Contextual social cognition and the behavioral variant of frontotemporal dementia

The significance of social situations is commonly context-embedded. Although the role of context has been extensively studied in basic sensory processing or simple stimulus-response settings, its relevance for social cognition is unknown. We propose the social context network model (SCNM), a fronto-insular-temporal network responsible for processing social contextual effects. The SCNM may 1) update the context and use it to make predictions, 2) coordinate internal and external milieus, and 3) consolidate context-target associative learning. We suggest the behavioral variant of frontotemporal dementia (bvFTD) as a specific disorder in which the reported deficits in social cognition (e.g., facial recognition, empathy, decision-making, figurative language, theory of mind) can be described as context impairments due to deficits in the SCNM. Disruption of orbitofrontal-amygdala circuit, as well as the frontal, temporal, and insular atrophy in bVFTD, suggests a relationship between context-sensitive social cognition and SCNM. In considering context as an intrinsic part of social cognition, we highlight the need for a situated cognition approach in social cognition research as opposed to an abstract, universal, and decontextualized approach. The assessment of context-dependent social cognition paradigms, the SCNM, and their possible application to neuropsychiatric disorders may provide new insight into bvFTD and other related frontal disorders.

[1]  R. Faber,et al.  Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria. , 1999, Neurology.

[2]  M. Mesulam Frontal cortex and behavior , 1986, Annals of neurology.

[3]  P. Hagoort On Broca, brain, and binding: a new framework , 2005, Trends in Cognitive Sciences.

[4]  N. Roberts,et al.  Theories of episodic memory. , 2001, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[5]  Facundo Manes,et al.  A neuropsychological battery to detect specific executive and social cognitive impairments in early frontotemporal dementia. , 2009, Brain : a journal of neurology.

[6]  Facundo Manes,et al.  Decision-making cognition in neurodegenerative diseases , 2010, Nature Reviews Neurology.

[7]  E. D. Paolo,et al.  Can social interaction constitute social cognition? , 2010, Trends in Cognitive Sciences.

[8]  S. Ullman,et al.  Spatial Context in Recognition , 1996, Perception.

[9]  Nick C Fox,et al.  Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia. , 2011, Brain : a journal of neurology.

[10]  A. Craig How do you feel? Interoception: the sense of the physiological condition of the body , 2002, Nature Reviews Neuroscience.

[11]  R. von der Heydt,et al.  Analysis of the Context Integration Mechanisms Underlying Figure–Ground Organization in the Visual Cortex , 2010, The Journal of Neuroscience.

[12]  F. Hadžiselimović,et al.  Importance of Early Postnatal Germ Cell Maturation for Fertility of Cryptorchid Males , 2001, Hormone Research in Paediatrics.

[13]  Guy B. Williams,et al.  Neural correlates of semantic and behavioural deficits in frontotemporal dementia , 2005, NeuroImage.

[14]  R. Adolphs,et al.  The social brain: neural basis of social knowledge. , 2009, Annual review of psychology.

[15]  Indre V. Viskontas,et al.  Symptoms of Frontotemporal Dementia Provide Insights into Orbitofrontal Cortex Function and Social Behavior , 2007, Annals of the New York Academy of Sciences.

[16]  H. Meeren,et al.  Rapid perceptual integration of facial expression and emotional body language. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[17]  Kai Vogeley,et al.  Contextualising culture and social cognition , 2009, Trends in Cognitive Sciences.

[18]  Moshe Bar,et al.  See it with feeling: affective predictions during object perception , 2009, Philosophical Transactions of the Royal Society B: Biological Sciences.

[19]  F. Manes,et al.  Human Neuroscience , 2022 .

[20]  John R. Hodges,et al.  Social reasoning, emotion and empathy in frontotemporal dementia , 2006, Neuropsychologia.

[21]  Moshe Bar,et al.  The proactive brain: memory for predictions , 2009, Philosophical Transactions of the Royal Society B: Biological Sciences.

[22]  Luke Clark,et al.  The relationship between affective decision-making and theory of mind in the frontal variant of fronto-temporal dementia , 2007, Neuropsychologia.

[23]  M. Bouton,et al.  Contextual and Temporal Modulation of Extinction: Behavioral and Biological Mechanisms , 2006, Biological Psychiatry.

[24]  Sasha Bozeat,et al.  Which neuropsychiatric and behavioural features distinguish frontal and temporal variants of frontotemporal dementia from Alzheimer's disease? , 2000, Journal of neurology, neurosurgery, and psychiatry.

[25]  F. Manes,et al.  Clinical effects of insular damage in humans , 2010, Brain Structure and Function.

[26]  D. Bilkey Space and context in the temporal cortex , 2007, Hippocampus.

[27]  Maria Luisa Gorno-Tempini,et al.  Structural anatomy of empathy in neurodegenerative disease. , 2006, Brain : a journal of neurology.

[28]  J. Fuster Overview of Prefrontal Functions: The Temporal Organization of Action , 2008 .

[29]  Facundo Manes,et al.  High contextual sensitivity of metaphorical expressions and gesture blending: A video event-related potential design , 2011, Psychiatry Research: Neuroimaging.

[30]  J. Hodges,et al.  Behavioural-variant frontotemporal dementia: diagnosis, clinical staging, and management , 2011, The Lancet Neurology.

[31]  H. Critchley,et al.  A common role of insula in feelings, empathy and uncertainty , 2009, Trends in Cognitive Sciences.

[32]  W. Seeley,et al.  Selective functional, regional, and neuronal vulnerability in frontotemporal dementia , 2008, Current opinion in neurology.

[33]  K. Zilles,et al.  A link between the systems: functional differentiation and integration within the human insula revealed by meta-analysis , 2010, Brain Structure and Function.

[34]  John Duncan,et al.  Hierarchical coding for sequential task events in the monkey prefrontal cortex , 2008, Proceedings of the National Academy of Sciences.

[35]  Emma R Wood,et al.  Associative recognition and the hippocampus: Differential effects of hippocampal lesions on object‐place, object‐context and object‐place‐context memory , 2009, Hippocampus.

[36]  M. Mesulam,et al.  The human frontal lobes: Transcending the default mode through contingent encoding. , 2002 .

[37]  Helen Barbas,et al.  Sensory Pathways and Emotional Context for Action in Primate Prefrontal Cortex , 2011, Biological Psychiatry.

[38]  Joel H Kramer,et al.  Double dissociation of social functioning in frontotemporal dementia , 2003, Neurology.

[39]  M. Bar Visual objects in context , 2004, Nature Reviews Neuroscience.

[40]  P. Dayan,et al.  Space and time in visual context , 2007, Nature Reviews Neuroscience.

[41]  Masataka Watanabe,et al.  Integration of cognitive and motivational context information in the primate prefrontal cortex. , 2007, Cerebral cortex.

[42]  C. Petten,et al.  Neural localization of semantic context effects in electromagnetic and hemodynamic studies , 2006, Brain and Language.

[43]  Marina Boccardi,et al.  Frontotemporal dementia as a neural system disease , 2005, Neurobiology of Aging.

[44]  D. Barch,et al.  The effect of context processing on different aspects of social cognition in schizophrenia. , 2011, Schizophrenia bulletin.

[45]  Katherine P. Rankin,et al.  Detecting sarcasm from paralinguistic cues: Anatomic and cognitive correlates in neurodegenerative disease , 2009, NeuroImage.

[46]  William L. Gross,et al.  An fMRI Analysis of the Human Hippocampus: Inference, Context, and Task Awareness , 2006, Journal of Cognitive Neuroscience.

[47]  F. Manes,et al.  When context is difficult to integrate: Cortical measures of congruency in schizophrenics and healthy relatives from multiplex families , 2011, Schizophrenia Research.

[48]  John Duncan,et al.  Detection of Fixed and Variable Targets in the Monkey Prefrontal Cortex , 2009, Cerebral cortex.

[49]  J. Hodges Frontotemporal dementia (Pick’s disease): Clinical features and assessment , 2001, Neurology.

[50]  F. Manes,et al.  Decision-Making in Frontotemporal Dementia: Clinical, Theoretical and Legal Implications , 2011, Dementia and Geriatric Cognitive Disorders.

[51]  Scott T. Grafton Embodied Cognition and the Simulation of Action to Understand Others , 2009, Annals of the New York Academy of Sciences.

[52]  P. Niedenthal Embodying Emotion , 2007, Science.

[53]  Vladimir López,et al.  ERPs and contextual semantic discrimination: Degrees of congruence in wakefulness and sleep , 2006, Brain and Language.

[54]  John Duncan,et al.  The role of Area 10 (BA10) in human multitasking and in social cognition: A lesion study , 2011, Neuropsychologia.

[55]  B. Gelder Towards the neurobiology of emotional body language , 2006, Nature Reviews Neuroscience.

[56]  F. Manes,et al.  Applauding with Closed Hands: Neural Signature of Action-Sentence Compatibility Effects , 2010, PloS one.

[57]  Edwin Hutchins,et al.  The role of cultural practices in the emergence of modern human intelligence , 2008, Philosophical Transactions of the Royal Society B: Biological Sciences.

[58]  R. Benoit,et al.  Mesulam's frontal lobe mystery re-examined. , 2009, Restorative neurology and neuroscience.

[59]  Kristen A. Lindquist,et al.  Opinion TRENDS in Cognitive Sciences Vol.11 No.8 Cognitive-emotional interactions Language as context for the , 2022 .