Concurrent Thin Basement Membrane Disease and Minimal Change Disease: A Case Report

Thin basement membrane disease is defined as diffuse thinning of the glomerular basement membrane, and is clinically characterized by persistent hematuria, minimal proteinuria, normal renal function, and a benign course. It can occur together with other glomerular diseases. We experienced a case of thin basement membrane disease concurrent with minimal-change disease. Treatment with corticosteroid resulted in improved proteinuria and peripheral edema during the follow-up period. (Korean J Med 2011;80:469-472)

[1]  V. D’Agati,et al.  Adult minimal-change disease: clinical characteristics, treatment, and outcomes. , 2007, Clinical journal of the American Society of Nephrology : CJASN.

[2]  F. Cosio,et al.  Thin basement membrane nephropathy associated with other glomerular diseases. , 2005, Seminars in nephrology.

[3]  Y. Sue,et al.  Clinical features of thin basement membrane disease and associated glomerulopathies , 2004, Nephrology.

[4]  L. Monnens.  Thin glomerular basement membrane disease. , 2001, Kidney international.

[5]  I. Naito,et al.  Diffuse thin glomerular basement membrane in association with idiopathic membranous glomerulonephritis. , 1998, Clinical nephrology.

[6]  F. Cosio,et al.  Association of thin glomerular basement membrane with other glomerulopathies. , 1994, Kidney international.

[7]  K. Sharma,et al.  High glucose-induced proliferation in mesangial cells is reversed by autocrine TGF-β , 1992 .

[8]  K. Sharma,et al.  High glucose-induced proliferation in mesangial cells is reversed by autocrine TGF-beta. , 1992, Kidney international.

[9]  M. Coleman,et al.  Glomerular basement membrane thinning is acquired in minimal change disease. , 1991, American journal of nephrology.

[10]  A. Woodroffe,et al.  Thin membrane nephropathy: a clinico-pathological study. , 1989, Clinical nephrology.

[11]  P. Frederik,et al.  Thin-basement-membrane nephropathy in adults with persistent hematuria. , 1989, The New England journal of medicine.

[12]  K. Konishi,et al.  Thin basement membrane syndrome in adults. , 1987, Journal of clinical pathology.

[13]  H. Shigematsu,et al.  Ultrastructural glomerular loop abnormalities in IgA nephritis. , 1982, Nephron.

[14]  M. White,et al.  Familial benign essential hematuria. , 1973, Archives of internal medicine.