Quercetin inhibits glucose transport by binding to an exofacial site on GLUT1.

[1]  Xiaozhuo Chen,et al.  Plant‐derived glucose transport inhibitors with potential antitumor activity , 2019, Phytotherapy research : PTR.

[2]  H. Waldmann,et al.  Small‐Molecule Inhibition of Glucose Transporters GLUT‐1–4 , 2019, Chembiochem : a European journal of chemical biology.

[3]  X. Fang,et al.  Ovarian Cancer Relies on Glucose Transporter 1 to Fuel Glycolysis and Growth: Anti-Tumor Activity of BAY-876 , 2018, Cancers.

[4]  Min Young Kim,et al.  Quercetin induces cell death in cervical cancer by reducing O-GlcNAcylation of adenosine monophosphate-activated protein kinase , 2018, Anatomy & cell biology.

[5]  F. Martel,et al.  Antimetabolic Effects of Polyphenols in Breast Cancer Cells: Focus on Glucose Uptake and Metabolism , 2018, Front. Nutr..

[6]  S. Awasthi,et al.  Oxidative stress and dietary phytochemicals: Role in cancer chemoprevention and treatment. , 2018, Cancer letters.

[7]  A. Godwin,et al.  The Role of Compounds Derived from Natural Supplement as Anticancer Agents in Renal Cell Carcinoma: A Review , 2017, International journal of molecular sciences.

[8]  T. Yi,et al.  The Beneficial Effects of Quercetin, Curcumin, and Resveratrol in Obesity , 2017, Oxidative medicine and cellular longevity.

[9]  R. Rahimi,et al.  A Comprehensive Review on Pharmacotherapeutics of Three Phytochemicals, Curcumin, Quercetin, and Allicin, in the Treatment of Gastric Cancer , 2017, Journal of Gastrointestinal Cancer.

[10]  G. Williamson,et al.  The role of polyphenols in modern nutrition , 2017, Nutrition bulletin.

[11]  T. Bernardi,et al.  Research Progress in the Modification of Quercetin Leading to Anticancer Agents , 2017, Molecules.

[12]  Jeremy Wodarek,et al.  Caffeine inhibition of GLUT1 is dependent on the activation state of the transporter. , 2017, Biochimie.

[13]  E. Şengül,et al.  Therapeutic effect of quercetin on renal function and tissue damage in the obesity induced rats. , 2017, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[14]  Binbin Xie,et al.  Glucose transporter GLUT1 expression and clinical outcome in solid tumors: a systematic review and meta-analysis , 2017, Oncotarget.

[15]  P. Haddad,et al.  The Antidiabetic Potential of Quercetin: Underlying Mechanisms. , 2017, Current medicinal chemistry.

[16]  R. Naftalin Faculty Opinions recommendation of Identification and Optimization of the First Highly Selective GLUT1 Inhibitor BAY-876. , 2017 .

[17]  A. Carruthers,et al.  WZB117 (2-Fluoro-6-(m-hydroxybenzoyloxy) Phenyl m-Hydroxybenzoate) Inhibits GLUT1-mediated Sugar Transport by Binding Reversibly at the Exofacial Sugar Binding Site* , 2016, The Journal of Biological Chemistry.

[18]  K. Griffiths,et al.  Food Antioxidants and Their Anti-Inflammatory Properties: A Potential Role in Cardiovascular Diseases and Cancer Prevention , 2016, Diseases.

[19]  Subramani Parasuraman,et al.  Overviews of Biological Importance of Quercetin: A Bioactive Flavonoid , 2016, Pharmacognosy reviews.

[20]  Kathryn E. Hamilton,et al.  Curcumin directly inhibits the transport activity of GLUT1. , 2016, Biochimie.

[21]  R. Ghiasvand,et al.  Quercetin and ovarian cancer: An evaluation based on a systematic review , 2016, Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences.

[22]  Eugenia G. Giannopoulou,et al.  Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH , 2015, Science.

[23]  Jay M. Sage,et al.  Caffeine inhibits glucose transport by binding at the GLUT1 nucleotide-binding site. , 2015, American journal of physiology. Cell physiology.

[24]  A. Green,et al.  Curcumin is a direct inhibitor of glucose transport in adipocytes. , 2014, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[25]  L. Szablewski Expression of glucose transporters in cancers. , 2013, Biochimica et biophysica acta.

[26]  J. Vera,et al.  Noncompetitive blocking of human GLUT1 hexose transporter by methylxanthines reveals an exofacial regulatory binding site. , 2012, American journal of physiology. Cell physiology.

[27]  Shiyong Wu,et al.  A Small-Molecule Inhibitor of Glucose Transporter 1 Downregulates Glycolysis, Induces Cell-Cycle Arrest, and Inhibits Cancer Cell Growth In Vitro and In Vivo , 2012, Molecular Cancer Therapeutics.

[28]  K. Akagawa,et al.  Syntaxin 1C, a soluble form of syntaxin, attenuates membrane recycling by destabilizing microtubules , 2012, Journal of Cell Science.

[29]  M. V. Vander Heiden,et al.  Aerobic glycolysis: meeting the metabolic requirements of cell proliferation. , 2011, Annual review of cell and developmental biology.

[30]  J. Vera,et al.  Hexose transporter GLUT1 harbors several distinct regulatory binding sites for flavones and tyrphostins. , 2011, Biochemistry.

[31]  R. Naftalin,et al.  Quercetin-iron chelates are transported via glucose transporters. , 2011, Free radical biology & medicine.

[32]  Kounosuke Watabe,et al.  Metabolic genes in cancer: their roles in tumor progression and clinical implications. , 2010, Biochimica et biophysica acta.

[33]  S. Devaskar,et al.  Will the original glucose transporter isoform please stand up! , 2009, American journal of physiology. Endocrinology and metabolism.

[34]  K. Kinzler,et al.  Glucose Deprivation Contributes to the Development of KRAS Pathway Mutations in Tumor Cells , 2009, Science.

[35]  Richard J. Naftalin,et al.  Docking Studies Show That D-Glucose and Quercetin Slide through the Transporter GLUT1* , 2006, Journal of Biological Chemistry.

[36]  Tomás Perez-Acle,et al.  Myricetin, quercetin and catechin-gallate inhibit glucose uptake in isolated rat adipocytes. , 2005, The Biochemical journal.

[37]  J. Best,et al.  Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer , 2005, Journal of cellular physiology.

[38]  J. Tamargo,et al.  Nitric oxide (NO) scavenging and NO protecting effects of quercetin and their biological significance in vascular smooth muscle. , 2004, Molecular pharmacology.

[39]  G. F. Fuhrmann,et al.  The inhibitory effects of flavonoids and antiestrogens on the Glut1 glucose transporter in human erythrocytes. , 2003, Chemico-biological interactions.

[40]  W. Pardridge,et al.  Glucose deprivation and hypoxia increase the expression of the GLUT1 glucose transporter via a specific mRNA cis‐acting regulatory element , 2002, Journal of neurochemistry.

[41]  E. van Nood,et al.  Flavonoids: a review of probable mechanisms of action and potential applications. , 2001, The American journal of clinical nutrition.

[42]  J. Vera,et al.  Direct inhibition of the hexose transporter GLUT1 by tyrosine kinase inhibitors. , 2001, Biochemistry.

[43]  M. Levine,et al.  Intracellular accumulation of ascorbic acid is inhibited by flavonoids via blocking of dehydroascorbic acid and ascorbic acid uptakes in HL-60, U937 and Jurkat cells. , 2000, The Journal of nutrition.

[44]  S. Kong,et al.  Inhibition of glucose uptake and suppression of glucose transporter 1 mRNA expression in L929 cells by tumour necrosis factor-alpha. , 1999, Life sciences.

[45]  J. B. Park,et al.  Flavonoids are potential inhibitors of glucose uptake in U937 cells. , 1999, Biochemical and biophysical research communications.

[46]  M. Williams,et al.  Effect of glucose deprivation of GLUT 1 expression in 3T3-L1 adipocytes. , 1993, The Journal of biological chemistry.

[47]  A. Carruthers,et al.  Inhibitions of sugar transport produced by ligands binding at opposite sides of the membrane. Evidence for simultaneous occupation of the carrier by maltose and cytochalasin B. , 1991, Biochemistry.

[48]  Y. Ben-Neriah,et al.  The ubiquitous glucose transporter GLUT-1 belongs to the glucose-regulated protein family of stress-inducible proteins. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[49]  R. M. Krupka,et al.  Cytochalasin B and the kinetics of inhibition of biological transport: a case of asymmetric binding to the glucose carrier. , 1978, Biochimica et biophysica acta.

[50]  D. Basketter,et al.  Asymmetry of the hexose transfer system in human erythrocytes. Comparison of the effects of cytochalasin B, phloretin and maltose as competitive inhibitors. , 1978, The Journal of physiology.

[51]  G. F. Baker,et al.  Asymmetry of the hexose transfer system in human erythrocytes. Experiments with non‐transportable inhibitors. , 1978, The Journal of physiology.

[52]  G. Holman,et al.  Evidence for two asymmetric conformational states in the human erythrocyte sugar-transport system. , 1975, The Biochemical journal.