A regulatory motif in nonmuscle myosin II-B regulates its role in migratory front–back polarity

A group of phosphorylatable serine residues within the nonhelical domain of NMII-B controls the ability of NMII-B to generate stable migratory front–rear polarity.

[1]  叶明亮 An Enzyme Assisted RP-RPLC Approach for Phosphoproteome Analysis , 2014 .

[2]  M. Peng,et al.  Toward a comprehensive characterization of a human cancer cell phosphoproteome. , 2013, Journal of proteome research.

[3]  Alan Hall,et al.  Rho family GTPases. , 2012, Biochemical Society transactions.

[4]  D. Discher,et al.  Crawling from soft to stiff matrix polarizes the cytoskeleton and phosphoregulates myosin-II heavy chain , 2012, The Journal of cell biology.

[5]  Miguel Vicente-Manzanares,et al.  Myosin IIA/IIB restrict adhesive and protrusive signaling to generate front–back polarity in migrating cells , 2011, The Journal of cell biology.

[6]  S. Brunak,et al.  Quantitative Phosphoproteomics Reveals Widespread Full Phosphorylation Site Occupancy During Mitosis , 2010, Science Signaling.

[7]  A. Means,et al.  The C-terminal tail region of nonmuscle myosin II directs isoform-specific distribution in migrating cells. , 2008, Molecular biology of the cell.

[8]  Miguel Vicente-Manzanares,et al.  Segregation and activation of myosin IIB creates a rear in migrating cells , 2008, The Journal of cell biology.

[9]  L. Lim,et al.  A Tripartite Complex Containing MRCK Modulates Lamellar Actomyosin Retrograde Flow , 2008, Cell.

[10]  C. Figdor,et al.  The α‐kinases TRPM6 and TRPM7, but not eEF‐2 kinase, phosphorylate the assembly domain of myosin IIA, IIB and IIC , 2008, FEBS letters.

[11]  Miguel Vicente-Manzanares,et al.  Actin and α-actinin orchestrate the assembly and maturation of nascent adhesions in a myosin II motor-independent manner , 2008, Nature Cell Biology.

[12]  Miguel Vicente-Manzanares,et al.  Regulation of protrusion, adhesion dynamics, and polarity by myosins IIA and IIB in migrating cells , 2007, The Journal of cell biology.

[13]  Kenneth M. Yamada,et al.  Myosin IIA regulates cell motility and actomyosin–microtubule crosstalk , 2007, Nature Cell Biology.

[14]  Jake M. Hofman,et al.  Nonmuscle myosin IIA-dependent force inhibits cell spreading and drives F-actin flow. , 2006, Biophysical journal.

[15]  G. Gorodeski,et al.  Estrogen regulates epithelial cell deformability by modulation of cortical actomyosin through phosphorylation of nonmuscle myosin heavy-chain II-B filaments. , 2006, Endocrinology.

[16]  Liron Even-Faitelson,et al.  PAK1 and aPKCzeta regulate myosin II-B phosphorylation: a novel signaling pathway regulating filament assembly. , 2006, Molecular biology of the cell.

[17]  S. Ravid,et al.  Protein kinase Cgamma regulates myosin IIB phosphorylation, cellular localization, and filament assembly. , 2005, Molecular biology of the cell.

[18]  Liron Even-Faitelson,et al.  PAK1 regulates myosin II-B phosphorylation, filament assembly, localization and cell chemotaxis. , 2005, Cellular signalling.

[19]  G. Gundersen,et al.  Nuclear Movement Regulated by Cdc42, MRCK, Myosin, and Actin Flow Establishes MTOC Polarization in Migrating Cells , 2005, Cell.

[20]  Chun-Min Lo,et al.  Nonmuscle myosin IIb is involved in the guidance of fibroblast migration. , 2003, Molecular biology of the cell.

[21]  J. Kolega Asymmetric distribution of myosin IIB in migrating endothelial cells is regulated by a rho-dependent kinase and contributes to tail retraction. , 2003, Molecular biology of the cell.

[22]  J. Shabanowitz,et al.  Phosphoproteome analysis by mass spectrometry and its application to Saccharomyces cerevisiae , 2002, Nature Biotechnology.

[23]  A. Hall,et al.  Integrin-Mediated Activation of Cdc42 Controls Cell Polarity in Migrating Astrocytes through PKCζ , 2001, Cell.

[24]  A. Newton,et al.  Regulation of protein kinase C ζ by PI 3-kinase and PDK-1 , 1998, Current Biology.

[25]  T. Pollard,et al.  Differential localization of myosin-II isozymes in human cultured cells and blood cells. , 1994, Journal of cell science.