The Alzheimer’s Disease-Associated Presenilins Are Differentially Phosphorylated Proteins Located Predominantly within the Endoplasmic Reticulum

[1]  C. van Broeckhoven,et al.  The presenilin genes: a new gene family involved in Alzheimer disease pathology. , 1996, Human molecular genetics.

[2]  C. Haass Presenile because of presenilin: the presenilin genes and early onset Alzheimer's disease , 1996, Current opinion in neurology.

[3]  M. Adams,et al.  Complete analysis of the presenilin 1 gene in early onset Alzheimer's disease , 1996, Neuroreport.

[4]  Y. Sakaki,et al.  Regional and cellular presenilin 1 gene expression in human and rat tissues. , 1996, Biochemical and biophysical research communications.

[5]  B. Hyman,et al.  Alzheimer–associated presenilins 1 and 2 : Neuronal expression in brain and localization to intracellular membranes in mammalian cells , 1996, Nature Medicine.

[6]  J. Gilbert,et al.  Mutation analysis of presenilin 1 gene in Alzheimer's disease , 1996, The Lancet.

[7]  Brian J Cummings,et al.  Image analysis of β-amyloid load in Alzheimer's disease and relation to dementia severity , 1995, The Lancet.

[8]  M. Adams,et al.  A mutation in Alzheimer's disease destroying a splice acceptor site in the presenilin-1 gene , 1995, Neuroreport.

[9]  G. Thomas,et al.  Intracellular trafficking of furin is modulated by the phosphorylation state of a casein kinase II site in its cytoplasmic tail. , 1995, The EMBO journal.

[10]  B. Dubois,et al.  Mutations of the presenilin I gene in families with early-onset Alzheimer's disease. , 1995, Human molecular genetics.

[11]  M. Cruts,et al.  Molecular genetic analysis of familial early-onset Alzheimer's disease linked to chromosome 14q24.3. , 1995, Human molecular genetics.

[12]  T. L. Furminger,et al.  Breakpoint characterization of the ret/PTC oncogene in human papillary thyroid carcinoma. , 1995, Human molecular genetics.

[13]  D. Selkoe,et al.  The Swedish mutation causes early-onset Alzheimer's disease by β-secretase cleavage within the secretory pathway , 1995, Nature Medicine.

[14]  Iva Greenwald,et al.  Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene , 1995, Nature.

[15]  J. Growdon,et al.  Familial Alzheimer's chromosome 14 mutations , 1995, Nature Medicine.

[16]  J. Rommens,et al.  Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene , 1995, Nature.

[17]  E M Wijsman,et al.  A familial Alzheimer's disease locus on chromosome 1 , 1995, Science.

[18]  G. Schellenberg,et al.  Candidate gene for the chromosome 1 familial Alzheimer's disease locus , 1995, Science.

[19]  D. Price,et al.  Amyloid beta amyloidosis in Alzheimer's disease. , 1995, Current opinion in neurology.

[20]  D. Pollen,et al.  Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease , 1995, Nature.

[21]  A D Roses,et al.  Apolipoprotein E and Alzheimer disease. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[22]  M. Adams,et al.  The structure of the presenilin 1 (S182) gene and identification of six novel mutations in early onset AD families , 1995, Nature Genetics.

[23]  S. Squazzo,et al.  Evidence that production and release of amyloid beta-protein involves the endocytic pathway. , 1994, The Journal of biological chemistry.

[24]  D. Selkoe,et al.  Mutations associated with a locus for familial Alzheimer's disease result in alternative processing of amyloid beta-protein precursor. , 1994, The Journal of biological chemistry.

[25]  Richard L. Huganir,et al.  Glutamate receptor phosphorylation and synaptic plasticity , 1994, Current Opinion in Neurobiology.

[26]  S. Younkin,et al.  An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants. , 1994, Science.

[27]  D. Y. Thomas,et al.  Calnexin: a membrane-bound chaperone of the endoplasmic reticulum. , 1994, Trends in biochemical sciences.

[28]  A. Robitzki,et al.  Recombinant human casein kinase II , 1994 .

[29]  D. Selkoe,et al.  Normal and abnormal biology of the beta-amyloid precursor protein. , 1994, Annual review of neuroscience.

[30]  A. Robitzki,et al.  Recombinant human casein kinase II. A study with the complete set of subunits (alpha, alpha' and beta), site-directed autophosphorylation mutants and a bicistronically expressed holoenzyme. , 1994, European journal of biochemistry.

[31]  D. Selkoe,et al.  Cellular processing of β-amyloid precursor protein and the genesis of amyloid β-peptide , 1993, Cell.

[32]  J. Growdon,et al.  Activation of protein kinase C inhibits cellular production of the amyloid beta-protein. , 1993, The Journal of biological chemistry.

[33]  M. Mullan,et al.  Genetics and molecular advances in Alzheimer's disease , 1993, Trends in Neurosciences.

[34]  P. Greengard,et al.  Protein phosphorylation inhibits production of Alzheimer amyloid beta/A4 peptide. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[35]  R. Pepperkok,et al.  Cell biological studies with monoclonal and polyclonal antibodies against human casein kinase II subunit beta demonstrate participation of the kinase in mitogenic signaling. , 1993, The Journal of biological chemistry.

[36]  S. Younkin,et al.  Release of excess amyloid beta protein from a mutant amyloid beta protein precursor. , 1993, Science.

[37]  F. Crawford,et al.  Genetic and molecular advances in Alzheimer's disease. , 1993, Trends in neurosciences.

[38]  D. Selkoe,et al.  Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide. , 1993, Cell.

[39]  O. Issinger,et al.  Casein kinases: pleiotropic mediators of cellular regulation. , 1993, Pharmacology & therapeutics.

[40]  D. Selkoe,et al.  Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production , 1992, Nature.

[41]  C. Broeckhoven,et al.  Mapping of a gene predisposing to early–onset Alzheimer's disease to chromosome 14q24.3 , 1992, Nature Genetics.

[42]  D. Pollen,et al.  Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14 , 1992, Nature Genetics.

[43]  J. Weber,et al.  Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14. , 1992, Science.

[44]  J. Growdon,et al.  Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors. , 1992, Science.

[45]  S. L'Hernault,et al.  Mutation of a putative sperm membrane protein in Caenorhabditis elegans prevents sperm differentiation but not its associated meiotic divisions , 1992, The Journal of cell biology.

[46]  D. Selkoe,et al.  Cellular processing of β-amyloid precursor protein and the genesis of amyloid β-peptide , 1993, Cell.

[47]  D. Selkoe,et al.  Homology of the amyloid beta protein precursor in monkey and human supports a primate model for beta amyloidosis in Alzheimer's disease. , 1991, The American journal of pathology.

[48]  M. Pericak-Vance,et al.  Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease , 1991, Nature.

[49]  T. Hunter,et al.  Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates. , 1991, Methods in enzymology.

[50]  P. Greengard,et al.  Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[51]  Andreas Weidemann,et al.  Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein , 1989, Cell.

[52]  K. Grzeschik,et al.  The precursor of Alzheimer??s disease amyloid A4 protein resembles a cell-surface receptor , 1987 .

[53]  W. Huttner Protein tyrosine sulfation , 1987 .

[54]  P. Vassalli,et al.  Lectin-binding sites as markers of Golgi subcompartments: proximal-to- distal maturation of oligosaccharides , 1983, The Journal of cell biology.

[55]  G K Gilbert,et al.  THE ORIGIN OF HYPOTHESES, ILLUSTRATED BY THE DISCUSSION OF A TOPOGRAPHIC PROBLEM. , 1896, Science.