Signal detection for vaccine side effects that have not been specified in advance

An information‐theoretic definition of similarity proposed by Dekang Lin in 1998 appears to have attractive properties for identifying medically similar cases in a large database. Examination of similar cases that appear following vaccination may provide a way of detecting previously unexpected associations. A key element here is the inclusion of shared time‐since‐vaccination as a dimension of similarity while considering concordance on many other features. The system is potentially much more sensitive to patterns with multiple features than are very large, high‐dimension contingency tables. Copyright © 2009 John Wiley & Sons, Ltd.

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