Direct digital sensing of protein biomarkers in solution
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William E. Arter | D. Klenerman | S. Alberti | Titus M. Franzmann | T. Knowles | G. Krainer | R. Owens | P. Challa | Quentin A. E. Peter | K. Saar | Magdalena A Czekalska | Magdalena A. Czekalska | Timothy J. Welsh | Akhila K. Jayaram | R. Jacquat | Christopher G. Taylor | W.C. Traberg | A. Pujari | Lize-Mari van der Linden
[1] Nicolas L. Fawzi,et al. The oncogenic transcription factor FUS-CHOP can undergo nuclear liquid-liquid phase separation. , 2021, Journal of cell science.
[2] S. Chakrabortty,et al. Exosome-based liquid biopsies in cancer: opportunities and challenges , 2021, Annals of oncology : official journal of the European Society for Medical Oncology.
[3] E. Dolgin. Drug startups coalesce around condensates , 2021, Nature Biotechnology.
[4] Patrick M. McCall,et al. Label-free composition determination for biomolecular condensates with an arbitrarily large number of components , 2020, bioRxiv.
[5] William E. Arter,et al. Rapid Structural, Kinetic, and Immunochemical Analysis of Alpha-Synuclein Oligomers in Solution. , 2020, Nano letters.
[6] Y. Im,et al. Cytokine profiling in serum-derived exosomes isolated by different methods , 2020, Scientific Reports.
[7] M. Berezovski,et al. The proteomic analysis of breast cell line exosomes reveals disease patterns and potential biomarkers , 2020, Scientific Reports.
[8] Y. Tao,et al. Exosomes: key players in cancer and potential therapeutic strategy , 2020, Signal Transduction and Targeted Therapy.
[9] Shu Zheng,et al. Application of exosomes as liquid biopsy in clinical diagnosis , 2020, Signal Transduction and Targeted Therapy.
[10] S. Devenish,et al. Multidimensional protein characterisation using microfluidic post-column analysis. , 2020, Lab on a chip.
[11] Jerelle A. Joseph,et al. Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions , 2020, Nature Communications.
[12] Jerelle A. Joseph,et al. Surface electrostatics govern the emulsion stability of biomolecular condensates , 2020, bioRxiv.
[13] William E. Arter,et al. Digital Sensing and Molecular Computation by an Enzyme-Free DNA Circuit. , 2020, ACS nano.
[14] Tuomas P J Knowles,et al. Microfluidic approaches for the analysis of protein–protein interactions in solution , 2020, Biophysical Reviews.
[15] R. Pappu,et al. RNA-Induced Conformational Switching and Clustering of G3BP Drive Stress Granule Assembly by Condensation , 2020, Cell.
[16] Raghu Kalluri,et al. The biology, function, and biomedical applications of exosomes , 2020, Science.
[17] A. Šarić,et al. Dynamics of oligomer populations formed during the aggregation of Alzheimer’s Aβ42 peptide , 2020, bioRxiv.
[18] Min Wu,et al. Applications of genome editing technology in the targeted therapy of human diseases: mechanisms, advances and prospects , 2020, Signal Transduction and Targeted Therapy.
[19] Han-Joon Kim,et al. Immunotherapy Targeting Neurodegenerative Proteinopathies: α-Synucleinopathies and Tauopathies , 2019, Journal of movement disorders.
[20] Maya A. Wright,et al. Analysis of αB-crystallin polydispersity in solution through native microfluidic electrophoresis. , 2019, The Analyst.
[21] T. Knowles,et al. Rapid two-dimensional characterisation of proteins in solution , 2019, Microsystems & Nanoengineering.
[22] T. Knowles,et al. Rapid two-dimensional characterisation of proteins in solution , 2019, Microsystems & Nanoengineering.
[23] Paolo Eusebi,et al. CSF and blood biomarkers for Parkinson's disease , 2019, The Lancet Neurology.
[24] Chuanhao Tang,et al. Aptamer-based fluorescence polarization assay for separation-free exosome quantification. , 2019, Nanoscale.
[25] Asher Mullard. Biomolecular condensates pique drug discovery curiosity , 2019, Nature Reviews Drug Discovery.
[26] T. Knowles,et al. Quaternization of Vinyl/Alkynyl Pyridine Enables Ultrafast Cysteine‐Selective Protein Modification and Charge Modulation , 2019, Angewandte Chemie.
[27] Hilary Graham,et al. The genesis and evolution of bead-based multiplexing. , 2019, Methods.
[28] N. Kosaka,et al. Exploiting the message from cancer: the diagnostic value of extracellular vesicles for clinical applications , 2019, Experimental & Molecular Medicine.
[29] D. Drechsel,et al. FlexiBAC: a versatile, open-source baculovirus vector system for protein expression, secretion, and proteolytic processing , 2018, bioRxiv.
[30] K. Lindorff-Larsen,et al. Cancer Mutations of the Tumor Suppressor SPOP Disrupt the Formation of Active, Phase-Separated Compartments. , 2018, Molecular cell.
[31] C. Deber,et al. A minimal helical-hairpin motif provides molecular-level insights into misfolding and pharmacological rescue of CFTR , 2018, Communications Biology.
[32] William E. Arter,et al. Combining Affinity Selection and Specific Ion Mobility for Microchip Protein Sensing. , 2018, Analytical chemistry.
[33] T. Knowles,et al. Enhancing the Resolution of Micro Free Flow Electrophoresis through Spatially Controlled Sample Injection. , 2018, Analytical chemistry.
[34] P. Tomançak,et al. RNA buffers the phase separation behavior of prion-like RNA binding proteins , 2018, Science.
[35] G. Sobue,et al. Importance of Functional Loss of FUS in FTLD/ALS , 2018, Front. Mol. Biosci..
[36] C. Dobson,et al. Microfluidic approaches for probing amyloid assembly and behaviour. , 2018, Lab on a chip.
[37] E. Peyrin,et al. Panoply of Fluorescence Polarization/Anisotropy Signaling Mechanisms for Functional Nucleic Acid-Based Sensing Platforms. , 2018, Analytical chemistry.
[38] Zhibin Li,et al. Protein Profiling and Sizing of Extracellular Vesicles from Colorectal Cancer Patients via Flow Cytometry. , 2018, ACS nano.
[39] Jie Li,et al. Recent Advances in SELEX Technology and Aptamer Applications in Biomedicine , 2017, International journal of molecular sciences.
[40] C. Brangwynne,et al. Liquid phase condensation in cell physiology and disease , 2017, Science.
[41] A. Deniz,et al. Reentrant Phase Transition Drives Dynamic Substructure Formation in Ribonucleoprotein Droplets. , 2017, Angewandte Chemie.
[42] V. Skvortsova,et al. The FUS protein: Physiological functions and a role in amyotrophic lateral sclerosis , 2017, Molecular Biology.
[43] Anthony A. Hyman,et al. Biomolecular condensates: organizers of cellular biochemistry , 2017, Nature Reviews Molecular Cell Biology.
[44] T. Knowles,et al. Microfluidic devices fabricated using fast wafer-scale LED-lithography patterning. , 2017, Biomicrofluidics.
[45] M. Ingelsson. Alpha-Synuclein Oligomers—Neurotoxic Molecules in Parkinson's Disease and Other Lewy Body Disorders , 2016, Front. Neurosci..
[46] M. Schlierf,et al. farFRET: Extending the Range in Single-Molecule FRET Experiments Beyond 10 nm , 2016 .
[47] Claire H. Michel,et al. ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function , 2015, Neuron.
[48] A. Sauer-Budge,et al. Development of an automated on-chip bead-based ELISA platform. , 2015, Analytical methods : advancing methods and applications.
[49] Marco Y. Hein,et al. A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation , 2015, Cell.
[50] Andreas Hartmann,et al. farFRET: Extending the Range in Single-Molecule FRET Experiments beyond 10 nm. , 2015, Nano letters.
[51] C. Dobson,et al. Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation , 2015, Proceedings of the National Academy of Sciences.
[52] J P Landry,et al. Measuring affinity constants of 1450 monoclonal antibodies to peptide targets with a microarray-based label-free assay platform. , 2015, Journal of immunological methods.
[53] Mehmet Toner,et al. Advancing the speed, sensitivity and accuracy of biomolecular detection using multi-length-scale engineering. , 2014, Nature nanotechnology.
[54] Michele Vendruscolo,et al. Solution conditions determine the relative importance of nucleation and growth processes in α-synuclein aggregation , 2014, Proceedings of the National Academy of Sciences.
[55] Larry Gold,et al. Beyond antibodies: New affinity reagents to unlock the proteome , 2014, Proteomics.
[56] Alexander K. Buell,et al. The role of stable α-synuclein oligomers in the molecular events underlying amyloid formation. , 2014, Journal of the American Chemical Society.
[57] Aaron M. Streets,et al. Microfluidics for biological measurements with single-molecule resolution. , 2014, Current opinion in biotechnology.
[58] Benjamin Schuler,et al. Microfluidic mixer designed for performing single-molecule kinetics with confocal detection on timescales from milliseconds to minutes , 2013, Nature Protocols.
[59] Rohan T Ranasinghe,et al. Ultrarapid generation of femtoliter microfluidic droplets for single-molecule-counting immunoassays. , 2013, ACS nano.
[60] Robert Wilson,et al. Sensitivity and specificity: twin goals of proteomics assays. Can they be combined? , 2013, Expert review of proteomics.
[61] Molly M Stevens,et al. Plasmonic ELISA for the ultrasensitive detection of disease biomarkers with the naked eye. , 2012, Nature nanotechnology.
[62] K. Ikebukuro,et al. Selection of DNA aptamers that recognize α-synuclein oligomers using a competitive screening method. , 2012, Analytical chemistry.
[63] D. Xing,et al. One-step homogeneous protein detection based on aptamer probe and fluorescence cross-correlation spectroscopy. , 2011, Analytical chemistry.
[64] Ron R Lin,et al. High-throughput single-molecule optofluidic analysis , 2011, Nature Methods.
[65] Dieter Braun,et al. Protein-binding assays in biological liquids using microscale thermophoresis. , 2010, Nature communications.
[66] Nam-Trung Nguyen,et al. Oxygen plasma treatment for reducing hydrophobicity of a sealed polydimethylsiloxane microchannel. , 2010, Biomicrofluidics.
[67] Monique A J van Eijndhoven,et al. Exosomes , 2010, Annual review of biochemistry.
[68] Tracy R. Keeney,et al. Aptamer-based multiplexed proteomic technology for biomarker discovery , 2010, PloS one.
[69] David M. Rissin,et al. Single-Molecule enzyme-linked immunosorbent assay detects serum proteins at subfemtomolar concentrations , 2010, Nature Biotechnology.
[70] Ryan T. Turgeon,et al. Measuring aptamer equilibria using gradient micro free flow electrophoresis. , 2010, Analytical chemistry.
[71] Chao Li,et al. A nanoelectronic enzyme-linked immunosorbent assay for detection of proteins in physiological solutions. , 2010, Small.
[72] Chad A. Mirkin,et al. Drivers of biodiagnostic development , 2009, Nature.
[73] Jennifer L. Osborn,et al. Direct multiplexed measurement of gene expression with color-coded probe pairs , 2008, Nature Biotechnology.
[74] Pieter C Dorrestein,et al. A monovalent streptavidin with a single femtomolar biotin binding site , 2006, Nature Methods.
[75] R. Lequin. Enzyme immunoassay (EIA)/enzyme-linked immunosorbent assay (ELISA). , 2005, Clinical chemistry.
[76] S. Holland,et al. Hyper‐IgE syndromes , 2005, Immunological reviews.
[77] V. Subramaniam,et al. Dependence of α-synuclein aggregate morphology on solution conditions , 2002 .
[78] Laurence Zitvogel,et al. Exosomes: composition, biogenesis and function , 2002, Nature Reviews Immunology.
[79] C. Orvain,et al. Identification of an RNA Binding Specificity for the Potential Splicing Factor TLS* , 2001, The Journal of Biological Chemistry.
[80] Andreas Volkmer,et al. Identification of Single Molecules in Aqueous Solution by Time-Resolved Fluorescence Anisotropy , 1999 .
[81] G. Whitesides,et al. Rapid Prototyping of Microfluidic Systems in Poly(dimethylsiloxane). , 1998, Analytical chemistry.
[82] R. Kennedy,et al. Aptamers as ligands in affinity probe capillary electrophoresis. , 1998, Analytical chemistry.
[83] Christian Eggeling,et al. Quantitative identification of different single molecules by selective time-resolved confocal fluorescence spectroscopy. , 1998 .
[84] Richard A. Keller,et al. Molecular Shot Noise, Burst Size Distribution, and Single-Molecule Detection in Fluid Flow: Effects of Multiple Occupancy , 1998 .
[85] J. Kinet,et al. High-affinity oligonucleotide ligands to human IgE inhibit binding to Fc epsilon receptor I. , 1996, Journal of immunology.
[86] C R Cantor,et al. Immuno-PCR: very sensitive antigen detection by means of specific antibody-DNA conjugates. , 1992, Science.
[87] J. Szostak,et al. In vitro selection of RNA molecules that bind specific ligands , 1990, Nature.
[88] L. Gold,et al. Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. , 1990, Science.
[89] E. Engvall,et al. Enzyme-linked immunosorbent assay (ELISA). Quantitative assay of immunoglobulin G. , 1971, Immunochemistry.
[90] K. Ishizaka,et al. Clinical aspects of IgE myeloma. , 1969, The New England journal of medicine.
[91] S. Linse,et al. On-chip label-free protein analysis with downstream electrodes for direct removal of electrolysis products. , 2017, Lab on a chip.
[92] Marystela Ferreira,et al. Surface Plasmon Resonance (SPR) for Sensors and Biosensors , 2017 .
[93] David Wild,et al. The immunoassay handbook : theory and applications of ligand binding, ELISA and related techniques , 2013 .
[94] M. Goedert,et al. Synucleinopathies and Tauopathies , 2012 .
[95] S. Lipkowitz,et al. Triple negative breast cancer cell lines: one tool in the search for better treatment of triple negative breast cancer. , 2010, Breast disease.
[96] A. Alavi,et al. Opportunities and Challenges , 1998, In Vitro Diagnostic Industry in China.