Anti-Inflammatory Effect of Nicavet-2500 in Rodent Models of Acute Inflammation

This study examines the influence of the tissue preparation "NICAVET 2500" on an organism of mammals with use of rodent models of acute inflammation. It is established that action of a preparation leads to decrease in ESR. Hematologic and biochemical parameters also testify to anti-inflammatory action of "NICAVET 2500". Results of histological and morphometric research of a spleen and a thymus show processes of proliferation and migration of immunocytes, testifying to activization of immune reactions. In a thymus of rats of experimental group in comparison with control an increase in the dimensions of thymic lobules and also an increase in quantity of Hassal's bodies, testifying to intensification of synthesis of the thymic hormones participating in process of an immunopoesis are revealed. As a result of the use of the preparation an increase of ability of an organism to resist alteration and also essential decrease in a level of development of inflammatory reaction of an organism are observed. The conducted research demonstrates the expressed immunomodulatory action of a preparation "NICAVET 2500" at an experimental model of inflammation.

[1]  B. Brüne,et al.  Apoptotic Diminution of Immature Single and Double Positive Thymocyte Subpopulations Contributes to Thymus Involution During Murine Polymicrobial Sepsis , 2017, Shock.

[2]  A. Sharara,et al.  Systematic Review and Meta-analysis: Adalimumab Monotherapy Versus Combination Therapy with Immunomodulators for Induction and Maintenance of Remission and Response in Patients with Crohn's Disease , 2017, Inflammatory bowel diseases.

[3]  S. Kang,et al.  Reduction of Asthmatic Parameters by Sea Hare Hydrolysates in a Mouse Model of Allergic Asthma , 2017, Nutrients.

[4]  C. Ponsioen,et al.  Suppression of anti‐drug antibodies to infliximab or adalimumab with the addition of an immunomodulator in patients with inflammatory bowel disease , 2017, Alimentary pharmacology & therapeutics.

[5]  N. Fedosova,et al.  Anticancer effect and immunologic response to xenogeneic embryonic proteins in mice bearing Ehrlich solid carcinoma. , 2017, Experimental oncology.

[6]  E. Azhar,et al.  Evaluation of the Anti-Inflammatory, Antioxidant and Immunomodulatory Effects of the Organic Extract of the Red Sea Marine Sponge Xestospongia testudinaria against Carrageenan Induced Rat Paw Inflammation , 2015, PloS one.

[7]  I. López-Expósito,et al.  Immunomodulatory effects of ovalbumin hydrolysates in a mouse model of food allergy , 2015, Clinical and Translational Allergy.

[8]  L. Eckhart,et al.  Immunolocalization of Scaffoldin, a Trichohyalin‐Like Protein, in the Epidermis of the Chicken Embryo , 2015, Anatomical record.

[9]  L. Timchenko,et al.  INFLUENCE OF THE TISSUE PREPARATION " NICA-EM " ON MORPHOFUNCTIONAL CONDITION OF A LIVER OF RATS AT NORM AND AT EXPERIMENTAL NON-ALCOHOLIC STEATOHEPATITIS , 2015 .

[10]  B. Morukov,et al.  The human system of immunity under the conditions of 105-day isolation and confinement in artificial environment , 2014, Human Physiology.

[11]  Z. Uni,et al.  Temporal transcriptome analysis of the chicken embryo yolk sac , 2014, BMC Genomics.

[12]  W. Seeger,et al.  Immunomodulation by fish-oil containing lipid emulsions in murine acute respiratory distress syndrome , 2014, Critical Care.

[13]  H. Park,et al.  Immune modulation effect of porcine placenta extracts in weaned the pig. , 2013, Journal of animal science.

[14]  D. Kwon,et al.  Antiresorptive Activity of Bacillus-Fermented Antler Extracts: Inhibition of Osteoclast Differentiation , 2013, Evidence-based complementary and alternative medicine : eCAM.

[15]  V. Kojić,et al.  IN VITRO EVALUATION OF THE IMMUNOMODULATORY AND ANTICARCINOGENIC ACTIVITY OF THE FRESHWATER BRYOZOAN HYALINELLA PUNCTATA METHANOLIC EXTRACT , 2013 .

[16]  Yujie Su,et al.  Chicken embryo extracts enhance spleen lymphocyte and peritoneal macrophages function. , 2012, Journal of ethnopharmacology.

[17]  F. Mutinelli,et al.  Evaluation of thymus morphology and serum cortisol concentration as indirect biomarkers to detect low-dose dexamethasone illegal treatment in beef cattle , 2012, BMC Veterinary Research.

[18]  R. He,et al.  Bioactivities of chicken essence. , 2012, Journal of food science.

[19]  A. Nakata.  Psychosocial job stress and immunity: a systematic review. , 2012, Methods in molecular biology.

[20]  D. Bandawane,et al.  IMMUNOMODULATORS: A PHARMACOLOGICAL REVIEW , 2012 .

[21]  K. Jha,et al.  AN OVERVIEW ON IMMUNOMODULATION , 2012 .

[22]  Y. Oh,et al.  Topical application of porcine placenta extract inhibits the progression of experimental contact hypersensitivity. , 2011, Journal of ethnopharmacology.

[23]  F. Spada,et al.  Thymus atrophy and regeneration following dexamethasone administration to beef cattle , 2010, Veterinary Record.

[24]  L. Wagar,et al.  Immunomodulatory properties of fermented soy and dairy milks prepared with lactic acid bacteria. , 2009, Journal of food science.

[25]  Y. Mine,et al.  Immunomodulatory effects of egg white enzymatic hydrolysates containing immunodominant epitopes in a BALB/c mouse model of egg allergy. , 2009, Journal of agricultural and food chemistry.

[26]  W. Hong,et al.  Effects of goat placental immunoregulatory factor on non-specific immunity of mice. , 2009 .

[27]  B. Miniscalco,et al.  Effects of anabolic and therapeutic doses of dexamethasone on thymus morphology and apoptosis in veal calves , 2008, Veterinary Record.

[28]  G. Sempowski,et al.  Cytokines, leptin, and stress‐induced thymic atrophy , 2008, Journal of leukocyte biology.

[29]  K. Hirokawa,et al.  Assessment of Age-related Decline of Immunological Function and Possible Methods for Immunological Restoration in Elderly , 2008, Handbook on Immunosenescence.

[30]  R. Bals,et al.  Journal of Occupational Medicine and Toxicology Interaction of Allergic Airway Inflammation and Innate Immunity: Hygiene and Beyond , 2008 .

[31]  C. Rao,et al.  Evaluation of anti-inflammatory activity of Cissampelos pareira root in rats. , 2007, Journal of ethnopharmacology.

[32]  K. Yamauchi,et al.  Bovine lactoferrin: benefits and mechanism of action against infections. , 2006, Biochemistry and cell biology = Biochimie et biologie cellulaire.

[33]  Y. Mine,et al.  Advances in the value of eggs and egg components for human health. , 2005, Journal of agricultural and food chemistry.

[34]  M. Dacasto,et al.  Effects of low-dose dexamethasone on thymus morphology and immunological parameters in veal calves. , 2005, Journal of veterinary medicine. A, Physiology, pathology, clinical medicine.

[35]  M. Labro.  ' ' Immuno-Fairy Tales ' ' ? Phagocyte Functions : Immunomodulation Interference of Antibacterial Agents with , 2000 .

[36]  L. Cacciatore,et al.  Recovery of low thymic hormone levels in cancer patients by lysine-arginine combination. , 1990, International journal of immunopharmacology.

[37]  G. Markelonis,et al.  Dependence of in vitro myogenesis on a trophic protein present in chicken embryo extract. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[38]  C A WINTER,et al.  Carrageenin-Induced Edema in Hind Paw of the Rat as an Assay for Antiinflammatory Drugs , 1962, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.