Improved synthesis of the bifunctional chelating agent 1,4,7,10-tetraaza-N-(1-carboxy-3-(4-nitrophenyl)propyl)-N',N'',N'''-tri s(acetic acid)cyclododecane (PA-DOTA).

[1]  L. Chappell,et al.  Effect of Mixed Pendent Groups on the Solution and Catalytic Properties of Europium(III) Macrocyclic Complexes: Bifunctional and Monofunctional Amide and Alcohol Pendents in Septadentate or Octadentate Ligands. , 1998, Inorganic chemistry.

[2]  J. Stimmel,et al.  Samarium-153 and lutetium-177 chelation properties of selected macrocyclic and acyclic ligands. , 1998, Nuclear medicine and biology.

[3]  T. Odom-Maryon,et al.  Biodistribution of 111In- and 90Y-labeled DOTA and maleimidocysteineamido-DOTA conjugated to chimeric anticarcinoembryonic antigen antibody in xenograft-bearing nude mice: comparison of stable and chemically labile linker systems. , 1998, Bioconjugate chemistry.

[4]  P. Hand,et al.  A CDR-grafted (humanized) domain-deleted antitumor antibody. , 1997, Cancer biotherapy & radiopharmaceuticals.

[5]  M. Tweedle,et al.  Synthesis, Stability, and Crystal Structure Studies of Some Ca2+, Cu2+, and Zn2+ Complexes of Macrocyclic Polyamino Carboxylates , 1995 .

[6]  G. Curt,et al.  Phase I study of intravenous Lu-labeled CC49 murine monoclonal antibody in patients with advanced adenocarcinoma. , 1995, Clinical cancer research : an official journal of the American Association for Cancer Research.

[7]  E. Padlan,et al.  Generation, characterization, and in vivo studies of humanized anticarcinoma antibody CC49. , 1995, Hybridoma.

[8]  T. J. Norman,et al.  Improved tumour targeting with recombinant antibody–macrocycle conjugates , 1995 .

[9]  M. Brechbiel,et al.  Biodistribution and metabolism of targeted and nontargeted protein-chelate-gadolinium complexes: evidence for gadolinium dissociation in vitro and in vivo. , 1995, Magnetic resonance imaging.

[10]  I. Lázár,et al.  Kinetics of Formation and Dissociation of Lanthanide(III)-DOTA Complexes , 1994 .

[11]  J. Schlom,et al.  Biodistribution and preclinical radioimmunotherapy studies using radiolanthanide‐labeled immunoconjugates , 1994, Cancer.

[12]  M. Tweedle,et al.  Equilibrium and Kinetic Studies of Lanthanide Complexes of Macrocyclic Polyamino Carboxylates , 1993 .

[13]  C. A. Langhoff,et al.  Unexpected selectivity in the alkylation of polyazamacrocycles , 1993 .

[14]  Xiangyun Wang,et al.  A kinetic investigation of the lanthanide DOTA chelates. Stability and rates of formation and of dissociation of a macrocyclic gadolinium(III) polyaza polycarboxylic MRI contrast agent , 1992 .

[15]  M. Brechbiel,et al.  Convenient synthesis of bifunctional tetraaza macrocycles. , 1992, Bioconjugate chemistry.

[16]  J. Schlom,et al.  Monoclonal antibody-based therapy of a human tumor xenograft with a 177lutetium-labeled immunoconjugate. , 1991, Cancer research.

[17]  M. Brechbiel,et al.  Backbone-substituted DTPA ligands for 90Y radioimmunotherapy. , 1991, Bioconjugate chemistry.

[18]  C.‐C. Wu,et al.  Radiolabeling of monoclonal antibodies with metal chelates , 1991 .

[19]  G. Denardo,et al.  Yttrium-90-labeled monoclonal antibody for therapy: labeling by a new macrocyclic bifunctional chelating agent. , 1990, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[20]  D. Parker.  Tumour targeting with radiolabelled macrocycle–antibody conjugates , 1990 .

[21]  P W Doherty,et al.  Patient biodistribution of intraperitoneally administered yttrium-90-labeled antibody. , 1988, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[22]  S. Denardo,et al.  The peptide way to macrocyclic bifunctional chelating agents: synthesis of 2-(p-nitrobenzyl)-1,4,7,10-tetraazacyclododecane-N,N',N",N'''-tetraacetic acid and study of its yttrium(III) complex. , 1988, Journal of the American Chemical Society.

[23]  R. Lauffer,et al.  Paramagnetic metal complexes as water proton relaxation agents for NMR imaging: theory and design , 1987 .

[24]  D. E. Simpson,et al.  Synthesis of 1-(p-isothiocyanatobenzyl) derivatives of DTPA and EDTA. Antibody labeling and tumor-imaging studies , 1986 .

[25]  M. Loncin,et al.  Coordination of lanthanides by two polyamino polycarboxylic macrocycles: formation of highly stable lanthanide complexes , 1986 .

[26]  P. Bunn,et al.  Determination of the immunoreactive fraction of radiolabeled monoclonal antibodies by linear extrapolation to binding at infinite antigen excess. , 1984, Journal of immunological methods.