Cardiff Crohn's disease jubilee: the incidence over 50 years.

The incidence of Crohn's disease in Cardiff between 1931 and 1985 has been examined using hospital diagnostic indices supplemented in recent years by records from clinicians, and the departments of pathology and radiology. Four hundred and seven new patients were confirmed after all notes had been reviewed. There has been a large increase from 0.18 cases/10(5) of the population per year in the 1930s to current values of 8.3/10(5)/year. The incidence continues to rise and shows an increasing proportion of patients with colorectal disease. Peak age specific incidences occur in the third and eighth decades of life.

[1]  P. Rozen,et al.  Environmental Factors in Inflammatory Bowel Disease1 , 1986 .

[2]  V. Binder,et al.  Epidemiological Data of Chronic Inflammatory Bowel Diseases in the Copenhagen Region , 1986 .

[3]  S. Shapiro,et al.  Evidence for an increased risk of Crohn's disease in oral contraceptive users. , 1985, Gastroenterology.

[4]  J. Mayberry,et al.  Epidemiological aspects of Crohn's disease: a review of the literature. , 1984, Gut.

[5]  J. Rhodes,et al.  Colonic Crohn's disease and use of oral contraception. , 1984, British medical journal.

[6]  W. Grove.  Statistical Methods for Rates and Proportions, 2nd ed , 1981 .

[7]  J Kyle,et al.  Fall in the incidence of Crohn's disease. , 1980, Gut.

[8]  J. Mayberry,et al.  Incidence of Crohn's disease in Cardiff between 1934-1977. , 1979, Gut.

[9]  G. Hellers.  Crohn's disease in Stockholm county 1955-1974. A study of epidemiology, results of surgical treatment and long-term prognosis. , 1979, Acta chirurgica Scandinavica. Supplementum.

[10]  F. Brahme,et al.  Crohn's disease in a defined population. An epidemiological study of incidence, prevalence, mortality, and secular trends in the city of Malmö, Sweden. , 1975, Gastroenterology.

[11]  D. Miller,et al.  Changing patterns in epidemiology of Crohn's disease. , 1974, Lancet.

[12]  J. Fleiss,et al.  Statistical methods for rates and proportions , 1973 .

[13]  J Kyle,et al.  An epidemiological study of Crohn's disease in Northeast Scotland. , 1971, Gastroenterology.

[14]  G. Oppenheimer,et al.  REGIONAL ILEITIS: A PATHOLOGIC AND CLINICAL ENTITY , 1932 .