Evidence for impaired assimilation and increased colonic fermentation of protein, related to gastric acid suppression therapy

Although the role of gastric digestion (by acid‐dependent pepsins) in overall protein assimilation has never thoroughly been studied, it is generally considered to be limited. Protein that escapes assimilation in the small intestine is intensely fermented by the colonic flora. Phenol and p‐cresol are specific bacterial metabolites of tyrosine.

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