Does depth of anesthesia monitoring improve postoperative outcomes?

Purpose of review Devices using the electroencephalogram to estimate anesthetic depth have been available since 1996. Despite the use of these monitors for over a decade, there is little agreement among clinicians about the need for or value of depth of anesthesia monitoring. Since the majority of the studies evaluating the impact of depth of anesthesia monitoring on postoperative outcomes have utilized the bispectral index (BIS Covidian), this manuscript will focus on studies with this device. This review will evaluate the evidence that BIS monitoring can improve long-term outcomes. Recent findings BIS-guided anesthesia can reduce the incidence of awareness with recall in high-risk patients, but a recent study found that anesthetic management directed by an end-tidal anesthetic-agent concentration protocol is equally effective, and probably less expensive. Deep anesthesia (BIS < 45) during the intraoperative period is associated with increased postoperative mortality, but this relationship may be an epiphenomenon rather than causal. Summary There is growing concern that anesthetic management and even specific anesthetic agents may worsen outcomes in high-risk patients. There is, however, no conclusive evidence that depth of anesthesia monitors can improve outcomes and no evidenced-based reasons for anesthesia providers to change their current practice.

[1]  G. Mashour,et al.  Intraoperative awareness: from neurobiology to clinical practice. , 2011, Anesthesiology.

[2]  M. Kertai,et al.  Bispectral Index Monitoring, Duration of Bispectral Index Below 45, Patient Risk Factors, and Intermediate-term Mortality after Noncardiac Surgery in the B-Unaware Trial , 2011, Anesthesiology.

[3]  S. Deem,et al.  B-Aware:recall of intra-operative events , 2004, The Lancet.

[4]  N. Cohen Anesthetic Depth Is Not (Yet) a Predictor of Mortality! , 2005, Anesthesia and analgesia.

[5]  C. Lennmarken,et al.  Reduction in the incidence of awareness using BIS monitoring , 2004, Acta anaesthesiologica Scandinavica.

[6]  Barbara H. Lang,et al.  Epidemiology of Anesthesia-related Mortality in the United States, 1999–2005 , 2009, Anesthesiology.

[7]  J. Olney,et al.  Early Exposure to Common Anesthetic Agents Causes Widespread Neurodegeneration in the Developing Rat Brain and Persistent Learning Deficits , 2003, The Journal of Neuroscience.

[8]  J. Sigl,et al.  Anesthesia awareness and the bispectral index. , 2008, The New England journal of medicine.

[9]  Andrew Forbes,et al.  The Effect of Bispectral Index Monitoring on Long-Term Survival in the B-Aware Trial , 2010, Anesthesia and analgesia.

[10]  Y. Punjasawadwong,et al.  Bispectral index for improving anaesthetic delivery and postoperative recovery. , 2007, The Cochrane database of systematic reviews.

[11]  K. Leslie,et al.  For Personal Use. Only Reproduce with Permission from the Lancet , 2022 .

[12]  C. Kalkman,et al.  Pick up the pieces: depth of anesthesia and long-term mortality. , 2011, Anesthesiology.

[13]  G. Crosby General anesthesia--minding the mind during surgery. , 2011, The New England journal of medicine.

[14]  J. Drummond,et al.  Editorial Board reproached for publication of BIS-mortality correlation. , 2005, Anesthesia and analgesia.

[15]  Fredrik Granath,et al.  Mortality Within 2 Years After Surgery in Relation to Low Intraoperative Bispectral Index Values and Preexisting Malignant Disease , 2009, Anesthesia and analgesia.

[16]  T. Monk,et al.  Anesthetic depth is a predictor of mortality: it's time to take the next step. , 2010, Anesthesiology.

[17]  Jeffrey C. Sigl,et al.  Anesthetic Management and One-Year Mortality After Noncardiac Surgery , 2005, Anesthesia and analgesia.

[18]  M. Eckenhoff,et al.  Inhaled Anesthetic Enhancement of Amyloid-&bgr; Oligomerization and Cytotoxicity , 2004, Anesthesiology.

[19]  Karen B. Domino,et al.  The Incidence of Awareness During Anesthesia: A Multicenter United States Study , 2004, Anesthesia and analgesia.

[20]  C. Lennmarken,et al.  Awareness during anaesthesia: a prospective case study , 2000, The Lancet.

[21]  B. Palanca,et al.  Association of Perioperative Risk Factors and Cumulative Duration of Low Bispectral Index with Intermediate-term Mortality after Cardiac Surgery in the B-Unaware Trial , 2010, Anesthesiology.

[22]  M. Todd,et al.  Practice Advisory for Intraoperative Awareness and Brain Function Monitoring: A Report by the American Society of Anesthesiologists Task Force on Intraoperative Awareness , 2006, Anesthesiology.