Behavioral and anatomical deficits in mice homozygous for a modified β-amyloid precursor protein gene

[1]  H. Lipp,et al.  Mice deficient for the glycoprotein show subtle abnormalities in myelin , 1994, Neuron.

[2]  S. Younkin,et al.  An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants. , 1994, Science.

[3]  H. Lipp,et al.  Swimming navigation, open-field activity, and extrapolation behavior of two inbred mouse strains with Robertsonian translocation of chromosomes 8 and 17 , 1994, Behavior genetics.

[4]  D. Small,et al.  A heparin-binding domain in the amyloid protein precursor of Alzheimer's disease is involved in the regulation of neurite outgrowth , 1994, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[5]  H. Lipp,et al.  Hippocampal mossy fibers and swimming navigation in mice: Correlations with size and left‐right asymmetries , 1994, Hippocampus.

[6]  R. Tanzi,et al.  Expression of a ubiquitous, cross-reactive homologue of the mouse beta-amyloid precursor protein (APP). , 1994, The Journal of biological chemistry.

[7]  J. Hardy,et al.  ApoE, amyloid, and Alzheimer's disease. , 1994, Science.

[8]  D. Pollen,et al.  Alzheimer's disease and possible gene interaction. , 1994, Science.

[9]  A. Goate,et al.  Role of the β-amyloid precursor protein in Alzheimer's disease , 1994 .

[10]  D. Kirschner,et al.  Mice deficient for the myelin-associated glycoprotein show subtle abnormalities in myelin. , 1994, Neuron.

[11]  A. Goate,et al.  Role of the beta-amyloid precursor protein in Alzheimer's disease. , 1994, Trends in biochemical sciences.

[12]  D. Selkoe,et al.  Cellular processing of β-amyloid precursor protein and the genesis of amyloid β-peptide , 1993, Cell.

[13]  H. Ruffner,et al.  Induction of type I interferon genes and interferon-inducible genes in embryonal stem cells devoid of interferon regulatory factor 1. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[14]  K. Beyreuther,et al.  Amyloid-like properties of peptides flanking the epitope of amyloid precursor protein-specific monoclonal antibody 22C11. , 1993, The Journal of biological chemistry.

[15]  S. Sorbi.  Molecular genetics of Alzheimer’s disease , 1993, Aging.

[16]  Mark P. Mattson,et al.  β-Amyloid precursor protein metabolites and loss of neuronal Ca2+ homeostasis in Alzheimer's disease , 1993, Trends in Neurosciences.

[17]  D. Selkoe.  Physiological production of the β-amyloid protein and the mechanism of Alzheimer's disease , 1993, Trends in Neurosciences.

[18]  M. Mullan,et al.  Genetics and molecular advances in Alzheimer's disease , 1993, Trends in Neurosciences.

[19]  B. Hyman,et al.  Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions , 1993, Neuron.

[20]  G. Schellenberg,et al.  Apolipoprotein E genotype and Alzheimer's disease , 1993, The Lancet.

[21]  B. Hyman,et al.  Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid β protein precursor , 1993, Nature Genetics.

[22]  J. Haines,et al.  Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. , 1993, Science.

[23]  G. Perry,et al.  Identification and transport of full-length amyloid precursor proteins in rat peripheral nervous system , 1993, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[24]  M. Pericak-Vance,et al.  Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[25]  M. Mattson,et al.  Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the β-amyloid precursor protein , 1993, Neuron.

[26]  S. Younkin,et al.  Release of excess amyloid beta protein from a mutant amyloid beta protein precursor. , 1993, Science.

[27]  F. Crawford,et al.  Genetic and molecular advances in Alzheimer's disease. , 1993, Trends in neurosciences.

[28]  B. Hyman,et al.  Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid beta protein precursor. , 1993, Nature genetics.

[29]  M. Capecchi,et al.  Mice homozygous for a targeted disruption of the proto-oncogene int-2 have developmental defects in the tail and inner ear. , 1993, Development.

[30]  D. Selkoe,et al.  Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production , 1992, Nature.

[31]  T. Tully,et al.  Human amyloid precursor protein ameliorates behavioral deficit of flies deleted for appl gene , 1992, Neuron.

[32]  S. Prusiner,et al.  Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein , 1992, Nature.

[33]  Hans-Peter Lipp,et al.  A new computer program for detailed off-line analysis of swimming navigation in the Morris water maze , 1992, Journal of Neuroscience Methods.

[34]  D. Selkoe,et al.  Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production. , 1992, Nature.

[35]  P. Greengard,et al.  Amyloidogenesis in Alzheimer's disease: some possible therapeutic opportunities. , 1992, Trends in pharmacological sciences.

[36]  C. Masters,et al.  Mechanisms of Amyloid Deposition in Alzheimer's Disease a , 1991, Annals of the New York Academy of Sciences.

[37]  M. Rudnicki,et al.  Simplified mammalian DNA isolation procedure. , 1991, Nucleic acids research.

[38]  H. Lipp,et al.  Swimming navigation and structural variations of the infrapyramidal mossy fibers in the hippocampus of the mouse , 1991, Hippocampus.

[39]  Allan Bradley,et al.  Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice , 1991, Cell.

[40]  Y. Sakaki,et al.  Genomic organization of the human-amyloid beta-protein precursor gene. , 1990, Gene.

[41]  Andrew P. McMahon,et al.  The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain , 1990, Cell.

[42]  J. Wehner,et al.  Hippocampal protein kinase C activity is reduced in poor spatial learners , 1990, Brain Research.

[43]  C. Regan,et al.  Intraventricular infusions of antibodies to amyloid-β-protein precursor impair the acquisition of a passive avoidance response in the rat , 1990, Neuroscience Letters.

[44]  B. Müller-Hill,et al.  Differential splicing of Alzheimer's disease amyloid A4 precursor RNA in rat tissues: PreA4(695) mRNA is predominantly produced in rat and human brain. , 1990, Biochemical and biophysical research communications.

[45]  Y. Sakaki,et al.  Structure and expression of the alternatively-spliced forms of mRNA for the mouse homolog of Alzheimer's disease amyloid beta protein precursor. , 1989, Biochemical and biophysical research communications.

[46]  J. Mitchell,et al.  Absence of corpus callosum. , 1988, Journal of the Tennessee Medical Association.

[47]  Y. Sakaki,et al.  Complementary DNA for the mouse homolog of the human amyloid beta protein precursor. , 1987, Biochemical and biophysical research communications.

[48]  M. Capecchi,et al.  Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells , 1987, Cell.

[49]  M. Yaniv,et al.  Determinants of rat albumin promoter tissue specificity analyzed by an improved transient expression system , 1987, Molecular and cellular biology.

[50]  P. Chomczyński,et al.  Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. , 1987, Analytical biochemistry.

[51]  David W. Melton,et al.  Targetted correction of a mutant HPRT gene in mouse embryonic stem cells , 1987, Nature.

[52]  G. Gennarini,et al.  Studies on the transmembrane disposition of the neural cell adhesion molecule N-CAM. The use of liposome-inserted radioiodinated N-CAM to study its transbilayer orientation. , 1984, European journal of biochemistry.

[53]  R. Morris.  Developments of a water-maze procedure for studying spatial learning in the rat , 1984, Journal of Neuroscience Methods.

[54]  B. Merker,et al.  Technical modifications of gallyas' silver stain for myelin , 1983, Journal of Neuroscience Methods.

[55]  R. Morris,et al.  Place navigation impaired in rats with hippocampal lesions , 1982, Nature.

[56]  F. Gallyas.  Silver staining of myelin by means of physical development. , 1979, Neurological research.

[57]  L. Nadel,et al.  The Hippocampus as a Cognitive Map , 1978 .

[58]  U. K. Laemmli,et al.  Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4 , 1970, Nature.