Animal Models of Alcohol Withdrawal

One diagnostic criterion of alcohol dependence is the appearance of a withdrawal syndrome when alcohol consumption ceases. Researchers have used various animal models, including isolated brain cells, slices of brain tissue, and intact animals, to study the mechanisms and manifestations of withdrawal. Results from these experimental studies have demonstrated that many consequences of withdrawal found in animals resemble those observed in humans. Such signs and symptoms of alcohol withdrawal include enhanced activity of the autonomic nervous system; body posture and motor abnormalities; hyperexcitability of the central nervous system, including sensory hyperreactivity; convulsions; anxiety; and psychological discomfort. Researchers also have used animal models to study the electrophysiological correlates of withdrawal, as well as neurobiological mechanisms underlying alcohol dependence and withdrawal.

[1]  H. Lal,et al.  Effects of ethanol and ethanol withdrawal on nociception in rats. , 1999, Alcoholism, clinical and experimental research.

[2]  H. Becker.  Alcohol Withdrawal: Neuroadaptation and Sensitization , 1999, CNS Spectrums.

[3]  D. Monaghan,et al.  Evidence for a causative role of N-methyl-D-aspartate receptors in an in vitro model of alcohol withdrawal hyperexcitability. , 1998, The Journal of pharmacology and experimental therapeutics.

[4]  F. Crews,et al.  Induction of Fos-like proteins and ultrasonic vocalizations during ethanol withdrawal: further evidence for withdrawal-induced anxiety. , 1998, Alcoholism, clinical and experimental research.

[5]  H. Little,et al.  Comparison of the effects of drugs on hyperexcitability induced in hippocampal slices by withdrawal from chronic ethanol consumption , 1998, British journal of pharmacology.

[6]  J. Crabbe,et al.  Exploring Alcohol Withdrawal Syndrome , 1997, Alcohol health and research world.

[7]  M. Ticku,et al.  Functional characterization of a kindling-like model of ethanol withdrawal in cortical cultured neurons after chronic intermittent ethanol exposure , 1997, Brain Research.

[8]  H. Becker,et al.  Repeated ethanol withdrawal experience increases the severity and duration of subsequent withdrawal seizures in mice. , 1997, Alcohol.

[9]  H. Becker,et al.  The alcohol withdrawal "kindling" phenomenon: clinical and experimental findings. , 1996, Alcoholism, clinical and experimental research.

[10]  N. Kathmann,et al.  ERP changes in alcoholics with and without alcohol psychosis , 1996, Biological Psychiatry.

[11]  L. Veatch,et al.  Repeated ethanol withdrawal produces site-dependent increases in EEG spiking. , 1996, Alcoholism, clinical and experimental research.

[12]  G. Koob,et al.  Time-dependent quantifiable withdrawal from ethanol in the rat: effect of method of dependence induction. , 1996, Alcohol.

[13]  G. Fein,et al.  Delayed P3A in abstinent elderly male chronic alcoholics. , 1995, Alcoholism, clinical and experimental research.

[14]  G. Koob,et al.  Decreased brain reward produced by ethanol withdrawal. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[15]  H. Little,et al.  Identification of distinct components, with different time courses, of the changes in response to convulsive stimuli during ethanol withdrawal. , 1995, The Journal of pharmacology and experimental therapeutics.

[16]  C. Nemeroff,et al.  Neurochemical correlates of sympathetic activation during severe alcohol withdrawal. , 1994, Alcoholism, clinical and experimental research.

[17]  O. Parsons,et al.  Drinking history is related to persistent blood pressure dysregulation in postwithdrawal alcoholics. , 1994, Alcoholism, clinical and experimental research.

[18]  D. Gauvin,et al.  State-dependent stimulus control: cueing attributes of ethanol "hangover" in rats. , 1993, Alcoholism, clinical and experimental research.

[19]  D. Gauvin,et al.  The discriminative stimulus properties of acute ethanol withdrawal (hangover) in rats. , 1992, Alcoholism, clinical and experimental research.

[20]  S. File,et al.  Effects of nitrendipine, chlordiazepoxide, flumazenil and baclofen on the increased anxiety resulting from alcohol withdrawal , 1992, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[21]  J. F. Czachura,et al.  Spontaneous versus elicited seizures following ethanol withdrawal: differential time course. , 1989, Alcohol.

[22]  D. Benjamin,et al.  Characterization of a pentylenetetrazol-like interoceptive stimulus produced by ethanol withdrawal. , 1988, The Journal of pharmacology and experimental therapeutics.

[23]  C. Ehlers.  ERP responses to ethanol and diazepam administration in squirrel monkeys. , 1988, Alcohol.

[24]  R. Anton,et al.  Stereotypic wall climbing in mice during ethanol withdrawal: a new measure of physical dependence. , 1987, Alcohol.

[25]  R. Emmerson,et al.  EEG, visually evoked and event related potentials in young abstinent alcoholics. , 1987, Alcohol.

[26]  L. Pohorecky,et al.  Assessment of the development of tolerance to ethanol using multiple measures. , 1986, Alcoholism, clinical and experimental research.

[27]  M. Hesselbrock,et al.  Power and coherence analysis of the EEG in hospitalized alcoholics and nonalcoholic controls. , 1985, Journal of studies on alcohol.

[28]  G. Breese,et al.  Differential sensitivity of ethanol withdrawal signs in the rat to gamma-aminobutyric acid (GABA)mimetics: blockade of audiogenic seizures but not forelimb tremors. , 1983, The Journal of pharmacology and experimental therapeutics.

[29]  J. Crabbe,et al.  Alcohol Tolerance and Dependence , 1981 .

[30]  D. B. Goldstein.  Relationship of alcohol dose to intensity of withdrawal signs in mice. , 1972, The Journal of pharmacology and experimental therapeutics.

[31]  M. Victor.  The alcohol withdrawal syndrome: theory and practice. , 1970, Postgraduate medicine.

[32]  Clinical Neurology , 1953, Neurology.

[33]  H. Becker.  Kindling in Alcohol Withdrawal , 1998, Alcohol health and research world.

[34]  J. Littleton.  Neurochemical Mechanisms Underlying Alcohol Withdrawal , 1998, Alcohol health and research world.

[35]  R. Saitz.  Introduction to Alcohol Withdrawal , 1998, Alcohol health and research world.

[36]  Bernice Porjesz,et al.  Effects of alcohol on electrophysiological activity of the brain. , 1996 .

[37]  H. Begleiter,et al.  The pharmacology of alcohol and alcohol dependence , 1996 .

[38]  S. Zornetzer,et al.  Alcohol withdrawal in mice: electroencephalographic and behavioral correlates. , 1974, Electroencephalography and clinical neurophysiology.