; [Kevles, 1997][2]; [Raichle, 2000][3]; [Raichle,

[1]  A. Grinvald,et al.  Interaction of sensory responses with spontaneous depolarization in layer 2/3 barrel cortex , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[2]  P. Magistretti,et al.  Glutamate Uptake Stimulates Na+,K+‐ATPase Activity in Astrocytes via Activation of a Distinct Subunit Highly Sensitive to Ouabain , 1997, Journal of neurochemistry.

[3]  F. Mayor Memory of the future , 1995 .

[4]  Jeffrey M. Zacks,et al.  Coherent spontaneous activity accounts for trial-to-trial variability in human evoked brain responses , 2006, Nature Neuroscience.

[5]  Nr Sibson,et al.  In vivo ^ C NMR measurements of cerebral synthesis as evidence for glutamate-glutamine cycling , 1997 .

[6]  Viktor K. Jirsa,et al.  Noise during Rest Enables the Exploration of the Brain's Dynamic Repertoire , 2008, PLoS Comput. Biol..

[7]  W. Singer,et al.  Frontiers in Integrative Neuroscience Integrative Neuroscience Neural Synchrony in Cortical Networks: History, Concept and Current Status , 2022 .

[8]  Yevgeniy B. Sirotin,et al.  Anticipatory haemodynamic signals in sensory cortex not predicted by local neuronal activity. , 2009, Nature.

[9]  Louis Sokoloff,et al.  Circulation and Energy Metabolism of the Brain , 1999 .

[10]  M. Fox,et al.  Intrinsic functional relations between human cerebral cortex and thalamus. , 2008, Journal of neurophysiology.

[11]  M. Corbetta,et al.  Common Blood Flow Changes across Visual Tasks: II. Decreases in Cerebral Cortex , 1997, Journal of Cognitive Neuroscience.

[12]  L S Hibbard,et al.  GABAergic Neurons in Barrel Cortex Show Strong, Whisker-Dependent Metabolic Activation during Normal Behavior , 1997, The Journal of Neuroscience.

[13]  M. Fox,et al.  Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging , 2007, Nature Reviews Neuroscience.

[14]  James R Laguardia,et al.  Slow oscillations of cytochrome oxidase redox state and blood volume in unanesthetized cat and rabbit cortex. Interhemispheric synchrony. , 1998, Advances in experimental medicine and biology.

[15]  R. Woodworth,et al.  The Integrative Action of the Nervous System , 1908 .

[16]  Abraham Z. Snyder,et al.  A default mode of brain function: A brief history of an evolving idea , 2007, NeuroImage.

[17]  Justin L. Vincent,et al.  Intrinsic Fluctuations within Cortical Systems Account for Intertrial Variability in Human Behavior , 2007, Neuron.

[18]  Biyu J. He,et al.  The fMRI signal, slow cortical potential and consciousness , 2009, Trends in Cognitive Sciences.

[19]  M. Weliky,et al.  Small modulation of ongoing cortical dynamics by sensory input during natural vision , 2004, Nature.

[20]  Stephen M Smith,et al.  Correspondence of the brain's functional architecture during activation and rest , 2009, Proceedings of the National Academy of Sciences.

[21]  Clara A. Scholl,et al.  Synchronized delta oscillations correlate with the resting-state functional MRI signal , 2007, Proceedings of the National Academy of Sciences.

[22]  L. Sokoloff,et al.  The effect of mental arithmetic on cerebral circulation and metabolism. , 1955, The Journal of clinical investigation.

[23]  G L Shulman,et al.  INAUGURAL ARTICLE by a Recently Elected Academy Member:A default mode of brain function , 2001 .

[24]  S. Laughlin,et al.  An Energy Budget for Signaling in the Grey Matter of the Brain , 2001, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[25]  Misha Tsodyks,et al.  The Emergence of Up and Down States in Cortical Networks , 2006, PLoS Comput. Biol..

[26]  Moshe Bar,et al.  The proactive brain: memory for predictions , 2009, Philosophical Transactions of the Royal Society B: Biological Sciences.

[27]  J. Palva,et al.  Infraslow oscillations modulate excitability and interictal epileptic activity in the human cortex during sleep. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[28]  A. Grinvald,et al.  Dynamics of Ongoing Activity: Explanation of the Large Variability in Evoked Cortical Responses , 1996, Science.

[29]  R. Yuste,et al.  Introduction: spontaneous activity in the developing central nervous system. , 1997, Seminars in cell & developmental biology.

[30]  宁北芳,et al.  疟原虫var基因转换速率变化导致抗原变异[英]/Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A , 2005 .

[31]  P. Lennie The Cost of Cortical Computation , 2003, Current Biology.

[32]  Pierre J Magistretti,et al.  GABA uptake into astrocytes is not associated with significant metabolic cost: Implications for brain imaging of inhibitory transmission , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[33]  Ravi S. Menon,et al.  Intrinsic signal changes accompanying sensory stimulation: functional brain mapping with magnetic resonance imaging. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[34]  M. Feller,et al.  Mechanisms underlying development of visual maps and receptive fields. , 2008, Annual review of neuroscience.

[35]  K. Christoff,et al.  Experience sampling during fMRI reveals default network and executive system contributions to mind wandering , 2009, Proceedings of the National Academy of Sciences.

[36]  Justin L. Vincent,et al.  Intrinsic functional architecture in the anaesthetized monkey brain , 2007, Nature.

[37]  Fahmeed Hyder,et al.  Energetic basis of brain activity: implications for neuroimaging , 2004, Trends in Neurosciences.

[38]  J. A. Frost,et al.  Conceptual Processing during the Conscious Resting State: A Functional MRI Study , 1999, Journal of Cognitive Neuroscience.

[39]  G. Karmos,et al.  Entrainment of Neuronal Oscillations as a Mechanism of Attentional Selection , 2008, Science.

[40]  M. Steriade,et al.  A novel slow (< 1 Hz) oscillation of neocortical neurons in vivo: depolarizing and hyperpolarizing components , 1993, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[41]  R. Shulman,et al.  Stoichiometric coupling of brain glucose metabolism and glutamatergic neuronal activity. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[42]  O. Sporns,et al.  Complex brain networks: graph theoretical analysis of structural and functional systems , 2009, Nature Reviews Neuroscience.

[43]  T. Brown On the nature of the fundamental activity of the nervous centres; together with an analysis of the conditioning of rhythmic activity in progression, and a theory of the evolution of function in the nervous system , 1914, The Journal of physiology.

[44]  D. Ingvar "Memory of the future": an essay on the temporal organization of conscious awareness. , 1985, Human neurobiology.

[45]  M. Mintun,et al.  Brain work and brain imaging. , 2006, Annual review of neuroscience.

[46]  R. Turner,et al.  Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[47]  R. Shulman,et al.  The contribution of GABA to glutamate/glutamine cycling and energy metabolism in the rat cortex in vivo. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[48]  N. Logothetis,et al.  Phase-of-Firing Coding of Natural Visual Stimuli in Primary Visual Cortex , 2008, Current Biology.

[49]  G. Buzsáki,et al.  Neuronal Oscillations in Cortical Networks , 2004, Science.

[50]  D. DiSantis,et al.  Naked to the Bone: Medical Imaging in the Twentieth Century , 1998 .

[51]  D. Leopold Neuroscience: Pre-emptive blood flow , 2009, Nature.

[52]  B. Mazoyer,et al.  Cortical networks for working memory and executive functions sustain the conscious resting state in man , 2001, Brain Research Bulletin.

[53]  P. Fransson How default is the default mode of brain function? Further evidence from intrinsic BOLD signal fluctuations , 2006, Neuropsychologia.

[54]  M. Hallett,et al.  The relative metabolic demand of inhibition and excitation , 2000, Nature.

[55]  N. A. Lassen,et al.  Brain work. The coupling of function, metabolism and blood flow in the brain. , 1975 .

[56]  Adelbert Ames,et al.  CNS energy metabolism as related to function , 2000, Brain Research Reviews.

[57]  W. Smith The Integrative Action of the Nervous System , 1907, Nature.

[58]  M. Raichle A brief history of human brain mapping , 2009, Trends in Neurosciences.

[59]  J. Frahm,et al.  Dynamic MR imaging of human brain oxygenation during rest and photic stimulation , 1992, Journal of magnetic resonance imaging : JMRI.

[60]  M. Raichle A Brief History of Human Functional Brain Mapping , 2000 .

[61]  S. Petersen,et al.  The maturing architecture of the brain's default network , 2008, Proceedings of the National Academy of Sciences.

[62]  G. Buzsáki,et al.  Inhibition and Brain Work , 2007, Neuron.

[63]  J. Chatton,et al.  Relationship between L-glutamate-regulated intracellular Na+ dynamics and ATP hydrolysis in astrocytes , 2004, Journal of Neural Transmission.

[64]  D. Schacter,et al.  The Brain's Default Network , 2008, Annals of the New York Academy of Sciences.

[65]  R G Shulman,et al.  In vivo 13C NMR measurements of cerebral glutamine synthesis as evidence for glutamate-glutamine cycling. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[66]  T. Kuhn,et al.  The Structure of Scientific Revolutions. , 1964 .

[67]  M. Wong-Riley Cytochrome oxidase: an endogenous metabolic marker for neuronal activity , 1989, Trends in Neurosciences.

[68]  N. Logothetis What we can do and what we cannot do with fMRI , 2008, Nature.

[69]  P. Fries Neuronal gamma-band synchronization as a fundamental process in cortical computation. , 2009, Annual review of neuroscience.

[70]  T L Babb,et al.  Increased glucose metabolism during long-duration recurrent inhibition of hippocampal pyramidal cells , 1984, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[71]  M. Raichle,et al.  Cortical network functional connectivity in the descent to sleep , 2009, Proceedings of the National Academy of Sciences.

[72]  R. S. Hinks,et al.  Time course EPI of human brain function during task activation , 1992, Magnetic resonance in medicine.

[73]  Maurizio Corbetta,et al.  The human brain is intrinsically organized into dynamic, anticorrelated functional networks. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[74]  I. Fried,et al.  Interhemispheric correlations of slow spontaneous neuronal fluctuations revealed in human sensory cortex , 2008, Nature Neuroscience.

[75]  M. Fox,et al.  The global signal and observed anticorrelated resting state brain networks. , 2009, Journal of neurophysiology.

[76]  J. Palva,et al.  Very Slow EEG Fluctuations Predict the Dynamics of Stimulus Detection and Oscillation Amplitudes in Humans , 2008, The Journal of Neuroscience.

[77]  Brigitte Röder,et al.  On the relationship between slow cortical potentials and BOLD signal changes in humans. , 2008, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[78]  Biyu J. He,et al.  Electrophysiological correlates of the brain's intrinsic large-scale functional architecture , 2008, Proceedings of the National Academy of Sciences.

[79]  D. Paré,et al.  Contrasting Activity Profile of Two Distributed Cortical Networks as a Function of Attentional Demands , 2009, The Journal of Neuroscience.

[80]  Vinod Menon,et al.  Functional connectivity in the resting brain: A network analysis of the default mode hypothesis , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[81]  A. Lansner,et al.  The cortex as a central pattern generator , 2005, Nature Reviews Neuroscience.

[82]  Entrainment of Slow Oscillations of Auditory Thalamic Neurons by Repetitive Sound Stimuli , 2009, The Journal of Neuroscience.

[83]  M. Greicius,et al.  Persistent default‐mode network connectivity during light sedation , 2008, Human brain mapping.

[84]  B. Rockstroh Slow cortical potentials and behavior , 1989 .

[85]  E. Marder,et al.  Variability, compensation and homeostasis in neuron and network function , 2006, Nature Reviews Neuroscience.

[86]  S. Kety,et al.  The circulation and energy metabolism of the brain. , 1963, Clinical neurosurgery.

[87]  C. Schroeder,et al.  Low-frequency neuronal oscillations as instruments of sensory selection , 2009, Trends in Neurosciences.

[88]  O. Sporns,et al.  Mapping the Structural Core of Human Cerebral Cortex , 2008, PLoS biology.

[89]  M. Corbetta,et al.  Top-Down Control of Human Visual Cortex by Frontal and Parietal Cortex in Anticipatory Visual Spatial Attention , 2008, The Journal of Neuroscience.

[90]  B. Biswal,et al.  Functional connectivity in the motor cortex of resting human brain using echo‐planar mri , 1995, Magnetic resonance in medicine.

[91]  R G Shulman,et al.  Cerebral energetics and the glycogen shunt: Neurochemical basis of functional imaging , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[92]  Rafael Yuste,et al.  UP States Protect Ongoing Cortical Activity from Thalamic Inputs , 2008, PloS one.

[93]  M. Fox,et al.  Noninvasive functional and structural connectivity mapping of the human thalamocortical system. , 2010, Cerebral cortex.

[94]  J. Martinerie,et al.  The brainweb: Phase synchronization and large-scale integration , 2001, Nature Reviews Neuroscience.

[95]  Roel H. R. Deckers,et al.  Large-amplitude, spatially correlated fluctuations in BOLD fMRI signals during extended rest and early sleep stages. , 2006, Magnetic resonance imaging.