VEGF: a critical player in neurodegeneration.

VEGF is a prototype angiogenic factor, but recent evidence indicates that this growth factor also has direct effects on neural cells. Abnormal regulation of VEGF expression has now been implicated in several neurodegenerative disorders, including motoneuron degeneration. This has stimulated an increasing interest in assessing the therapeutic potential of VEGF as a neuroprotective agent for such neurodegenerative disorders.

[1]  Steven A. Goldman,et al.  Coordinated Interaction of Neurogenesis and Angiogenesis in the Adult Songbird Brain , 2002, Neuron.

[2]  Alzheimer's disease and angiogenesis , 2003 .

[3]  J. Duffy,et al.  Vasomotor hyporeactivity in the anterior cerebral artery during motor activation in Huntington’s disease patients , 2000, Brain Research.

[4]  R. Vos,et al.  Pathological features of cerebral cortical capillaries are doubled in Alzheimer’s disease and Parkinson’s disease , 2000, Acta Neuropathologica.

[5]  K. Jin,et al.  Vascular endothelial growth factor: direct neuroprotective effect in in vitro ischemia. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[6]  C. Cepko,et al.  Flk-1, a Receptor for Vascular Endothelial Growth Factor (VEGF), Is Expressed by Retinal Progenitor Cells , 1996, The Journal of Neuroscience.

[7]  R. Alderson,et al.  Vascular Endothelial Cell Growth Factors Promote the In Vitro Development of Rat Photoreceptor Cells , 2000, The Journal of Neuroscience.

[8]  D. Gozal,et al.  VEGF-induced activation of the PI3-K/Akt pathway reduces mutant SOD1-mediated motor neuron cell death. , 2003, Brain research. Molecular brain research.

[9]  J. Rosenstein,et al.  Angiogenic and astroglial responses to vascular endothelial growth factor administration in adult rat brain , 2002, Neuroscience.

[10]  M. Viitanen,et al.  CADASIL: a Common Form of Hereditary Arteriopathy Causing Brain Infarcts and Dementia , 2002, Brain pathology.

[11]  K. Jin,et al.  Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[12]  M. Qiu,et al.  Role of vascular endothelial growth factor in neuronal DNA damage and repair in rat brain following a transient cerebral ischemia , 2002, Journal of neuroscience research.

[13]  Lieve Moons,et al.  Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele , 1996, Nature.

[14]  R. Lucius,et al.  Vascular endothelial growth factor induces chemotaxis and proliferation of microglial cells , 2002, Journal of Neuroimmunology.

[15]  Yasuto Itoyama,et al.  Reduction of Ischemic Damage by Application of Vascular Endothelial Growth Factor in Rat Brain after Transient Ischemia , 1998, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[16]  M. Monje,et al.  Irradiation induces neural precursor-cell dysfunction , 2002, Nature Medicine.

[17]  S. Rafii,et al.  Endothelial Trophic Support of Neuronal Production and Recruitment from the Adult Mammalian Subependyma , 1999, Molecular and Cellular Neuroscience.

[18]  J. Isner,et al.  Improvement in chronic ischemic neuropathy after intramuscular phVEGF165 gene transfer in patients with critical limb ischemia. , 2001, Archives of neurology.

[19]  松崎 秀夫 Vascular endothelial growth factor rescues hippocampal neurons from glutamate-induced toxicity : Signal transduction cascades , 2003 .

[20]  T. Palmer,et al.  Vascular niche for adult hippocampal neurogenesis , 2000, The Journal of comparative neurology.

[21]  G. Waldemar,et al.  Focal reductions of cerebral blood flow in amyotrophic lateral sclerosis: A [99m Tc]-d,l-HMPAO SPECT study , 1992, Journal of the Neurological Sciences.

[22]  G. Lundborg,et al.  Vascular endothelial growth factor stimulates Schwann cell invasion and neovascularization of acellular nerve grafts , 1999, Brain Research.

[23]  J. Alroy,et al.  Favorable effect of VEGF gene transfer on ischemic peripheral neuropathy , 2000, Nature Medicine.

[24]  Anders Wallin,et al.  Increased intrathecal levels of the angiogenic factors VEGF and TGF-β in Alzheimer’s disease and vascular dementia , 2002, Neurobiology of Aging.

[25]  H. Budka,et al.  Disease-associated prion protein in vessel walls. , 2002, The American journal of pathology.

[26]  O. Lindvall,et al.  Neurogenesis after ischaemic brain insults , 2003, Current Opinion in Neurobiology.

[27]  J. Isner,et al.  Reversal of experimental diabetic neuropathy by VEGF gene transfer. , 2001, The Journal of clinical investigation.

[28]  Till Acker,et al.  Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration , 2001, Nature Genetics.

[29]  M Chopp,et al.  VEGF enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain. , 2000, The Journal of clinical investigation.

[30]  Zhu Yonghua,et al.  Vascular endothelial growth factor promotes proliferation of cortical neuron precursors by regulating E2F expression , 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[31]  G. Lundborg,et al.  Vascular Endothelial Growth Factor Has Neurotrophic Activity and Stimulates Axonal Outgrowth, Enhancing Cell Survival and Schwann Cell Proliferation in the Peripheral Nervous System , 1999, The Journal of Neuroscience.

[32]  P. Carmeliet,et al.  VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death , 2003, Nature Genetics.

[33]  H. Scharfman,et al.  Vascular endothelial growth factor (VEGF) in seizures: a double-edged sword. , 2004, Advances in experimental medicine and biology.

[34]  V. Arolt,et al.  Vascular Endothelial Growth Factor Protects Cultured Rat Hippocampal Neurons against Hypoxic Injury via an Antiexcitotoxic, Caspase-Independent Mechanism , 2002, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[35]  W. Silverman,et al.  Vascular, glial and neuronal effects of vascular endothelial growth factor in mesencephalic explant cultures , 1999, Neuroscience.

[36]  W. Mali,et al.  Effect of age on cerebral blood flow: measurement with ungated two-dimensional phase-contrast MR angiography in 250 adults. , 1998, Radiology.

[37]  W. Greenough,et al.  Learning causes synaptogenesis, whereas motor activity causes angiogenesis, in cerebellar cortex of adult rats. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[38]  K. Jin,et al.  VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia. , 2003, The Journal of clinical investigation.

[39]  S. Sullivan,et al.  Effects of intraventricular infusion of vascular endothelial growth factor on cerebral blood flow, edema, and infarct volume , 2003, Acta Neurochirurgica.

[40]  S. Kumar,et al.  Role of Angiogenesis in Patients With Cerebral Ischemic Stroke , 1994, Stroke.

[41]  R. Kalaria Small Vessel Disease and Alzheimer’s Dementia: Pathological Considerations , 2002, Cerebrovascular Diseases.

[42]  M. Vitek,et al.  Vascular endothelial growth factor rescues hippocampal neurons from glutamate‐induced toxicity: signal transduction cascades , 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[43]  A. Samii,et al.  Vascular endothelial growth factor expression in peripheral nerves and dorsal root ganglia in diabetic neuropathy in rats , 1999, Neuroscience Letters.

[44]  Jeffrey D. Rothstein,et al.  From charcot to lou gehrig: deciphering selective motor neuron death in als , 2001, Nature Reviews Neuroscience.

[45]  M. Kanje,et al.  Postnatal expression of VEGF and its receptor flk-1 in peripheral ganglia , 2001, Neuroreport.

[46]  Devin K. Binder,et al.  Recent Advances in Epilepsy Research , 2004, Advances in Experimental Medicine and Biology.

[47]  Shigeru Watanabe,et al.  Local cerebral blood flow in motor neuron disease: correlation with clinical findings , 1996, Journal of the Neurological Sciences.

[48]  R. Pallini,et al.  Promotion of regeneration of corticospinal tract axons in rats with recombinant vascular endothelial growth factor alone and combined with adenovirus coding for this factor. , 2002, Journal of neurosurgery.

[49]  N. van Bruggen,et al.  VEGF antagonism reduces edema formation and tissue damage after ischemia/reperfusion injury in the mouse brain. , 1999, The Journal of clinical investigation.

[50]  S. E. Brodie New York, New York, USA , 1996 .

[51]  P. Carmeliet Angiogenesis in health and disease , 2003, Nature Medicine.

[52]  J. Goldman,et al.  Interactions between glial progenitors and blood vessels during early postnatal corticogenesis: Blood vessel contact represents an early stage of astrocyte differentiation , 1997, The Journal of comparative neurology.

[53]  W. Stewart,et al.  Paracrine and Autocrine Functions of Neuronal Vascular Endothelial Growth Factor (VEGF) in the Central Nervous System* , 2002, The Journal of Biological Chemistry.