Nanomaterials for Its Use in Biomedicine: An Overview

The rapid incorporation of nanostructures in regenerative medicine can be considered one of the biggest leaps in the production of novel materials for repair and regeneration of damaged tissues. However, despite a large number of articles published, clinical use of these materials is still in its infancy. The complexity and interdisciplinary nature of research aimed to repair damaged tissue and failing organs are the main limiting factors that have halted the progression for developing novel structures for tissue repair. In the present chapter, we revise fundamental concepts to be considered when designing technologies that will have to undergo scrutiny by regulatory agencies prior to being used in humans.

[1]  A. Bangham,et al.  Diffusion of univalent ions across the lamellae of swollen phospholipids. , 1965, Journal of molecular biology.

[2]  Alex Faulkner,et al.  Law’s performativities: Shaping the emergence of regenerative medicine through European Union legislation , 2012, Social studies of science.

[3]  Abdallah S. Daar,et al.  Regenerative medicine: New opportunities for developing countries , 2006 .

[4]  W. D. de Jong,et al.  Drug delivery and nanoparticles: Applications and hazards , 2008, International journal of nanomedicine.

[5]  Meen Chul Kim,et al.  Emerging trends and new developments in regenerative medicine: a scientometric update (2000 – 2014) , 2014, Expert opinion on biological therapy.

[6]  Mritunjai Singh,et al.  NANOTECHNOLOGY IN MEDICINE AND ANTIBACTERIAL EFFECT OF SILVER NANOPARTICLES , 2008 .

[7]  Yiannis Ventikos,et al.  On the genealogy of tissue engineering and regenerative medicine. , 2015, Tissue engineering. Part B, Reviews.

[8]  O. Olatunji Biomedical Application of Natural Polymers , 2016 .

[9]  Bo Kara,et al.  The translation of cell-based therapies: clinical landscape and manufacturing challenges. , 2015, Regenerative medicine.

[10]  Paul Kemp,et al.  History of regenerative medicine: looking backwards to move forwards. , 2006, Regenerative medicine.

[11]  Ana Jaklenec,et al.  Great expectations: private sector activity in tissue engineering, regenerative medicine, and stem cell therapeutics. , 2008, Tissue engineering. Part A.

[12]  H. Goesmann,et al.  Nanoparticulate functional materials. , 2010, Angewandte Chemie.

[13]  J. James,et al.  Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intratracheal instillation. , 2003, Toxicological sciences : an official journal of the Society of Toxicology.

[14]  M. G. Krukemeyer,et al.  History and Possible Uses of Nanomedicine Based on Nanoparticles and Nanotechnological Progress , 2015 .

[15]  K. Kimura,et al.  Japan's challenges of translational regenerative medicine: Act on the safety of regenerative medicine , 2016, Regenerative therapy.

[16]  Ashok Kumar,et al.  Biomaterials and bioengineering tomorrow’s healthcare , 2013, Biomatter.

[17]  Volker Wagner,et al.  The emerging nanomedicine landscape , 2006, Nature Biotechnology.

[18]  JG Allickson Emerging Translation of Regenerative Therapies , 2017, Clinical pharmacology and therapeutics.

[19]  Bharat Bhushan Introduction to Nanotechnology , 2010 .

[20]  C. Mason,et al.  A brief definition of regenerative medicine. , 2008, Regenerative medicine.

[21]  A. Caplan,et al.  Progressive Approval: A Proposal for a New Regulatory Pathway for Regenerative Medicine , 2014, Stem cells translational medicine.

[22]  Binil Starly,et al.  Manufacturing Road Map for Tissue Engineering and Regenerative Medicine Technologies , 2015, Stem cells translational medicine.

[23]  E. Lissi,et al.  Association models for binding of molecules to nanostructures. , 2017, The Analyst.

[24]  E. Suuronen,et al.  Sprayable peptide-modified silver nanoparticles as a barrier against bacterial colonization. , 2016, Nanoscale.

[25]  F. Marincola The trouble with translational medicine , 2011, Journal of internal medicine.

[26]  Kevin G. Stamplecoskie,et al.  Silver Nanoparticles: From Bulk Material to Colloidal Nanoparticles , 2015 .

[27]  Manfred F. Maitz,et al.  Applications of synthetic polymers in clinical medicine , 2015 .

[28]  S. Kumbar,et al.  Natural Polymers: Polysaccharides and Their Derivatives for Biomedical Applications , 2014 .

[29]  H. Atkins,et al.  The global landscape of stem cell clinical trials. , 2014, Regenerative medicine.

[30]  Ventola Cl,et al.  The nanomedicine revolution: part 1: emerging concepts. , 2012, P & T : a peer-reviewed journal for formulary management.

[31]  François Berthiaume,et al.  Tissue Engineering and Regenerative Medicine : History , Progress , and Challenges , 2013 .

[32]  Mehdi Kamali,et al.  Recent biomedical applications of gold nanoparticles: A review. , 2018, Talanta.

[33]  Sumit Kumar Singh,et al.  Protein Nanoparticles: Promising Platforms for Drug Delivery Applications. , 2018, ACS biomaterials science & engineering.

[34]  C. Mason,et al.  The global cell therapy industry continues to rise during the second and third quarters of 2012. , 2012, Cell stem cell.

[35]  Feng Chen,et al.  Synthesis and biomedical applications of copper sulfide nanoparticles: from sensors to theranostics. , 2014, Small.

[36]  K. Dreher,et al.  Health and environmental impact of nanotechnology: toxicological assessment of manufactured nanoparticles. , 2003, Toxicological sciences : an official journal of the Society of Toxicology.

[37]  Felix Kratz,et al.  Albumin as a drug carrier: design of prodrugs, drug conjugates and nanoparticles. , 2008, Journal of controlled release : official journal of the Controlled Release Society.

[38]  Alexandru Mihai Grumezescu,et al.  Biomedical Applications of Silver Nanoparticles: An Up-to-Date Overview , 2018, Nanomaterials.

[39]  Peter X Ma,et al.  Nanostructured Biomaterials for Regeneration , 2008, Advanced functional materials.

[40]  Carlijn V C Bouten,et al.  Then and now: hypes and hopes of regenerative medicine. , 2013, Trends in biotechnology.

[41]  J. Hyllner,et al.  Cell-based therapy technology classifications and translational challenges , 2015, Philosophical Transactions of the Royal Society B: Biological Sciences.

[42]  Mark A Sussman,et al.  Enhancement Strategies for Cardiac Regenerative Cell Therapy: Focus on Adult Stem Cells. , 2018, Circulation research.

[43]  Michael J Lysaght,et al.  Tissue engineering: the end of the beginning. , 2004, Tissue engineering.

[44]  Xueya Wang,et al.  Intelligent nanomaterials for medicine: carrier platforms and targeting strategies in the context of clinical application. , 2013, Nanomedicine : nanotechnology, biology, and medicine.

[45]  A. Forgione,et al.  Regenerative medicine: Historical roots and potential strategies in modern medicine , 2015, Journal of microscopy and ultrastructure.

[46]  Y. Duan,et al.  Chemistry, biology, and medicine of fluorescent nanomaterials and related systems: new insights into biosensing, bioimaging, genomics, diagnostics, and therapy. , 2014, Chemical reviews.

[47]  E. Suuronen,et al.  Biomolecule Silver Nanoparticle-Based Materials for Biomedical Applications , 2019, Handbook of Ecomaterials.

[48]  G. Gores,et al.  Regenerative Medicine Build-Out , 2015, Stem cells translational medicine.

[49]  H. Yang,et al.  Recent progress in biomedical applications of titanium dioxide. , 2013, Physical chemistry chemical physics : PCCP.