Kisspeptin Induces Dynamic Chromatin Modifications to Control GnRH Gene Expression

[1]  S. Radovick,et al.  Disrupted kisspeptin signaling in GnRH neurons leads to hypogonadotrophic hypogonadism. , 2014, Molecular endocrinology.

[2]  J. R. Kurian,et al.  Epigenetic Control of Gonadotropin Releasing Hormone Neurons , 2013, Front. Endocrinol..

[3]  S. Ojeda,et al.  Epigenetic Control of Female Puberty , 2013, Nature Neuroscience.

[4]  S. Radovick,et al.  Genetic Mechanisms Mediating Kisspeptin Regulation of GnRH gene Expression , 2012, The Journal of Neuroscience.

[5]  Y. Liu,et al.  Histone Deacetylases Regulate Gonadotropin-Releasing Hormone I Gene Expression via Modulating Otx2-Driven Transcriptional Activity , 2012, PloS one.

[6]  Satoshi Tanaka,et al.  Epigenetic regulation of Kiss1 gene expression mediating estrogen-positive feedback action in the mouse brain , 2012, Proceedings of the National Academy of Sciences.

[7]  S. Spicuglia,et al.  H3K4 tri‐methylation provides an epigenetic signature of active enhancers , 2011, The EMBO journal.

[8]  F. Wondisford,et al.  Deletion of Otx2 in GnRH neurons results in a mouse model of hypogonadotropic hypogonadism. , 2011, Molecular endocrinology.

[9]  P. Mellon,et al.  Dynamic chromatin modifications control GnRH gene expression during neuronal differentiation and protein kinase C signal transduction. , 2011, Molecular endocrinology.

[10]  J. R. Kurian,et al.  Epigenetic changes coincide with in vitro primate GnRH neuronal maturation. , 2010, Endocrinology.

[11]  澄人 伊達木.  Heterozygous orthodenticle homeobox 2 mutations are associated with variable pituitary phenotype , 2010 .

[12]  S. Radovick,et al.  Kisspeptin increases GnRH mRNA expression and secretion in GnRH secreting neuronal cell lines , 2009, Molecular and Cellular Endocrinology.

[13]  P. Mellon,et al.  Otx2 Induction of the Gonadotropin-releasing Hormone Promoter Is Modulated by Direct Interactions with Grg Co-repressors* , 2009, The Journal of Biological Chemistry.

[14]  David Handelsman,et al.  Kisspeptins and the control of gonadotropin secretion in male and female rodents , 2009, Peptides.

[15]  S. Radovick,et al.  A novel dominant negative mutation of OTX2 associated with combined pituitary hormone deficiency. , 2008, The Journal of clinical endocrinology and metabolism.

[16]  T. Ogata,et al.  OTX2 mutation in a patient with anophthalmia, short stature, and partial growth hormone deficiency: functional studies using the IRBP, HESX1, and POU1F1 promoters. , 2008, The Journal of clinical endocrinology and metabolism.

[17]  J. Andrau,et al.  Genome-wide RNA polymerase II: not genes only! , 2008, Trends in biochemical sciences.

[18]  Keisuke Hitachi,et al.  Molecular links among the causative genes for ocular malformation: Otx2 and Sox2 coregulate Rax expression , 2008, Proceedings of the National Academy of Sciences.

[19]  F. Gaytán,et al.  Opposite roles of estrogen receptor (ER)-alpha and ERbeta in the modulation of luteinizing hormone responses to kisspeptin in the female rat: implications for the generation of the preovulatory surge. , 2008, Endocrinology.

[20]  S. Moenter,et al.  Kisspeptin acts directly and indirectly to increase gonadotropin-releasing hormone neuron activity and its effects are modulated by estradiol. , 2008, Endocrinology.

[21]  Felecia Cerrato,et al.  Kiss1-/- mice exhibit more variable hypogonadism than Gpr54-/- mice. , 2007, Endocrinology.

[22]  S. Seminara.  Kisspeptin in reproduction. , 2007, Seminars in reproductive medicine.

[23]  M. C. Jeziorski,et al.  17-Beta-Estradiol Directly Regulates the Expression of Adrenergic Receptors and Kisspeptin/GPR54 System in GT1-7 GnRH Neurons , 2007, Neuroendocrinology.

[24]  G. Fan,et al.  Epigenetic Regulation of Neural Gene Expression and Neuronal Function , 2007, Pediatric Research.

[25]  Nathaniel D. Heintzman,et al.  Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome , 2007, Nature Genetics.

[26]  N. de Roux,et al.  Neuroendocrine phenotype analysis in five patients with isolated hypogonadotropic hypogonadism due to a L102P inactivating mutation of GPR54. , 2007, The Journal of clinical endocrinology and metabolism.

[27]  T. Kouzarides.  Chromatin Modifications and Their Function , 2007, Cell.

[28]  Bing Li,et al.  The Role of Chromatin during Transcription , 2007, Cell.

[29]  E. Lander,et al.  The Mammalian Epigenome , 2007, Cell.

[30]  Amanda L. Johnson,et al.  In vivo identification of a 107-base pair promoter element mediating neuron-specific expression of mouse gonadotropin-releasing hormone. , 2007, Molecular endocrinology.

[31]  R. Steiner,et al.  Kisspepeptin-GPR54 signaling in the neuroendocrine reproductive axis , 2006, Molecular and Cellular Endocrinology.

[32]  Leah Barrera,et al.  The transcriptional regulatory code of eukaryotic cells--insights from genome-wide analysis of chromatin organization and transcription factor binding. , 2006, Current opinion in cell biology.

[33]  A. Miele,et al.  Mapping Chromatin Interactions by Chromosome Conformation Capture , 2006, Current protocols in molecular biology.

[34]  F. Gage,et al.  Chromatin remodeling in neural development and plasticity. , 2005, Current opinion in cell biology.

[35]  S. Bloom,et al.  Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human males. , 2005, The Journal of clinical endocrinology and metabolism.

[36]  D. Ma,et al.  Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[37]  F. Gage,et al.  Epigenetic control of neural stem cell fate. , 2004, Current opinion in genetics & development.

[38]  F. Monsma,et al.  The KiSS-1 receptor GPR54 is essential for the development of the murine reproductive system. , 2003, Biochemical and biophysical research communications.

[39]  Danny Reinberg,et al.  Histone lysine methylation: a signature for chromatin function. , 2003, Trends in genetics : TIG.

[40]  J. Lis,et al.  Transcription Factor and Polymerase Recruitment, Modification, and Movement on dhsp70 In Vivo in the Minutes following Heat Shock , 2003, Molecular and Cellular Biology.

[41]  S. O’Rahilly,et al.  The GPR54 Gene as a Regulator of Puberty , 2003 .

[42]  E. Génin,et al.  Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54 , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[43]  P. Sharp,et al.  RNA Polymerase II Accumulation in the Promoter-Proximal Region of the Dihydrofolate Reductase and γ-Actin Genes , 2003, Molecular and Cellular Biology.

[44]  S. Radovick,et al.  Identification of a discrete promoter region of the human GnRH gene that is sufficient for directing neuron-specific expression: a role for POU homeodomain transcription factors. , 2002, Molecular endocrinology.

[45]  J. Dekker,et al.  Capturing Chromosome Conformation , 2002, Science.

[46]  C. Allis,et al.  Translating the Histone Code , 2001, Science.

[47]  E. Cho,et al.  Different phosphorylated forms of RNA polymerase II and associated mRNA processing factors during transcription. , 2000, Genes & development.

[48]  P. Mellon,et al.  Neuron-specific expression of the rat gonadotropin-releasing hormone gene is conferred by interactions of a defined promoter element with the enhancer in GT1-7 cells. , 2000, Molecular endocrinology.

[49]  S. Aizawa,et al.  OTX2 directly interacts with LIM1 and HNF-3beta. , 2000, Biochemical and biophysical research communications.

[50]  P. Mellon,et al.  Oct-1 binds promoter elements required for transcription of the GnRH gene. , 1998, Molecular endocrinology.

[51]  J. Levine,et al.  New concepts of the neuroendocrine regulation of gonadotropin surges in rats. , 1997, Biology of reproduction.

[52]  A. Herbison,et al.  Gonadotropin-releasing hormone (GnRH) neuron requirements for puberty, ovulation and fertility , 2018 .

[53]  M. Phillip,et al.  A novel loss-of-function mutation in GPR54/KISS1R leads to hypogonadotropic hypogonadism in a highly consanguineous family. , 2011, The Journal of clinical endocrinology and metabolism.

[54]  Job Dekker,et al.  The three 'C' s of chromosome conformation capture: controls, controls, controls , 2005, Nature Methods.

[55]  P. Magni,et al.  Characterization of the potent luteinizing hormone-releasing activity of KiSS-1 peptide, the natural ligand of GPR54. , 2005, Endocrinology.

[56]  Chonghui Cheng,et al.  RNA polymerase II accumulation in the promoter-proximal region of the dihydrofolate reductase and gamma-actin genes. , 2003, Molecular and cellular biology.