Mycosis fungoides presenting with extensive pyoderma gangrenosum‐like ulcers

Mycosis fungoides (MF) may present with atypical clinical manifestations. Usually it mimics various chronic dermatoses, with the appearance of ulcers during the tumour stage. Infrequently, cutaneous ulcers are the main or initial sign of lymphoma. We report the case of a man who presented multiple skin lesions that clinically appeared to be pyoderma gangrenosum (PG). However, histological and immunohistochemical examination revealed MF. This case illustrates that PG‐like ulcers may be atypical cutaneous manifestations of MF and exceptionally the presenting sign of this disease.

[1]  D. Carney,et al.  Mycosis fungoides bullosa simulating pyoderma gangrenosum , 2000, The British journal of dermatology.

[2]  C. Meijer,et al.  Primary cutaneous CD8-positive epidermotropic cytotoxic T cell lymphomas. A distinct clinicopathological entity with an aggressive clinical behavior. , 1999, The American journal of pathology.

[3]  H. Kerl,et al.  EORTC classification for primary cutaneous lymphomas: a proposal from the Cutaneous Lymphoma Study Group of the European Organization for Research and Treatment of Cancer. , 1997, Blood.

[4]  A. Lorincz.  Cutaneous T-cell lymphoma (mycosis fungoides) , 1996, The Lancet.

[5]  W. Su,et al.  Pyoderma gangrenosum: classification and management. , 1996, Journal of the American Academy of Dermatology.

[6]  D. Metze,et al.  Perioal eczema as a manifestation of cutaneous T‐cell lymphoma , 1995 .

[7]  D. Metze,et al.  Perioral eczema as a manifestation of cutaneous T-cell lymphoma. , 1995, The British journal of dermatology.

[8]  S. Lakhanpal,et al.  Angiocentric T cell lymphoma masquerading as cutaneous vasculitis. , 1994, The Journal of rheumatology.

[9]  H. Hollema,et al.  Primary cutaneous T‐cell lymphoma: Clinicopathological features and prognostic parameters of 35 cases other than mycosis fungoides and cd30‐positive large cell lymphoma , 1994, The Journal of pathology.

[10]  W. Su,et al.  Malignant lymphoma and leukemia with prominent ulceration: clinicopathologic correlation of 33 cases. , 1992, Journal of the American Academy of Dermatology.

[11]  W. Sterry,et al.  HTLV‐1‐negative pleomorphic T‐cell lymphoma of the skin: the clinicopathological correlations and natural history of 15 patients , 1992, The British journal of dermatology.

[12]  P. Roland,et al.  Pyoderma Gangrenosum with Cutaneous T-Cell Lymphoma Manifested as Lower Extremity Ulcers—Case Reports , 1991, Angiology.

[13]  A. Norins,et al.  Vesicular cutaneous T cell lymphoma presenting with gangrene. , 1990, Journal of the American Academy of Dermatology.

[14]  J. Kartsonis,et al.  Mycosis fungoides bullosa. , 1990, The American Journal of dermatopathology.

[15]  J. Armitage,et al.  Pyoderma gangrenosum or cutaneous lymphoma: a difficult clinical diagnosis. , 1988, Cutis.

[16]  M. Stringer,et al.  The lower limb as a presenting site of malignant lymphoma. , 1987, Annals of the Royal College of Surgeons of England.

[17]  E. F. Sherertz,et al.  Sarcoidal reaction to lymphoma presenting as granulomatous rosacea. , 1986, Archives of dermatology.

[18]  S. Neill,et al.  A case of mycosis fungoides mimicking actinic reticuloid , 1985, The British journal of dermatology.

[19]  M. Rustin,et al.  Hairy cell leukemia and pyoderma gangrenosum. , 1985, Journal of the American Academy of Dermatology.

[20]  H. Haynes,et al.  Neutrophilic dermatosis of myeloproliferative disorders. Atypical forms of pyoderma gangrenosum and Sweet's syndrome associated with myeloproliferative disorders. , 1983, Journal of the American Academy of Dermatology.

[21]  Shelley Wb.  An idiopathic leg ulcer as the presenting sign of lymphoma. , 1981 .

[22]  W. Shelley.  An idiopathic leg ulcer as the presenting sign of lymphoma. , 1981, Cutis.

[23]  Haralampos J. Milionis,et al.  Cutaneous T-cell lymphoma. , 2005, The Journal of dermatologic surgery and oncology.

[24]  I. Sneddon,et al.  Pyoderma gangrenosum complicating non‐Hodgkin's lymphoma , 1980, The British journal of dermatology.

[25]  A. Wahba,et al.  Herpes simplex virus isolation from pyoderma gangrenosum lesions in a patient with chronic lymphatic leukemia. , 1979, Dermatologica.

[26]  C. Tay.  Pyoderma Gangrenosum and Leukemia , 1973 .

[27]  J. Smith,et al.  Generalized perforating granuloma annulare. , 1973, Archives of dermatology.

[28]  H. H. Roenigk,et al.  Mycosis fungoides bullosa. , 1971, Archives of dermatology.