Protein functions in pre-mRNA splicing.

[1]  J. Lauber,et al.  An evolutionarily conserved U5 snRNP‐specific protein is a GTP‐binding factor closely related to the ribosomal translocase EF‐2 , 1997, The EMBO journal.

[2]  J. Lauber,et al.  The [U4/U6.U5] tri-snRNP-specific 27K protein is a novel SR protein that can be phosphorylated by the snRNP-associated protein kinase. , 1997, RNA.

[3]  A. Klingenhoff,et al.  Functional analysis of the fission yeast Prp4 protein kinase involved in pre-mRNA splicing and isolation of a putative mammalian homologue. , 1997, Nucleic acids research.

[4]  J. Manley,et al.  Phosphorylation of the ASF/SF2 RS domain affects both protein-protein and protein-RNA interactions and is necessary for splicing. , 1997, Genes & development.

[5]  M. Mann,et al.  Identification of the proteins of the yeast U1 small nuclear ribonucleoprotein complex by mass spectrometry. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[6]  P. Sharp,et al.  SC35-mediated reconstitution of splicing in U2AF-depleted nuclear extract. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[7]  A. Krainer,et al.  A human protein required for the second step of pre-mRNA splicing is functionally related to a yeast splicing factor. , 1997, Genes & development.

[8]  J. Abelson,et al.  The Saccharomyces cerevisiae Prp5 Protein Has RNA-dependent ATPase Activity with Specificity for U2 Small Nuclear RNA* , 1996, The Journal of Biological Chemistry.

[9]  R. Lührmann,et al.  Molecular cloning and subcellular localisation of the snRNP-associated protein 69KD, a structural homologue of the proto-oncoproteins TLS and EWS with RNA and DNA-binding properties. , 1996, Journal of molecular biology.

[10]  R. Lin,et al.  Spliceosome activation by PRP2 ATPase prior to the first transesterification reaction of pre-mRNA splicing , 1996, Molecular and cellular biology.

[11]  C. Will,et al.  In vitro reconstitution of mammalian U1 snRNPs active in splicing: the U1-C protein enhances the formation of early (E) spliceosomal complexes. , 1996, Nucleic acids research.

[12]  A. Krainer,et al.  U1-Mediated Exon Definition Interactions Between AT-AC and GT-AG Introns , 1996, Science.

[13]  B. Chabot.  Directing alternative splicing: cast and scenarios. , 1996, Trends in genetics : TIG.

[14]  M. Rosbash,et al.  Characterization of yeast U1 snRNP A protein: identification of the N-terminal RNA binding domain (RBD) binding site and evidence that the C-terminal RBD functions in splicing. , 1996, RNA.

[15]  Jane Y. Wu,et al.  Functional properties of p54, a novel SR protein active in constitutive and alternative splicing , 1996, Molecular and cellular biology.

[16]  J. Tazi,et al.  Involvement of U1 Small Nuclear Ribonucleoproteins (snRNP) in 5′ Splice Site-U1 snRNP Interaction* , 1996, The Journal of Biological Chemistry.

[17]  Woan-Yuh Tarn,et al.  Highly Diverged U4 and U6 Small Nuclear RNAs Required for Splicing Rare AT-AC Introns , 1996, Science.

[18]  Michael R. Green,et al.  Interaction of U2AF65 RS Region with Pre-mRNA of Branch Point and Promotion Base Pairing with U2 snRNA , 1996, Science.

[19]  D. Görlich,et al.  A yeast cap binding protein complex (yCBC) acts at an early step in pre-mRNA splicing. , 1996, Nucleic acids research.

[20]  R. O’Keefe,et al.  The Invariant U5 snRNA Loop 1 Sequence Is Dispensable for the First Catalytic Step of pre-mRNA Splicing in Yeast , 1996, Cell.

[21]  P. Sharp,et al.  A hyperphosphorylated form of the large subunit of RNA polymerase II is associated with splicing complexes and the nuclear matrix. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[22]  J. Rossi,et al.  Identification and characterization of yeast mutants that overcome an experimentally introduced block to splicing at the 3' splice site. , 1996, RNA.

[23]  J. Lauber,et al.  The HeLa 200 kDa U5 snRNP‐specific protein and its homologue in Saccharomyces cerevisiae are members of the DEXH‐box protein family of putative RNA helicases. , 1996, The EMBO journal.

[24]  A. Krämer,et al.  Mammalian splicing factor SF1 is encoded by variant cDNAs and binds to RNA. , 1996, RNA.

[25]  A. Yuryev,et al.  The C-terminal domain of the largest subunit of RNA polymerase II interacts with a novel set of serine/arginine-rich proteins. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[26]  M. Rosbash,et al.  The yeast splicing factor Mud13p is a commitment complex component and corresponds to CBP20, the small subunit of the nuclear cap-binding complex. , 1996, Genes & development.

[27]  J. Manley,et al.  SR proteins and splicing control. , 1996, Genes & development.

[28]  B. Schwer,et al.  Requirement for SLU7 in yeast pre-mRNA splicing is dictated by the distance between the branchpoint and the 3' splice site. , 1996, RNA.

[29]  C. McGuigan,et al.  A nuclear cap-binding complex facilitates association of U1 snRNP with the cap-proximal 5' splice site. , 1996, Genes & development.

[30]  R. Reed,et al.  Identification of proteins that interact with exon sequences, splice sites, and the branchpoint sequence during each stage of spliceosome assembly , 1996, Molecular and cellular biology.

[31]  J. Friesen,et al.  An RNA-dependent ATPase associated with U2/U6 snRNAs in pre-mRNA splicing , 1996, Nature.

[32]  T. Maniatis,et al.  The splicing factor U2AF35 mediates critical protein-protein interactions in constitutive and enhancer-dependent splicing. , 1996, Genes & development.

[33]  S. Shuman,et al.  Conditional inactivation of mRNA capping enzyme affects yeast pre-mRNA splicing in vivo. , 1996, RNA.

[34]  S. Buratowski,et al.  Conditional mutants of the yeast mRNA capping enzyme show that the cap enhances, but is not required for, mRNA splicing. , 1996, RNA.

[35]  C. Guthrie,et al.  Mutagenesis of the yeast gene PRP8 reveals domains governing the specificity and fidelity of 3' splice site selection. , 1996, Genetics.

[36]  J. Tazi,et al.  Specific phosphorylation of SR proteins by mammalian DNA topoisomerase I , 1996, Nature.

[37]  C. Guthrie,et al.  Identification of novel genes required for yeast pre-mRNA splicing by means of cold-sensitive mutations. , 1996, Genetics.

[38]  Y. Shimura,et al.  A human RNA helicase-like protein, HRH1, facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome. , 1996, Genes & development.

[39]  R. Reed,et al.  Initial splice-site recognition and pairing during pre-mRNA splicing. , 1996, Current opinion in genetics & development.

[40]  R. Padgett,et al.  Requirement of U12 snRNA for in Vivo Splicing of a Minor Class of Eukaryotic Nuclear Pre-mRNA Introns , 1996, Science.

[41]  Woan-Yuh Tarn,et al.  A Novel Spliceosome Containing U11, U12, and U5 snRNPs Excises a Minor Class (AT–AC) Intron In Vitro , 1996, Cell.

[42]  H. Kao,et al.  Identification of Prp40, a novel essential yeast splicing factor associated with the U1 small nuclear ribonucleoprotein particle , 1996, Molecular and Cellular Biology.

[43]  J. Reyes,et al.  The canonical GU dinucleotide at the 5' splice site is recognized by p220 of the U5 snRNP within the spliceosome. , 1996, RNA.

[44]  R. Reed,et al.  Evidence that sequence-independent binding of highly conserved U2 snRNP proteins upstream of the branch site is required for assembly of spliceosomal complex A. , 1996, Genes & development.

[45]  M. Ares,et al.  CUS1, a suppressor of cold-sensitive U2 snRNA mutations, is a novel yeast splicing factor homologous to human SAP 145. , 1996, Genes & development.

[46]  T Pawson,et al.  The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution. , 1996, The EMBO journal.

[47]  J. Lauber,et al.  Identification of an RNA-dependent ATPase activity in mammalian U5 snRNPs. , 1996, Nucleic acids research.

[48]  A. Krämer,et al.  The structure and function of proteins involved in mammalian pre-mRNA splicing. , 1996, Annual review of biochemistry.

[49]  C. Guthrie,et al.  The second catalytic step of pre-mRNA splicing. , 1995, RNA.

[50]  Xiang-Dong Fu,et al.  The superfamily of arginine/serine-rich splicing factors. , 1995, RNA.

[51]  M. Garcia-Blanco,et al.  SR proteins escort the U4/U6.U5 tri-snRNP to the spliceosome. , 1995, RNA.

[52]  C. Guthrie,et al.  Prp16p, Slu7p, and Prp8p interact with the 3' splice site in two distinct stages during the second catalytic step of pre-mRNA splicing. , 1995, RNA.

[53]  T. Nilsen.  trans-splicing: an update. , 1995, Molecular and biochemical parasitology.

[54]  A. Krämer,et al.  Mammalian splicing factor SF3a120 represents a new member of the SURP family of proteins and is homologous to the essential splicing factor PRP21p of Saccharomyces cerevisiae. , 1995, RNA.

[55]  C. Guthrie,et al.  A novel role for a U5 snRNP protein in 3' splice site selection. , 1995, Genes & development.

[56]  J. Steitz,et al.  Modulation of 5' splice site choice in pre-messenger RNA by two distinct steps. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[57]  A. Lamond,et al.  Pre-mRNA Processing , 1995, Molecular Biology Intelligence Unit.

[58]  S. Berget.  Exon Recognition in Vertebrate Splicing (*) , 1995, The Journal of Biological Chemistry.

[59]  J. Beggs,et al.  The role of PRP8 protein in nuclear pre-mRNA splicing in yeast , 1995, Journal of Cell Science.

[60]  A. Krämer.  The Biochemistry of PRE-mRNA Splicing , 1995 .

[61]  J. Beggs.  Yeast Splicing Factors and Genetic Strategies for Their Analysis , 1995 .

[62]  J. E. Mermoud,et al.  Regulation of mammalian spliceosome assembly by a protein phosphorylation mechanism. , 1994, The EMBO journal.

[63]  J. Steitz,et al.  SR proteins can compensate for the loss of U1 snRNP functions in vitro. , 1994, Genes & development.

[64]  Y. Shimura,et al.  Identification of a putative RNA helicase (HRH1), a human homolog of yeast Prp22 , 1994, Molecular and cellular biology.

[65]  R. Reed,et al.  SR proteins promote the first specific recognition of Pre-mRNA and are present together with the U1 small nuclear ribonucleoprotein particle in a general splicing enhancer complex , 1994, Molecular and cellular biology.

[66]  P. Sharp,et al.  Complementation by SR proteins of pre-mRNA splicing reactions depleted of U1 snRNP. , 1994, Science.

[67]  R. Reed,et al.  The prespliceosome components SAP 49 and SAP 145 interact in a complex implicated in tethering U2 snRNP to the branch site. , 1994, Genes & development.

[68]  T. Nilsen,et al.  RNA-RNA interactions in the spliceosome: Unraveling the ties that bind , 1994, Cell.

[69]  William Arbuthnot Sir Lane,et al.  A serine kinase regulates intracellular localization of splicing factors in the cell cycle , 1994, Nature.

[70]  S. Lockhart,et al.  Commitment of yeast pre-mRNA to the splicing pathway requires a novel U1 small nuclear ribonucleoprotein polypeptide, Prp39p. , 1994, Molecular and cellular biology.

[71]  M. Rosbash,et al.  The yeast MUD2 protein: an interaction with PRP11 defines a bridge between commitment complexes and U2 snRNP addition. , 1994, Genes & development.

[72]  M. Garcia-Blanco,et al.  Protein–protein interactions and 5'-splice-site recognition in mammalian mRNA precursors , 1994, Nature.

[73]  J. Beggs,et al.  RNA Splicing: U2 fulfils a commitment , 1994, Current Biology.

[74]  H. Madhani,et al.  Dynamic RNA-RNA interactions in the spliceosome. , 1994, Annual review of genetics.

[75]  P. Legrain,et al.  Splicing factor SF3a60 is the mammalian homologue of PRP9 of S.cerevisiae: the conserved zinc finger-like motif is functionally exchangeable in vivo. , 1994, Nucleic acids research.

[76]  Tom Maniatis,et al.  Specific interactions between proteins implicated in splice site selection and regulated alternative splicing , 1993, Cell.

[77]  R. Lührmann,et al.  Interaction of mammalian splicing factor SF3a with U2 snRNP and relation of its 60-kD subunit to yeast PRP9. , 1993, Science.

[78]  P. Legrain,et al.  Interaction between PRP11 and SPP91 yeast splicing factors and characterization of a PRP9-PRP11-SPP91 complex. , 1993, Science.

[79]  R. Reed,et al.  Correspondence between a mammalian spliceosome component and an essential yeast splicing factor. , 1993, Science.

[80]  H. Hauri,et al.  Separation of splicing factor SF3 into two components and purification of SF3a activity. , 1993, The Journal of biological chemistry.

[81]  J. Tazi,et al.  Thiophosphorylation of U1-70K protein inhibits pre-mRNA splicing , 1993, Nature.

[82]  Phillip A. Sharp,et al.  13 Splicing of Precursors to mRNA by the Spliceosome , 1993 .

[83]  C. Guthrie,et al.  A conformational rearrangement in the spliceosome is dependent on PRP16 and ATP hydrolysis. , 1992, The EMBO journal.

[84]  P. Zamore,et al.  Cloning and intracellular localization of the U2 small nuclear ribonucleoprotein auxiliary factor small subunit. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[85]  J. Smith,et al.  The purified yeast pre‐mRNA splicing factor PRP2 is an RNA‐dependent NTPase. , 1992, The EMBO journal.

[86]  Michael R. Green,et al.  Cloning and domain structure of the mammalian splicing factor U2AF , 1992, Nature.

[87]  D. Rio.  RNA binding proteins, splice site selection, and alternative pre-mRNA splicing. , 1992, Gene expression.

[88]  C. Guthrie,et al.  PRP16 is an RNA-dependent ATPase that interacts transiently with the spliceosome , 1991, Nature.

[89]  T. Maniatis,et al.  Mechanisms of alternative pre-mRNA splicing. , 1991, Science.

[90]  M. Green,et al.  Biochemical characterization of U2 snRNP auxiliary factor: an essential pre‐mRNA splicing factor with a novel intranuclear distribution. , 1991, The EMBO journal.

[91]  R. Lührmann,et al.  Conservation between yeast and man of a protein associated with U5 small nuclear ribonucleoprotein , 1989, Nature.

[92]  B. Ganem.  RNA world , 1987, Nature.