An indolocarbazole inhibitor of human checkpoint kinase (Chk1) abrogates cell cycle arrest caused by DNA damage.
暂无分享,去创建一个
J. Jackson | A. Gilmartin | C. Imburgia | J. Winkler | L. Marshall | A. Roshak | L A Marshall | J R Jackson | A Gilmartin | C Imburgia | J D Winkler | A Roshak | J. Winkler
[1] A. Eastman,et al. Enhancement of cisplatin-induced cytotoxicity by 7-hydroxystaurosporine (UCN-01), a new G2-checkpoint inhibitor. , 1996, Clinical cancer research : an official journal of the American Association for Cancer Research.
[2] K. Kohn,et al. Abrogation of an S-phase checkpoint and potentiation of camptothecin cytotoxicity by 7-hydroxystaurosporine (UCN-01) in human cancer cell lines, possibly influenced by p53 function. , 1997, Cancer research.
[3] H. Piwnica-Worms,et al. A human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damage. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[4] I. Takahashi,et al. UCN-01, a selective inhibitor of protein kinase C from Streptomyces. , 1987, The Journal of antibiotics.
[5] I. Christensen,et al. A detergent-trypsin method for the preparation of nuclei for flow cytometric DNA analysis. , 1983, Cytometry.
[6] B. Vogelstein,et al. Participation of p53 protein in the cellular response to DNA damage. , 1991, Cancer research.
[7] P. O'Connor,et al. DNA damage checkpoints: implications for cancer therapy. , 1996, Progress in cell cycle research.
[8] C. Peng,et al. Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216. , 1997, Science.
[9] L. Meijer. Chemical inhibitors of cyclin-dependent kinases. , 1996, Trends in cell biology.
[10] S. Antoku,et al. Enhancement of X-ray cell killing in cultured mammalian cells by the protein phosphatase inhibitor calyculin A. , 1994, Cancer research.
[11] D. Vesey,et al. Inhibitors of protein kinase C. 3. Potent and highly selective bisindolylmaleimides by conformational restriction. , 1993, Journal of medicinal chemistry.
[12] P. Kirschmeier,et al. Indolocarbazoles. 1. Total synthesis and protein kinase inhibiting characteristics of compounds related to K-252c. , 1993 .
[13] D. Scudiero,et al. Evaluation of a soluble tetrazolium/formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines. , 1988, Cancer research.
[14] F Ianzini,et al. Spontaneous premature chromosome condensation and mitotic catastrophe following irradiation of HeLa S3 cells. , 1997, International journal of radiation biology.
[15] A. Fattaey,et al. Myt1: a Wee1-type kinase that phosphorylates Cdc2 on residue Thr14. , 1997, Progress in cell cycle research.
[16] E. Sausville,et al. UCN-01: a potent abrogator of G2 checkpoint function in cancer cells with disrupted p53. , 1996, Journal of the National Cancer Institute.
[17] A. Blasina,et al. A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase , 1999, Current Biology.
[18] R. Schlegel,et al. Staurosporine overrides checkpoints for mitotic onset in BHK cells. , 1992, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.
[19] C. Peng,et al. C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding. , 1998, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.
[20] A. Pardee,et al. Mechanism by which caffeine potentiates lethality of nitrogen mustard. , 1982, Proceedings of the National Academy of Sciences of the United States of America.
[21] Antony M. Carr,et al. The chk1 pathway is required to prevent mitosis following cell-cycle arrest at ‘start’ , 1995, Current Biology.
[22] M. Groudine,et al. Abrogation of the G2 checkpoint results in differential radiosensitization of G1 checkpoint-deficient and G1 checkpoint-competent cells. , 1995, Cancer research.
[23] A. Kumagai,et al. The Xenopus Chk1 Protein Kinase Mediates a Caffeine-sensitive Pathway of Checkpoint Control in Cell-free Extracts , 1998, The Journal of cell biology.
[24] J. Boehm,et al. Synthesis of water-soluble (aminoalkyl)camptothecin analogs: inhibition of topoisomerase I and antitumor activity , 1991 .
[25] J. Bishop,et al. Ro 32-0432, a selective and orally active inhibitor of protein kinase C prevents T-cell activation. , 1994, The Journal of pharmacology and experimental therapeutics.
[26] N. Walworth,et al. Association of Chk1 with 14-3-3 proteins is stimulated by DNA damage. , 1999, Genes & development.
[27] S. Elledge,et al. Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25. , 1997, Science.
[28] M. Yoshida,et al. Highly synchronous culture of fibroblasts from G2 block caused by staurosporine, a potent inhibitor of protein kinases. , 1991, Experimental cell research.
[29] W. Dewey,et al. Nuclear fragmentation and premature chromosome condensation induced by heat shock in S-phase Chinese hamster ovary cells. , 1988, Cancer research.
[30] M. Hemling,et al. Protein kinase C inhibitors: novel spirosesquiterpene aldehydes from a marine sponge Aka (= Siphonodictyon) coralliphagum. , 1994, Journal of natural products.
[31] R. Muschel,et al. The molecular basis for cell cycle delays following ionizing radiation: a review. , 1994, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.
[32] S. Akinaga,et al. Enhancement of antitumor activity of mitomycin C in vitro and in vivo by UCN-01, a selective inhibitor of protein kinase C , 2004, Cancer Chemotherapy and Pharmacology.
[33] A. Eastman,et al. The role of cell cycle progression in cisplatin-induced apoptosis in Chinese hamster ovary cells. , 1994, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.
[34] Scott Davey,et al. Fission yeast chkl protein kinase links the rad checkpoint pathway to cdc2 , 1993, Nature.
[35] A. Carr. Checkpoints Take the Next Step , 1996, Science.
[36] O'Connor Pm. Mammalian G1 and G2 phase checkpoints. , 1997 .
[37] S. Elledge,et al. Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. , 1998, Science.
[38] J. Boehm,et al. Synthesis of water-soluble (aminoalkyl)camptothecin analogues: inhibition of topoisomerase I and antitumor activity. , 1991, Journal of medicinal chemistry.
[39] S. Haggarty,et al. High-throughput assay for G2 checkpoint inhibitors and identification of the structurally novel compound isogranulatimide. , 1998, Cancer research.
[40] S. Carr,et al. Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway , 1999, Oncogene.
[41] P. O'Connor. Mammalian G1 and G2 phase checkpoints. , 1997, Cancer surveys.
[42] P. Russell,et al. Replication checkpoint enforced by kinases Cds1 and Chk1. , 1998, Science.
[43] I. Radford,et al. Explaining differences in sensitivity to killing by ionizing radiation between human lymphoid cell lines. , 1998, Cancer research.