Biliary cirrhosis following the administration of methyltestosterone.

For a prolonged time a patient self-administered a vitamin preparation containing methyltestosterone and concurrently primary biliary cirrhosis developed which caused her death. There is evidence indicating that methyltestosterone and chemically related drugs may play a role in the pathogenesis of primary biliary cirrhosis.

[1]  H. Popper,et al.  Morphologic studies of cholestasis. , 1959, Gastroenterology.

[2]  C. S. Davidson,et al.  Hepatic effects of oral contraceptives. , 1967, The New England journal of medicine.

[3]  A. Kappas Estrogens and the liver. , 1967, Gastroenterology.

[4]  B. Combes,et al.  Biliary cirrhosis induced by chlorpromazine. , 1966, Gastroenterology.

[5]  R. B. Goudie,et al.  Serological and histological diagnosis of primary biliary cirrhosis , 1966, Journal of Clinical Pathology.

[6]  G. Gordan,et al.  METHYLTESTOSTERONE, RELATED STEROIDS, AND LIVER FUNCTION. , 1965, Archives of internal medicine.

[7]  H. Popper,et al.  IMMUNOCYTOCHEMICAL AND SEROLOGIC OBSERVATIONS IN PRIMARY BILIARY CIRRHOSIS. , 1964, The New England journal of medicine.

[8]  R. Bahn,et al.  THE PATHOLOGY OF PRIMARY BILIARY CIRRHOSIS WITH EMPHASIS ON HISTOGENESIS. , 1964, American journal of clinical pathology.

[9]  H. Popper,et al.  The problem of primary biliary cirrhosis. , 1962, The American journal of medicine.

[10]  J. Hamilton The pathology of primary biliary cirrhosis. , 1959, Laboratory investigation; a journal of technical methods and pathology.

[11]  Foss Gl,et al.  Oral methyltestosterone and jaundice. , 1959 .

[12]  Lewis Jh,et al.  Xanthomatous biliary cirrhosis following chlorpromazine, with observations indicating overproduction of cholesterol, hyperprothrombinemia, and the development of portal hypertension. , 1957 .

[13]  S. Werner Clinical syndromes associated with gonadal failure in men. , 1947, The American journal of medicine.