Neural Elements in Human Cervical Intervertebral Discs

This study attempted to characterize neural elements within the human cervical intervertebral disc. Cervical intervertebral discs were obtained from four adult human subjects at autopsy. Discs were stained in bulk with gold chloride, sectioned, and viewed with the light microscope. Nerve fibers appeared to enter the disc in the posterolateral direction and course both parallel and perpendicular to the bundles of the anulus fibrosus. Nerves were seen throughout the anulus but were most numerous in the middle third of the disc. Receptors resembling Pacinian corpuscles and Golgi tendon organs were seen in the posterolateral region of the upper third of the disc. These results provide further evidence that human cervical intervertebral discs are supplied with both nerve fibers and mechanoreceptors.

[1]  J. O'Brien,et al.  The neuropathology of intervertebral discs removed for low‐back pain , 1980, The Journal of pathology.

[2]  O. Hassler,et al.  The human intervertebral disc. A micro-angiographical study on its vascular supply at various ages. , 1969, Acta orthopaedica Scandinavica.

[3]  W. J. Hamilton.  Synovial Joints: Their Structure and Mechanics , 1961 .

[4]  M L Zimny,et al.  Mechanoreceptors in articular tissues. , 1988, The American journal of anatomy.

[5]  D. J. Albright,et al.  Mechanoreceptors in the human medial meniscus. , 1988, Acta anatomica.

[6]  P. G. Roofe.  INNERVATION OF ANNULUS FIBROSUS AND POSTERIOR LONGITUDINAL LIGAMENT: FOURTH AND FIFTH LUMBAR LEVEL , 1940 .

[7]  D. Stilwell.  The nerve supply of the vertebral column and its associated structures in the monkey , 1956, The Anatomical record.

[8]  N. Bogduk,et al.  The Innervation of the Cervical Intervertebral Discs , 1988, Spine.

[9]  B. Wyke.  The neurological basis of thoracic spinal pain. , 1970, Rheumatology and physical medicine.

[10]  C. Barnett.  Synovial joints : their structure and mechanics , 1961 .

[11]  B. O'connor,et al.  The structure and innervation of cat knee menisci, and their relation to a "sensory hypothesis" of meniscal function. , 1978, The American journal of anatomy.

[12]  B. Wyke,et al.  The innervation of the knee joint. An anatomical and histological study in the cat. , 1967, Journal of anatomy.

[13]  S. Skoglund.  Anatomical and physiological studies of knee joint innervation in the cat. , 1956, Acta physiologica Scandinavica. Supplementum.

[14]  N. Bogduk,et al.  The nerve supply to the human lumbar intervertebral discs. , 1981, Journal of anatomy.

[15]  F. G. Evans,et al.  Strength of biological materials , 1970 .

[16]  T. Sisk,et al.  The mechanoreceptor innervation of the human fibular collateral ligament. , 1989, Journal of anatomy.

[17]  B. Vernon‐roberts,et al.  Degenerative changes in the intervertebral discs of the lumbar spine and their sequelae. , 1977, Rheumatology and rehabilitation.

[18]  E. Gardner.  The distribution and termination of nerves in the knee joint of the cat , 1944 .

[19]  E. Dabezies,et al.  Mechanoreceptors in the human anterior cruciate ligament , 1986, The Anatomical record.

[20]  Z. Halata,et al.  Ultrastructure of sensory nerve endings in monkey (Macaca fascicularis) knee joint capsule , 1984, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[21]  Z. Halata,et al.  The ultrastructure of the sensory nerve endings in the articular capsule of the knee joint of the domestic cat (Ruffini corpuscles and Pacinian corpuscles). , 1977, Journal of anatomy.