Genes for Psychosis and Creativity

Why are genetic polymorphisms related to severe mental disorders retained in the gene pool of a population? A possible answer is that these genetic variations may have a positive impact on psychological functions. Here, I show that a biologically relevant polymorphism of the promoter region of the neuregulin 1 gene (SNP8NRG243177/rs6994992) is associated with creativity in people with high intellectual and academic performance. Intriguingly, the highest creative achievements and creative-thinking scores were found in people who carried the TIT genotype, which was previously shown to be related to psychosis risk and altered prefrontal activation.

[1]  A. Dietrich,et al.  The cognitive neuroscience of creativity , 2004, Psychonomic bulletin & review.

[2]  Jordan B. Peterson,et al.  PERSONALITY PROCESSES AND INDIVIDUAL DIFFERENCES Decreased Latent Inhibition Is Associated With Increased Creative Achievement in High-Functioning Individuals , 2003 .

[3]  R. Lubow,et al.  Are high-schizotypal normal participants distractible or limited in attentional resources? A study of latent inhibition as a function of masking task load and schizotypy level. , 1998, Journal of abnormal psychology.

[4]  Heather C Whalley,et al.  A neuregulin 1 variant associated with abnormal cortical function and psychotic symptoms , 2006, Nature Neuroscience.

[5]  M. Wolf,et al.  Measuring Socioeconomic Status , 2002, Assessment.

[6]  Jordan B. Peterson,et al.  Reliability, Validity, and Factor Structure of the Creative Achievement Questionnaire , 2005 .

[7]  J. Repper.  Schizophrenia: The Positive Perspective , 1998 .

[8]  Costas N. Stefanis,et al.  Impact of Schizophrenia Candidate Genes on Schizotypy and Cognitive Endophenotypes at the Population Level , 2007, Biological Psychiatry.

[9]  M. First,et al.  Structured clinical interview for DSM-IV axis I disorders : SCID-I: clinical version : administration booklet , 1996 .

[10]  J. Schildkraut,et al.  Eminent Creativity, Everyday Creativity, and Health , 1999, American Journal of Psychiatry.

[11]  Paul J. Harrison,et al.  Neuregulin 1 and Schizophrenia: Genetics, Gene Expression, and Neurobiology , 2006, Biological Psychiatry.

[12]  Paul J. Harrison,et al.  Molecular Cloning of a Brain-specific, Developmentally Regulated Neuregulin 1 (NRG1) Isoform and Identification of a Functional Promoter Variant Associated with Schizophrenia*♦ , 2007, Journal of Biological Chemistry.

[13]  A. Raine.  The SPQ: a scale for the assessment of schizotypal personality based on DSM-III-R criteria. , 1991, Schizophrenia bulletin.

[14]  J. Brod.  Creativity and schizotypy , 1997 .

[15]  A M McIntosh,et al.  The effects of a neuregulin 1 variant on white matter density and integrity , 2008, Molecular Psychiatry.

[16]  S. Kéri,et al.  A polymorphism of the neuregulin 1 gene (SNP8NRG243177/rs6994992) affects reactivity to expressed emotion in schizophrenia , 2009, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[17]  Daniel R. Weinberger,et al.  Neuregulin 1 Transcripts Are Differentially Expressed in Schizophrenia and Regulated by 5′ SNPs Associated With the Disease , 2006 .

[18]  B. Miller,et al.  Unravelling Boléro: progressive aphasia, transmodal creativity and the right posterior neocortex. , 2008, Brain : a journal of neurology.