Selective role of the catalytic PI3K subunit p110β in impaired higher order cognition in fragile X syndrome.
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J. Gibson | C. Gross | G. Bassell | S. Gourley | A. G. Allen | Alonzo J. Whyte | G. Molinaro | Nisha Raj | K. Huber
[1] Seth M. Kelly,et al. Increased expression of the PI3K enhancer PIKE mediates deficits in synaptic plasticity and behavior in fragile X syndrome. , 2015, Cell reports.
[2] E. Klann,et al. Identification of Fragile X Syndrome Specific Molecular Markers in Human Fibroblasts: A Useful Model to Test the Efficacy of Therapeutic Drugs , 2014, Human mutation.
[3] Simon Killcross,et al. Orbitofrontal cortex inactivation impairs between- but not within-session Pavlovian extinction: An associative analysis , 2014, Neurobiology of Learning and Memory.
[4] G. Schoenbaum,et al. Neural Estimates of Imagined Outcomes in the Orbitofrontal Cortex Drive Behavior and Learning , 2013, Neuron.
[5] JaneR . Taylor,et al. The orbitofrontal cortex regulates outcome‐based decision‐making via the lateral striatum , 2013, The European journal of neuroscience.
[6] J. Tiago Gonçalves,et al. Circuit level defects in the developing neocortex of fragile X mice , 2013, Nature Neuroscience.
[7] C. Winstanley,et al. Functional Disconnection of the Orbitofrontal Cortex and Basolateral Amygdala Impairs Acquisition of a Rat Gambling Task and Disrupts Animals' Ability to Alter Decision-Making Behavior after Reinforcer Devaluation , 2013, The Journal of Neuroscience.
[8] M. Dierssen,et al. Targeting the endocannabinoid system in the treatment of fragile X syndrome , 2013, Nature Medicine.
[9] JaneR . Taylor,et al. Action control is mediated by prefrontal BDNF and glucocorticoid receptor binding , 2012, Proceedings of the National Academy of Sciences.
[10] Uwe Ohler,et al. FMR1 targets distinct mRNA sequence elements to regulate protein expression , 2012, Nature.
[11] E. Klann,et al. Genetic Removal of p70 S6 Kinase 1 Corrects Molecular, Synaptic, and Behavioral Phenotypes in Fragile X Syndrome Mice , 2012, Neuron.
[12] C. Gross,et al. Excess Protein Synthesis in FXS Patient Lymphoblastoid Cells Can Be Rescued with a p110β-Selective Inhibitor , 2012, Molecular medicine.
[13] Mark F Bear,et al. The pathophysiology of fragile X (and what it teaches us about synapses). , 2012, Annual review of neuroscience.
[14] J. Gibson,et al. Altered Neocortical Rhythmic Activity States in Fmr1 KO Mice Are Due to Enhanced mGluR5 Signaling and Involve Changes in Excitatory Circuitry , 2011, The Journal of Neuroscience.
[15] R. Paylor,et al. Genetic reduction of group 1 metabotropic glutamate receptors alters select behaviors in a mouse model for fragile X syndrome , 2011, Behavioural Brain Research.
[16] J. Fak,et al. FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism , 2011, Cell.
[17] M. Bear,et al. Hypersensitivity to mGluR5 and ERK1/2 Leads to Excessive Protein Synthesis in the Hippocampus of a Mouse Model of Fragile X Syndrome , 2010, The Journal of Neuroscience.
[18] Mika Nakamoto,et al. Excess Phosphoinositide 3-Kinase Subunit Synthesis and Activity as a Novel Therapeutic Target in Fragile X Syndrome , 2010, The Journal of Neuroscience.
[19] E. Klann,et al. Dysregulation of mTOR Signaling in Fragile X Syndrome , 2010, The Journal of Neuroscience.
[20] JaneR . Taylor,et al. Prelimbic cortex bdnf knock-down reduces instrumental responding in extinction. , 2009, Learning & memory.
[21] E. Coutureau,et al. Transient role of the rat prelimbic cortex in goal‐directed behaviour , 2009, The European journal of neuroscience.
[22] R. Costa,et al. Chronic Stress Causes Frontostriatal Reorganization and Affects Decision-Making , 2009, Science.
[23] E. Coutureau,et al. Goal-directed responding is sensitive to lesions to the prelimbic cortex or basolateral nucleus of the amygdala but not to their disconnection. , 2009, Behavioral neuroscience.
[24] Derek G. V. Mitchell,et al. Dissociable roles of medial orbitofrontal cortex in human operant extinction learning , 2008, NeuroImage.
[25] J. Gibson,et al. Imbalance of neocortical excitation and inhibition and altered UP states reflect network hyperexcitability in the mouse model of fragile X syndrome. , 2008, Journal of neurophysiology.
[26] K. Okkenhaug,et al. The p110β isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110γ , 2008, Proceedings of the National Academy of Sciences.
[27] M. Packard,et al. Medial prefrontal cortex infusions of bupivacaine or AP-5 block extinction of amphetamine conditioned place preference , 2008, Neurobiology of Learning and Memory.
[28] Alison S Fleming,et al. Medial prefrontal cortex lesions in the female rat affect sexual and maternal behavior and their sequential organization. , 2007, Behavioral neuroscience.
[29] E. Schuman,et al. Dendritic Protein Synthesis, Synaptic Plasticity, and Memory , 2006, Cell.
[30] R. Deacon. Assessing nest building in mice , 2006, Nature Protocols.
[31] M. Tranfaglia,et al. Suppression of two major Fragile X Syndrome mouse model phenotypes by the mGluR5 antagonist MPEP , 2005, Neuropharmacology.
[32] Alicia Izquierdo,et al. Opposing effects of amygdala and orbital prefrontal cortex lesions on the extinction of instrumental responding in macaque monkeys , 2005, The European journal of neuroscience.
[33] B. Balleine,et al. Lesions of Medial Prefrontal Cortex Disrupt the Acquisition But Not the Expression of Goal-Directed Learning , 2005, The Journal of Neuroscience.
[34] T. Robbins,et al. Prefrontal executive and cognitive functions in rodents: neural and neurochemical substrates , 2004, Neuroscience & Biobehavioral Reviews.
[35] I. Weiler,et al. Fragile X mental retardation protein is necessary for neurotransmitter-activated protein translation at synapses. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[36] R. Dolan,et al. Human orbitofrontal cortex mediates extinction learning while accessing conditioned representations of value , 2004, Nature Neuroscience.
[37] Mark F Bear,et al. The mGluR theory of fragile X mental retardation , 2004, Trends in Neurosciences.
[38] B. Balleine,et al. The role of prelimbic cortex in instrumental conditioning , 2003, Behavioural Brain Research.
[39] E. Nagata,et al. PI3 kinase enhancer–Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis , 2003, Nature Neuroscience.
[40] S. Killcross,et al. Coordination of actions and habits in the medial prefrontal cortex of rats. , 2003, Cerebral cortex.
[41] I. Weiler,et al. RNA Cargoes Associating with FMRP Reveal Deficits in Cellular Functioning in Fmr1 Null Mice , 2003, Neuron.
[42] R. Nussbaum,et al. Early embryonic lethality in mice deficient in the p110β catalytic subunit of PI 3-kinase , 2002, Mammalian Genome.
[43] B. Balleine,et al. Goal-directed instrumental action: contingency and incentive learning and their cortical substrates , 1998, Neuropharmacology.
[44] P. McGuffin,et al. Prevention by cycloheximide of the audiogenic seizures and tryptophan metabolic disturbances of ethanol withdrawal in rats. , 1996, Alcohol and alcoholism.
[45] L. J. Hammond. The effect of contingency upon the appetitive conditioning of free-operant behavior. , 1980, Journal of the experimental analysis of behavior.
[46] B. Balleine,et al. Human and Rodent Homologies in Action Control: Corticostriatal Determinants of Goal-Directed and Habitual Action , 2010, Neuropsychopharmacology.
[47] M. Mishkin,et al. Conditioning and extinction of a food-rewarded response after selective ablations of frontal cortex in rhesus monkeys. , 1963, Experimental neurology.