Use of natural antioxidants to scavenge free radicals: a major cause of diseases.

Damage to cells caused by free radicals is believed to play a central role in the aging process and in disease progression. Antioxidants are our first line of defense against free radical damage, and are critical for maintaining optimum health and wellbeing. The need for antioxidants becomes even more critical with increased exposure to free radicals. Pollution, cigarette smoke, drugs, illness, stress, and even exercise can increase free radical exposure. Because so many factors can contribute to oxidative stress, individual assessment of susceptibility becomes important. Free radical scavenger may prevent the oxidative stress by peroxidation, inhibiting free radicals and also by other mechanism can prevent disease. Antioxidants are intimately involved in the prevention of cellular damage the common pathway for cancer, aging, and a variety of diseases. The present review article is an attempt to generate interest and awareness that, free radical is a major cause of many diseases.

[1]  K. Pihlaja,et al.  The structural and conformational analyses and antioxidant activities of chebulinic acid and its thrice-hydrolyzed derivative, 2,4-chebuloyl-β-D-glucopyranoside, isolated from the fruit of Terminalia chebula , 2004 .

[2]  T. Kinoshita,et al.  Identification of antimicrobial and antioxidant constituents from licorice of Russian and Xinjiang origin. , 1989, Chemical & pharmaceutical bulletin.

[3]  S. Erken Rosmarinus officinalis L , 2007 .

[4]  I. Fridovich,et al.  The reduction of cytochrome c by milk xanthine oxidase. , 1968, The Journal of biological chemistry.

[5]  L. Kirshenbaum,et al.  A relative deficit in antioxidant reserve may contribute in cardiac failure. , 1990, The Canadian journal of cardiology.

[6]  D. Liebler The role of metabolism in the antioxidant function of vitamin E. , 1993, Critical reviews in toxicology.

[7]  R. Hiipakka,et al.  Selective inhibition of steroid 5 alpha-reductase isozymes by tea epicatechin-3-gallate and epigallocatechin-3-gallate. , 1995, Biochemical and biophysical research communications.

[8]  V. N. Gupta,et al.  3,4,5-Trihydroxy benzoic acid (gallic acid), the hepatoprotective principle in the fruits of Terminalia belerica-bioassay guided activity. , 1997, Pharmacological research.

[9]  D. Ross,et al.  The generation and subsequent fate of glutathionyl radicals in biological systems. , 1985, Journal of Biological Chemistry.

[10]  M. Katan,et al.  Tea flavonoids and cardiovascular disease: a review. , 1997, Critical reviews in food science and nutrition.

[11]  S. K. Ghosal,et al.  Antioxidant activity ofBacopa monniera in rat frontal cortex, striatum and hippocampus , 2000, Phytotherapy research : PTR.

[12]  D. Mshelia Role of free radicals in pathogenesis of diabetes nephropathy , 2004 .

[13]  Chun-ching Lin,et al.  Antioxidant and hepatoprotective effects of punicalagin and punicalin on acetaminophen‐induced liver damage in rats , 2001, Phytotherapy research : PTR.

[14]  T. Moriguchi,et al.  Antioxidant and Radical Scavenging Effects of Aged Garlic Extract and its Constituents , 1994, Planta medica.

[15]  J. Larsen,et al.  Cancer-protective factors in fruits and vegetables: biochemical and biological background. , 1993, Pharmacology & toxicology.

[16]  P. Mapp,et al.  Hypoxia, oxidative stress and rheumatoid arthritis. , 1995, British medical bulletin.

[17]  K. Igarashi,et al.  Effects of isorhamnetin, rhamnetin, and quercetin on the concentrations of cholesterol and lipoperoxide in the serum and liver and on the blood and liver antioxidative enzyme activities of rats. , 1995, Bioscience, biotechnology, and biochemistry.

[18]  Chi-Tang Ho,et al.  Antioxidative components of tanshen (Salvia miltiorhiza Bung) , 1990 .

[19]  R. Armon,et al.  Cinnamon extracts' inhibitory effect on Helicobacter pylori. , 1999, Journal of ethnopharmacology.

[20]  A. Qureshi,et al.  Lowering of serum cholesterol in hypercholesterolemic humans by tocotrienols (palmvitee). , 1991, The American journal of clinical nutrition.

[21]  周钟欣 Extract , 1867, The Indian medical gazette.

[22]  J. S. Morris,et al.  Serum micronutrients and the subsequent risk of cervical cancer in a population-based nested case-control study. , 1993, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[23]  O. Sommerburg,et al.  Fruits and vegetables that are sources for lutein and zeaxanthin: the macular pigment in human eyes , 1998, The British journal of ophthalmology.

[24]  A. Neil,et al.  Garlic as a Lipid Lowering Agent—A Meta-Analysis , 1994, Journal of the Royal College of Physicians of London.

[25]  Mustafa Atalay,et al.  Diabetes, oxidative stress and physical exercise. , 2002, Journal of sports science & medicine.

[26]  C. S. Yang,et al.  Inhibition of cytochrome P-450 2E1 by diallyl sulfide and its metabolites. , 1991, Chemical research in toxicology.

[27]  Daniel Steinberg,et al.  Low Density Lipoprotein Oxidation and Its Pathobiological Significance* , 1997, The Journal of Biological Chemistry.

[28]  M. Irshad,et al.  Oxidant-antioxidant system: role and significance in human body. , 2002, Indian journal of experimental biology.

[29]  A. Kapil,et al.  Effect of diterpenes from Andrographis paniculata on antioxidant defense system and lipid peroxidation , 1994 .

[30]  N. K. Kapoor,et al.  Effect of picroliv on glutathione metabolism in liver and brain of Mastomys natalensis infected with Plasmodium berghei. , 1992, Indian journal of experimental biology.

[31]  J. C. Smith,et al.  Lutein, lycopene, and their oxidative metabolites in chemoprevention of cancer , 1995, Journal of cellular biochemistry. Supplement.

[32]  Christopher J. Rhodes,et al.  Role of oxygen radicals in DNA damage and cancer incidence , 2004, Molecular and Cellular Biochemistry.

[33]  Z. Naito,et al.  Pathogenesis and protection of ischemia and reperfusion injury in myocardium. , 2003, Journal of Nippon Medical School = Nippon Ika Daigaku zasshi.

[34]  S. Kapur,et al.  Free Radicals and Oxidative Stress in Neurodegenerative Diseases : Relevance of Dietary Antioxidants , 2004 .

[35]  N. Suttorp,et al.  Antioxidant defense mechanisms of endothelial cells: glutathione redox cycle versus catalase. , 1986, The American journal of physiology.

[36]  S. Renaud,et al.  Wine, alcohol, platelets, and the French paradox for coronary heart disease , 1992, The Lancet.

[37]  P. Scartezzini,et al.  Review on some plants of Indian traditional medicine with antioxidant activity. , 2000, Journal of ethnopharmacology.

[38]  A. Valenzuela,et al.  Silybin Dihemisuccinate Protects Rat Erythrocytes Against Phenylhydrazine-Induced Lipid Peroxidation and Hemolysis , 1987, Planta medica.

[39]  C. Elson,et al.  Suppression of mevalonate pathway activities by dietary isoprenoids: protective roles in cancer and cardiovascular disease. , 1995, The Journal of nutrition.

[40]  M. Rao,et al.  Dehydrozingerone and isoeugenol as inhibitors of lipid peroxidation and as free radical scavengers. , 1993, Biochemical pharmacology.

[41]  E. Niki Antioxidants and atherosclerosis. , 2004, Biochemical Society transactions.

[42]  Dewa Ngurah Suprapta,et al.  Antioxidant activity of tropical ginger extracts and analysis of the contained curcuminoids , 1992 .

[43]  C. D. De Mey,et al.  Efficacy and Tolerability of Myrtol Standardized in Long-term Treatment of Chronic Bronchitis , 1999, Arzneimittelforschung.

[44]  D. Das,et al.  Cardioprotective effects of grape seed proanthocyanidin against ischemic reperfusion injury. , 1999, Journal of molecular and cellular cardiology.

[45]  A. Bast,et al.  Oxidants and antioxidants: state of the art. , 1991, The American journal of medicine.

[46]  Hiroyuki Tsutsui,et al.  [Oxidative stress and heart failure]. , 2006, Nihon rinsho. Japanese journal of clinical medicine.

[47]  M. Höllwarth,et al.  Ischemia-reperfusion injury: role of oxygen-derived free radicals. , 1986, Acta physiologica Scandinavica. Supplementum.

[48]  S. Maxwell Prospects for the Use of Antioxidant Therapies , 1995, Drugs.

[49]  R. Gryglewski,et al.  Flavonoids are scavengers of superoxide anions. , 1988, Biochemical pharmacology.

[50]  W. Regelson,et al.  Review of the biology of Quercetin and related bioflavonoids. , 1995, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[51]  B. Ames,et al.  The free radical theory of aging matures. , 1998, Physiological reviews.