The ‘correlates’ in neural correlates of consciousness

In the search for neural correlates of consciousness (NCC), the concept of 'consciousness' remains problematic. We suggest that not only the 'consciousness' in neural correlates of consciousness is a confused term, but 'correlates' is as well. When brain events are found to covary with conscious experience, these brain events can be the neural substrates of the experience, as is often (implicitly) suggested, but they can also be neural prerequisites or neural consequences of the experience. We here disentangle these different sorts of brain processes conceptually. But we also propose a concrete multi-pronged research program that may, in near-future consciousness research, distinguish these brain processes empirically.

[1]  Signe Vangkilde,et al.  The earliest electrophysiological correlate of visual awareness? , 2008, Brain and Cognition.

[2]  V. Walsh,et al.  Right parietal TMS shortens dominance durations in binocular rivalry , 2010, Current Biology.

[3]  Toshio Inui,et al.  Neural substrates for depth perception of the Necker cube; a functional magnetic resonance imaging study in human subjects , 2000, Neuroscience Letters.

[4]  R. Passingham,et al.  Relative blindsight in normal observers and the neural correlate of visual consciousness , 2006, Proceedings of the National Academy of Sciences.

[5]  J. Driver,et al.  Visibility Reflects Dynamic Changes of Effective Connectivity between V1 and Fusiform Cortex , 2005, Neuron.

[6]  J. Hohwy The neural correlates of consciousness: New experimental approaches needed? , 2009, Consciousness and Cognition.

[7]  Andreas Kleinschmidt,et al.  Spontaneous local variations in ongoing neural activity bias perceptual decisions , 2008, Proceedings of the National Academy of Sciences.

[8]  N. Block Two neural correlates of consciousness , 2005, Trends in Cognitive Sciences.

[9]  L. Nyberg,et al.  Common fronto-parietal activity in attention, memory, and consciousness: Shared demands on integration? , 2005, Consciousness and Cognition.

[10]  Leslie G. Ungerleider,et al.  Neuroimaging Studies of Attention: From Modulation of Sensory Processing to Top-Down Control , 2003, The Journal of Neuroscience.

[11]  Semir Zeki,et al.  Seeing Invisible Motion: A Human fMRI Study , 2006, Current Biology.

[12]  Diane M. Beck,et al.  To See or Not to See: Prestimulus α Phase Predicts Visual Awareness , 2009, The Journal of Neuroscience.

[13]  Sonja Cornelsen,et al.  TMS effects on subjective and objective measures of vision: Stimulation intensity and pre- versus post-stimulus masking , 2011, Consciousness and Cognition.

[14]  K. Nakayama,et al.  Binocular Rivalry and Visual Awareness in Human Extrastriate Cortex , 1998, Neuron.

[15]  N. Logothetis,et al.  Disrupting Parietal Function Prolongs Dominance Durations in Binocular Rivalry , 2010, Current Biology.

[16]  A. Revonsuo,et al.  Timing of the earliest ERP correlate of visual awareness. , 2007, Psychophysiology.

[17]  S Zeki,et al.  The relationship between cortical activation and perception investigated with invisible stimuli , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[18]  H. Lau A higher order Bayesian decision theory of consciousness. , 2008, Progress in brain research.

[19]  M Corbetta,et al.  Frontoparietal cortical networks for directing attention and the eye to visual locations: identical, independent, or overlapping neural systems? , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[20]  R. S. J. Frackowiak,et al.  Human brain activity during spontaneously reversing perception of ambiguous figures , 1998, Proceedings of the Royal Society of London. Series B: Biological Sciences.

[21]  C. Frith,et al.  A fronto-parietal network for rapid visual information processing: a PET study of sustained attention and working memory , 1996, Neuropsychologia.

[22]  Mika Koivisto,et al.  Event-related brain potential correlates of visual awareness , 2010, Neuroscience & Biobehavioral Reviews.

[23]  M. Posner Attention: the mechanisms of consciousness. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[24]  Philip M. Merikle,et al.  Parallels between Perception without Attention and Perception without Awareness , 1997, Consciousness and Cognition.

[25]  Matthew H. Davis,et al.  Detecting awareness in the vegetative state. , 2006, Science.

[26]  Geraint Rees,et al.  Neural Correlates of Conscious and Unconscious Vision in Parietal Extinction , 2002, Neurocase.

[27]  G. Tononi An information integration theory of consciousness , 2004, BMC Neuroscience.

[28]  Randolph Blake,et al.  Psychophysical magic: rendering the visible ‘invisible’ , 2005, Trends in Cognitive Sciences.

[29]  R. Goebel,et al.  Tracking cognitive processes with functional MRI mental chronometry , 2003, Current Opinion in Neurobiology.

[30]  Karl J. Friston,et al.  Dynamic causal modelling , 2003, NeuroImage.

[31]  W. Levelt On binocular rivalry , 1965 .

[32]  Walter Paulus,et al.  Diminution of training-induced transient motor cortex plasticity by weak transcranial direct current stimulation in the human , 2000, Neuroscience Letters.

[33]  Brian N. Pasley,et al.  Subcortical Discrimination of Unperceived Objects during Binocular Rivalry , 2004, Neuron.

[34]  J. Rothwell,et al.  Transcranial magnetic stimulation in cognitive neuroscience – virtual lesion, chronometry, and functional connectivity , 2000, Current Opinion in Neurobiology.

[35]  Rainer Goebel,et al.  Investigating directed cortical interactions in time-resolved fMRI data using vector autoregressive modeling and Granger causality mapping. , 2003, Magnetic resonance imaging.

[36]  Rainer Goebel,et al.  Sustained extrastriate cortical activation without visual awareness revealed by fMRI studies of hemianopic patients , 2001, Vision Research.

[37]  Thomas Metzinger,et al.  Conference on Neural Correlates of Consciousness: Empirical and Conceptual Questions , 1998, Consciousness and Cognition.

[38]  Ian P. Howard,et al.  Binocular Vision and Stereopsis , 1996 .

[39]  S. Dehaene,et al.  Imaging unconscious semantic priming , 1998, Nature.

[40]  J. Driver,et al.  Modulation of visual processing by attention and emotion: windows on causal interactions between human brain regions , 2007, Philosophical Transactions of the Royal Society B: Biological Sciences.

[41]  A. Noë,et al.  A sensorimotor account of vision and visual consciousness. , 2001, The Behavioral and brain sciences.

[42]  E. Thompson,et al.  Are There Neural Correlates of Consciousness , 2004 .

[43]  Charles Wheatstone On some remarkable and hitherto unobserved phenomena of binocular vision. , 1962 .

[44]  M. Hallett Transcranial Magnetic Stimulation: A Primer , 2007, Neuron.

[45]  A Reichenbach,et al.  The cortical site of visual suppression by transcranial magnetic stimulation. , 2007, Cerebral cortex.

[46]  Rainer Goebel,et al.  Mapping directed influence over the brain using Granger causality and fMRI , 2005, NeuroImage.

[47]  D. Kersten,et al.  The representation of perceived angular size in human primary visual cortex , 2006, Nature Neuroscience.

[48]  Po-Jang Hsieh,et al.  “Brain‐reading” of perceived colors reveals a feature mixing mechanism underlying perceptual filling‐in in cortical area V1 , 2010, Human brain mapping.

[49]  Tony Ro,et al.  Extrageniculate mediation of unconscious vision in transcranial magnetic stimulation-induced blindsight. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[50]  Timo Krings,et al.  Cerebral processing of spontaneous reversals of the rotating Necker cube , 2007, Neuroreport.

[51]  J. Gross,et al.  On the Role of Prestimulus Alpha Rhythms over Occipito-Parietal Areas in Visual Input Regulation: Correlation or Causation? , 2010, The Journal of Neuroscience.

[52]  D. Chalmers The conscious mind: in search of a fundamental theory , 1996 .

[53]  N. Kanwisher,et al.  Recognition alters the spatial pattern of FMRI activation in early retinotopic cortex. , 2010, Journal of neurophysiology.

[54]  C. Frith,et al.  Unconscious activation of visual cortex in the damaged right hemisphere of a parietal patient with extinction. , 2000, Brain : a journal of neurology.

[55]  M. Brass,et al.  Unconscious determinants of free decisions in the human brain , 2008, Nature Neuroscience.

[56]  M. Chun,et al.  The Neural Fate of Consciously Perceived and Missed Events in the Attentional Blink , 2004, Neuron.

[57]  G. Tononi,et al.  Breakdown in cortical effective connectivity during midazolam-induced loss of consciousness , 2010, Proceedings of the National Academy of Sciences.

[58]  Rainer Goebel,et al.  On the functional relevance of frontal cortex for passive and voluntarily controlled bistable vision. , 2011, Cerebral cortex.

[59]  Geraint Rees,et al.  Neural correlates of the contents of visual awareness in humans , 2007, Philosophical Transactions of the Royal Society B: Biological Sciences.

[60]  S. Dehaene,et al.  Towards a cognitive neuroscience of consciousness: basic evidence and a workspace framework , 2001, Cognition.

[61]  C. Koch,et al.  Attention and consciousness: two distinct brain processes , 2007, Trends in Cognitive Sciences.

[62]  C. Wheatstone XVIII. Contributions to the physiology of vision. —Part the first. On some remarkable, and hitherto unobserved, phenomena of binocular vision , 1962, Philosophical Transactions of the Royal Society of London.

[63]  R. Blake © 2001 Kluwer Academic Publishers. Printed in the Netherlands. 5 A Primer on Binocular Rivalry, Including Current Controversies , 2000 .

[64]  Timothy J. Andrews,et al.  Activity in the Fusiform Gyrus Predicts Conscious Perception of Rubin's Vase–Face Illusion , 2002, NeuroImage.

[65]  P. Fox,et al.  Mapping context and content: the BrainMap model , 2002, Nature Reviews Neuroscience.

[66]  G. Rees,et al.  Neural correlates of perceptual rivalry in the human brain. , 1998, Science.

[67]  A. Roebroeck,et al.  FMRI Effective Connectivity and TMS Chronometry: Complementary Accounts of Causality in the Visuospatial Judgment Network , 2009, PloS one.

[68]  R. Dolan,et al.  A subcortical pathway to the right amygdala mediating "unseen" fear. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[69]  E. Vogel,et al.  Word meanings can be accessed but not reported during the attentional blink , 1996, Nature.

[70]  J. Schoffelen,et al.  Prestimulus Oscillatory Activity in the Alpha Band Predicts Visual Discrimination Ability , 2008, The Journal of Neuroscience.

[71]  G. Rees,et al.  Covariation of activity in visual and prefrontal cortex associated with subjective visual perception. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[72]  J B Poline,et al.  Cerebral mechanisms of word masking and unconscious repetition priming , 2001, Nature Neuroscience.

[73]  A. Sack,et al.  Null results in TMS: From absence of evidence to evidence of absence , 2011, Neuroscience & Biobehavioral Reviews.

[74]  F. Fang,et al.  Cortical responses to invisible objects in the human dorsal and ventral pathways , 2005, Nature Neuroscience.

[75]  G. Rees,et al.  The Neural Bases of Multistable Perception , 2022 .

[76]  V. Amassian,et al.  Suppression of visual perception by magnetic coil stimulation of human occipital cortex. , 1989, Electroencephalography and clinical neurophysiology.

[77]  Juha Silvanto,et al.  A re-evaluation of blindsight and the role of striate cortex (V1) in visual awareness , 2008, Neuropsychologia.

[78]  J. Eccles,et al.  Quantum aspects of brain activity and the role of consciousness. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[79]  B. Rossion,et al.  Fixation Patterns During Recognition of Personally Familiar and Unfamiliar Faces , 2010, Front. Psychology.

[80]  Christine Preibisch,et al.  Neural Correlates of Spontaneous Direction Reversals in Ambiguous Apparent Visual Motion , 2001, NeuroImage.

[81]  S. Dehaene,et al.  A direct intracranial record of emotions evoked by subliminal words. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[82]  Christof Koch,et al.  Consciousness and Attention: On Sufficiency and Necessity , 2010, Front. Psychology.

[83]  Rainer Goebel,et al.  Brain Network Dynamics Underlying Visuospatial Judgment: An fMRI Connectivity Study , 2010, Journal of Cognitive Neuroscience.

[84]  Max Velmans,et al.  The Science of Consciousness: Psychological, Neuropsychological and Clinical Reviews , 1996 .

[85]  M. Chun,et al.  Linking Implicit and Explicit Memory: Common Encoding Factors and Shared Representations , 2006, Neuron.

[86]  G. Tononi,et al.  Breakdown of Cortical Effective Connectivity During Sleep , 2005, Science.

[87]  C. Koch The quest for consciousness : a neurobiological approach , 2004 .

[88]  Juha Silvanto,et al.  Double dissociation of V1 and V5/MT activity in visual awareness. , 2005, Cerebral cortex.

[89]  R. VanRullen,et al.  The Phase of Ongoing EEG Oscillations Predicts Visual Perception , 2009, The Journal of Neuroscience.

[90]  Axel Cleeremans Computational correlates of consciousness. , 2005, Progress in brain research.

[91]  Andrew B. Leber,et al.  Neural predictors of moment-to-moment fluctuations in cognitive flexibility , 2008, Proceedings of the National Academy of Sciences.