Development of the Home Pregnancy Test

Abstract: The home pregnancy testworks by measuring human chorionic gonadotropin (hCG) hormone in urine. This hormone was initially studied in NICHD intramural laboratories as a reliable marker of certain tumors. Refinement of the assay for hCG detection to enhance specificity enabled its ready application to pregnancy detection.

[1]  G. Ross,et al.  Specific radioimmunoassay of chorionic gonadotropin during implantation in rhesus monkeys. , 1974, The Journal of clinical endocrinology and metabolism.

[2]  G T Ross,et al.  A radioimmunoassay which specifically measures human chorionic gonadotropin in the presence of human luteinizing hormone. , 1972, American journal of obstetrics and gynecology.

[3]  J. Vaitukaitis.  Changing placental concentrations of human chorionic gonadotropin and its subunits during gestation. , 1974, The Journal of clinical endocrinology and metabolism.

[4]  R. Goldenberg,et al.  Hormonal factors influencing ovarian uptake of human chorionic gonadotropin. , 1973, Endocrinology.

[5]  J. Pierce,et al.  Generation of specific antisera with the hormone-specific beta-subunit of hTSH or hFSH. , 1973, The Journal of clinical endocrinology and metabolism.

[6]  R. Canfield,et al.  Use of specific antisera to characterize biologic activity of hCG-beta subunit preparations. , 1972, Endocrinology.

[7]  J. Vaitukaitis.  Human chorionic gonadotropin as a tumor marker. , 1974, Annals of clinical and laboratory science.

[8]  G. Braunstein,et al.  The in vivo behavior of human chorionic gonadotropin after dissociation into subunits. , 1972, Endocrinology.

[9]  K. Catt,et al.  Appearance of hCG in pregnancy plasma following the initiation of implantation of the blastocyst. , 1975, The Journal of clinical endocrinology and metabolism.

[10]  G. Ross,et al.  Recent advances in evaluation of gonadotropic hormones. , 1973, Annual review of medicine.

[11]  R. Vigersky,et al.  Delayed pituitary hormone response to LRF and TRF in patients with anorexia nervosa and with secondary amenorrhea associated with simple weight loss. , 1976, The Journal of clinical endocrinology and metabolism.

[12]  J. Vaitukaitis,et al.  Role of cyclic nucleotides in modulating ovarian hCG action. , 1977, Endocrine research communications.

[13]  J. Vaitukaitis.  Editorial: When is a tumor marker not a tumor marker? , 1975, The New England journal of medicine.

[14]  R. Canfield,et al.  Properties of the subunits of human chorionic gonadotropin. , 1974, Endocrinology.

[15]  G. Ross,et al.  Neutralization of primate chorionic gonadotropin activities by antisera against the subunits of human chorionic gonadotropin in radioimmunoassay and bioassay. , 1973, Endocrinology.

[16]  J. Vaitukaitis,et al.  Evidence for altered synthesis of human chorionic gonadotropin in gestational trophoblastic tumors. , 1976, The Journal of clinical endocrinology and metabolism.

[17]  G. Braunstein,et al.  Gonadotropins and their subunits: basic and clinical studies. , 1976, Recent progress in hormone research.

[18]  J. Vaitukaitis.  Immunologic and physical characterization of human chorionic gonadotropin (hCG) secreted by tumors. , 1973, The Journal of clinical endocrinology and metabolism.

[19]  G. Braunstein,et al.  Ectopic production of human chorionic gonadotrophin by neoplasms. , 1973, Annals of internal medicine.